Anne P. Beigneux

University of California, Los Angeles — United States

Medicine · Health Sciences

48h-index7.4kcitations111works1.32yr avg
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Research Topics

Lipid metabolism and disorders(75), Diabetes, Cardiovascular Risks, and Lipoproteins(48), Caveolin-1 and cellular processes(37), Diabetes and associated disorders(22), Peroxisome Proliferator-Activated Receptors(13)

Publications111 total

A neutralizing APOA5 monoclonal antibody reduces amounts of lipoprotein lipase in capillaries and triggers hypertriglyceridemia
Proceedings of the National Academy of Sciences·2026Open Access
GPIHBP1, lipoprotein lipase, and triglyceride-rich lipoproteins in capillaries of the choroid plexus and circumventricular organs
Journal of Clinical Investigation·2025· 1 citedOpen Access
Distinct strategies for intravascular triglyceride metabolism in hearts of mammals and lower vertebrate species
JCI Insight·2024· 2 citedOpen Access
Quantification of lipoprotein lipase in mouse plasma with a sandwich enzyme-linked immunosorbent assay
Journal of Lipid Research·2024· 2 citedOpen Access
The lipoprotein lipase that is shuttled into capillaries by GPIHBP1 enters the glycocalyx where it mediates lipoprotein processing
Proceedings of the National Academy of Sciences·2023· 20 citedOpen Access
Hypertriglyceridemia in Apoa5–/– mice results from reduced amounts of lipoprotein lipase in the capillary lumen
Journal of Clinical Investigation·2023· 17 citedOpen Access
Intracapillary LPL levels in brown adipose tissue, visualized with an antibody-based approach, are regulated by ANGPTL4 at thermoneutral temperatures
Proceedings of the National Academy of Sciences·2023· 14 citedOpen Access
A protein of capillary endothelial cells, GPIHBP1, is crucial for plasma triglyceride metabolism
Proceedings of the National Academy of Sciences·2022· 24 citedOpen Access
Agpat6 —a novel lipid biosynthetic gene required for triacylglycerol production in mammary epithelium
UNC Libraries·2020Open Access
Chylomicronemia from GPIHBP1 autoantibodies
Journal of Lipid Research·2020· 45 citedOpen Access
Chylomicronemia From GPIHBP1 Autoantibodies Successfully Treated With Rituximab: A Case Report
Annals of Internal Medicine·2020· 15 citedOpen Access
The structural basis for monoclonal antibody 5D2 binding to the tryptophan-rich loop of lipoprotein lipase
Journal of Lipid Research·2020· 17 citedOpen Access
Intermittent chylomicronemia caused by intermittent GPIHBP1 autoantibodies
Journal of clinical lipidology·2020· 19 citedOpen Access
Detection Of Circulating Gpihbp1-Gpihbp1 Autoantibody Complex In High Tg Plasma Of Patients With A History Of Acute Pancreatitis
Atherosclerosis·2019
GPIHBP1 and Lipoprotein Lipase, Partners in Plasma Triglyceride Metabolism
Cell Metabolism·2019· 132 citedOpen Access
GPIHBP1 expression in gliomas promotes utilization of lipoprotein-derived nutrients
eLife·2019· 18 citedOpen Access
Author response: GPIHBP1 expression in gliomas promotes utilization of lipoprotein-derived nutrients
2019Open Access
Lipoprotein lipase is active as a monomer
Proceedings of the National Academy of Sciences·2019· 77 citedOpen Access
An upstream enhancer regulates Gpihbp1 expression in a tissue-specific manner
Journal of Lipid Research·2018· 7 citedOpen Access
Structure of the lipoprotein lipase–GPIHBP1 complex that mediates plasma triglyceride hydrolysis
Proceedings of the National Academy of Sciences·2018· 91 citedOpen Access
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Frequent Co-authors

Stephen G. Young(46), Loren G. Fong(34), André Bensadoun(20), Brandon S.J. Davies(18), Peter Gin(14), Michael M. Weinstein(12), Michael Ploug(10), Karen Reue(6), Haibo Jiang(5), Peter Tontonoz(5), Christopher M. Allan(5), Arthur H. Moser(4), Carl Grünfeld(4), Kenneth R. Feingold(4), Chris N. Goulbourne(4), Mikael Larsson(4), Constance V. Voss(4), Xin Qiao(3), Rosemary L. Walzem(3), Kristan Melford(3)