Karl G. Helmer

Massachusetts General Hospital — United States

Medicine · Health Sciences

33h-index5.6kcitations108works1.62yr avg
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Research Topics

Advanced Neuroimaging Techniques and Applications(30), Advanced MRI Techniques and Applications(24), Functional Brain Connectivity Studies(16), Cerebrovascular and Carotid Artery Diseases(15), Dementia and Cognitive Impairment Research(13)

Publications108 total

Abstract WP130: MRI-Detected Embolic Infarcts in Atrial Fibrillation Patients without History of Stroke: Prevalence, Characteristics, Predictors, and Potential Sources
Stroke·2026
<scp>MarkVCID2</scp> Consortium for Clinical Validation of Biomarkers of Cerebral Small Vessel Disease: Validation Framework and Baseline Characteristics
Annals of Neurology·2025· 3 cited
Microvascular and Blood–Brain Barrier Dysfunction in COL4A1-Related cSVD Can Be Identified by MR DSC Perfusion Imaging
2025Open Access
Safety and efficacy of leriglitazone in childhood cerebral adrenoleukodystrophy (NEXUS): an interim analysis of an open-label, phase 2/3 trial
EClinicalMedicine·2025· 3 citedOpen Access
Extended Technical and Clinical Validation of Deep Learning‐Based Brainstem Segmentation for Application in Neurodegenerative Diseases
Human Brain Mapping·2025· 2 citedOpen Access
Abstract WP57: The Effects of Atrial Fibrillation Burden on Cognitive Function and Brain Structure
Stroke·2025
Abstract WP47: Atrial Fibrillation Burden and Enlarged Perivascular Spaces in Basal Ganglia
Stroke·2025
Technical and Clinical Validation of a Novel Deep Learning-Based White Matter Hyperintensity Segmentation Tool
SSRN Electronic Journal·2025· 1 citedOpen Access
Technical and clinical validation of a novel deep learning-based white matter hyperintensity segmentation tool
Cerebral Circulation - Cognition and Behavior·2025· 1 citedOpen Access
White matter free water mediates the associations between placental growth factor, white matter hyperintensities, and cognitive status
Alzheimer s & Dementia·2024· 6 citedOpen Access
Cerebrovascular reactivity (CVR) MRI as a biomarker for cerebral small vessel disease (SVD) related cognitive decline: Multi‐site validation in the MarkVCID Consortium
Alzheimer s & Dementia·2024· 1 citedOpen Access
The ARTS Marker of Arteriolosclerosis: Instrumental and Clinical Validation
Alzheimer s & Dementia·2024· 1 citedOpen Access
The ARTS Marker of Arteriolosclerosis: Instrumental and Clinical Validation
Alzheimer s & Dementia·2024Open Access
Instrumental and biological validation of PSMD as a VCID biomarker
Alzheimer s & Dementia·2024Open Access
Cerebrovascular reactivity (CVR) MRI as a biomarker for cerebral small vessel disease (SVD) related cognitive decline: Multi‐site validation in the MarkVCID Consortium
Alzheimer s & Dementia·2024Open Access
White matter free water: a sensitive biomarker of small vascular disease for VCID research
Alzheimer s & Dementia·2024Open Access
Validation of diffusivity along the perivascular space as a biomarker for vascular cognitive impairment and dementia
Alzheimer s & Dementia·2024Open Access
Validation of diffusivity analysis along the perivascular space (ALPS) index as a biomarker for vascular cognitive impairment and dementia
Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition·2024
Cross vendors test-retest validation of diffusion tensor image analysis along the perivascular space for evaluating glymphatic system function
Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition·2024
Cerebrovascular reactivity (CVR) MRI as a biomarker for small vessel disease related cognitive decline: validation in the MarkVCID Consortium
Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition·2024
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Frequent Co-authors

Christopher H. Sotak(18), Steven M. Greenberg(9), Claudia L. Satizábal(9), Kristin Schwab(8), Herpreet Singh(8), Pauline Maillard(7), Sudha Seshadri(7), Hanzhang Lu(7), Martha E. Shenton(6), Ofer Pasternak(6), Inga K. Koerte(6), Jessica A. Turner(6), Brian T. Gold(6), Danny J.J. Wang(6), Sylvain Bouix(5), Charles DeCarli(5), Matthew D. Silva(5), Joel H. Kramer(5), Arvind Caprihan(5), P. Grigg(5)