Albert H. Chan

Leidos (United States) — United States

Medicine · Health Sciences

17h-index854citations50works3.52yr avg
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Research Topics

HIV/AIDS drug development and treatment(12), Cancer, Hypoxia, and Metabolism(10), Nitric Oxide and Endothelin Effects(9), Biochemical and Molecular Research(9), Protein Kinase Regulation and GTPase Signaling(8)

Publications50 total

Abstract A063: BBO-11818: an orally bioavailable, highly potent and selective non-covalent pan-KRAS(ON) and (OFF) inhibitor with robust anti-tumor activity in KRAS-mutant preclinical models
Molecular Cancer Therapeutics·2025
Structural basis for LZTR1 recognition of RAS GTPases for degradation
Science·2025· 5 cited
Biophysical and structural analysis of KRAS switch-II pocket inhibitors reveals allele-specific binding constraints
Journal of Biological Chemistry·2025· 6 citedOpen Access
Blocking C-terminal processing of KRAS4b via a direct covalent attack on the CaaX-box cysteine
Proceedings of the National Academy of Sciences·2025· 3 citedOpen Access
Abstract 3788: BBO-8520, a first-in-class direct dual inhibitor of GTP-bound (ON) and GDP-bound (OFF) KRASG12C, exhibits robust efficacy in non-small cell lung cancer preclinical models
Cancer Research·2025
Abstract 4378: BBO-11818, an orally bioavailable, highly potent and non-covalent pan-KRAS inhibitor demonstrates robust anti-tumor activity in KRAS-mutant preclinical models
Cancer Research·2025· 4 cited
Supplementary Figure S6 from Discovery of BBO-8520, a First-In-Class Direct and Covalent Dual Inhibitor of GTP-Bound (ON) and GDP-Bound (OFF) KRAS<sup>G12C</sup>
2025Open Access
Supplementary Table S2 from Discovery of BBO-8520, a First-In-Class Direct and Covalent Dual Inhibitor of GTP-Bound (ON) and GDP-Bound (OFF) KRAS<sup>G12C</sup>
2025Open Access
Supplementary Figure S2 from Discovery of BBO-8520, a First-In-Class Direct and Covalent Dual Inhibitor of GTP-Bound (ON) and GDP-Bound (OFF) KRAS<sup>G12C</sup>
2025Open Access
Supplementary Figure S3 from Discovery of BBO-8520, a First-In-Class Direct and Covalent Dual Inhibitor of GTP-Bound (ON) and GDP-Bound (OFF) KRAS<sup>G12C</sup>
2025Open Access
Supplementary Table S1 from Discovery of BBO-8520, a First-In-Class Direct and Covalent Dual Inhibitor of GTP-Bound (ON) and GDP-Bound (OFF) KRAS<sup>G12C</sup>
2025Open Access
Supplementary Figure S4 from Discovery of BBO-8520, a First-In-Class Direct and Covalent Dual Inhibitor of GTP-Bound (ON) and GDP-Bound (OFF) KRAS<sup>G12C</sup>
2025Open Access
Supplementary Figure S5 from Discovery of BBO-8520, a First-In-Class Direct and Covalent Dual Inhibitor of GTP-Bound (ON) and GDP-Bound (OFF) KRAS<sup>G12C</sup>
2025Open Access
Supplementary Figure S1 from Discovery of BBO-8520, a First-In-Class Direct and Covalent Dual Inhibitor of GTP-Bound (ON) and GDP-Bound (OFF) KRAS<sup>G12C</sup>
2025Open Access
Supplementary Material and Methods from Discovery of BBO-8520, a First-In-Class Direct and Covalent Dual Inhibitor of GTP-Bound (ON) and GDP-Bound (OFF) KRAS<sup>G12C</sup>
2025Open Access
Data from Discovery of BBO-8520, a First-In-Class Direct and Covalent Dual Inhibitor of GTP-Bound (ON) and GDP-Bound (OFF) KRAS<sup>G12C</sup>
2025Open Access
Discovery of BBO-8520, a First-In-Class Direct and Covalent Dual Inhibitor of GTP-Bound (ON) and GDP-Bound (OFF) KRASG12C
Cancer Discovery·2024· 33 citedOpen Access
Abstract ND07: BBO-8520, a first-in-class, direct inhibitor of KRASG12C (ON), locks GTP-bound KRASG12C in the state 1 conformation resulting in rapid and complete blockade of effector binding
Cancer Research·2024· 10 cited
Crystallographic Studies of KRAS in Complex with Small Molecules and RAS-Binding Proteins
Methods in molecular biology·2024· 6 cited
Exploring novel <scp>HIV</scp>‐1 reverse transcriptase inhibitors with drug‐resistant mutants: A double mutant surprise
Protein Science·2023· 5 citedOpen Access
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Frequent Co-authors

Dhirendra K. Simanshu(29), Dwight V. Nissley(26), Andrew G. Stephen(22), Frank McCormick(20), Felice C. Lightstone(18), Dominic Esposito(17), Dana Rabara(16), Erik K. Larsen(16), Alok K. Sharma(15), Marcin Dyba(15), Saman Setoodeh(15), Patrick Alexander(15), Keshi Wang(15), Kerstin W. Sinkevicius(15), Eli Wallace(15), Pedro J. Beltran(15), John-Paul Denson(14), Anna E. Maciag(14), James P. Stice(14), Bryan D. Smith(14)