Christopher R. Gibson

Merck & Co., Inc., Rahway, NJ, USA (United States) — United States

Pharmacology, Toxicology and Pharmaceutics · Life Sciences

22h-index2.4kcitations75works8.82yr avg
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Research Topics

Pharmacogenetics and Drug Metabolism(28), Drug Transport and Resistance Mechanisms(13), Computational Drug Discovery Methods(9), Statistical Methods in Clinical Trials(9), Analytical Chemistry and Chromatography(8)

Publications75 total

Evaluation of cytochrome P450 (CYP) induction using RT‐qPCR in exosomes isolated from plasma samples: Method development and qualification
British Journal of Clinical Pharmacology·2026
Correction to “Large-Scale Compartmental Model-Based Study of Preclinical Pharmacokinetic Data and Its Impact on Compound Triaging in Drug Discovery”
Molecular Pharmaceutics·2026
Guided Sample Pooling in Human Mass Balance Studies: A Recommended Strategic Decision Framework
Clinical Pharmacology & Therapeutics·2025Open Access
Drug Interaction PBPK Modeling: Review of the Literature Exposes the Need for Increased Verification of Model Inputs and Outputs as Part of Credibility Assessment
Clinical and Translational Science·2025· 5 citedOpen Access
Assess CYP450 induction by qRT-PCR quantificaiton of CYP450 mRNAs from Small Extracellular Vesicles (SEVS) derived from plasma
Drug Metabolism and Pharmacokinetics·2025
Large-Scale Compartmental Model-Based Study of Preclinical Pharmacokinetic Data and Its Impact on Compound Triaging in Drug Discovery
Molecular Pharmaceutics·2025· 1 cited
Large scale compartmental model-based study of preclinical pharmacokinetic data and its impact on compound triaging in drug discovery
2024Open Access
GPT-4o System Card
arXiv (Cornell University)·2024· 88 citedOpen Access
THE BRADYKININ CHALLENGE MODEL IN NON-HUMAN PRIMATES SUCCESSFULLY PREDICTED EFFICACIOUS DOSES OF DEUCRICTIBANT IN HUMANS
Annals of Allergy Asthma & Immunology·2024
Large scale compartmental model-based study of preclinical pharmacokinetic data and its impact on compound triaging in drug discovery
2024Open Access
Dealing With Variable Drug Exposure Due to Variable Hepatic Metabolism: A Proof‐of‐Concept Application of Liquid Biopsy in Renal Impairment
Clinical Pharmacology & Therapeutics·2024· 12 citedOpen Access
Method development and optimization for detecting mRNAS of drug metabolizing enzymes and transporters in exosomes derived from human blood
Drug Metabolism and Pharmacokinetics·2024
Physiologically-based modeling of cholate disposition in beagle dog with and without treatment of the liver transporter inhibitor simeprevir
Computational Toxicology·2022· 1 citedOpen Access
Translational Pharmacokinetic–Pharmacodynamic Modeling of NaV1.7 Inhibitor MK-2075 to Inform Human Efficacious Dose
Frontiers in Pharmacology·2021· 7 citedOpen Access
Measurement of total liver blood flow in intact anesthetized rats using ultrasound imaging
Pharmacology Research & Perspectives·2021· 12 citedOpen Access
Variability in Human In Vitro Enzyme Kinetics
Methods in molecular biology·2021· 4 cited
Supporting US public health experts
Nature Biotechnology·2020Open Access
P152 PHA-022121, A SELECTIVE BRADYKININ-B2-RECEPTOR ANTAGONIST, IS SAFE AND SHOWS RAPID ORAL BIOAVAILABILITY IN HUMANS
Annals of Allergy Asthma & Immunology·2020· 2 cited
Application of Pharmacokinetic-Pharmacodynamic Modeling to Inform Translation of In Vitro NaV1.7 Inhibition to In Vivo Pharmacological Response in Non-human Primate
Pharmaceutical Research·2020· 5 citedOpen Access
P213 - A priori prediction of CYP3A victim drug-drug interaction of MK-1 and diltiazem using physiologically-based pharmacokinetic modeling (PBPK): qualification using clinical data
Drug Metabolism and Pharmacokinetics·2020
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Frequent Co-authors

Jeanine Ballard(5), Barbara J. Ring(5), Jenny Y. Chien(5), Kimberly K. Adkison(5), Hannah M. Jones(5), Rhys D.O. Jones(5), James Yates(5), M. Sherry Ku(5), Handan He(5), Ragini Vuppugalla(5), Punit Marathe(5), Volker Fischer(5), Sandeep Dutta(5), Vikash K. Sinha(5), Thorir D. Bjornsson(5), Thierry Lavé(5), Patrick Poulin(5), Weilian Yang(5), Rolf F. Barth(5), Alfred E. Staubus(5)