George K. Abruzzo

Merck & Co., Inc., Rahway, NJ, USA (United States) — United States

Medicine · Health Sciences

32h-index4.3kcitations71works0.02yr avg
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Research Topics

Antifungal resistance and susceptibility(38), Fungal Infections and Studies(15), Microbial Natural Products and Biosynthesis(10), Fungal Biology and Applications(9), Carbohydrate Chemistry and Synthesis(6)

Publications71 total

Ibrexafungerp: An orally active β-1,3-glucan synthesis inhibitor
Bioorganic & Medicinal Chemistry Letters·2020· 49 cited
MK-5204: An orally active β-1,3-glucan synthesis inhibitor
Bioorganic & Medicinal Chemistry Letters·2020· 6 cited
Preclinical Pharmacokinetics and Pharmacodynamic Target of SCY-078, a First-in-Class Orally Active Antifungal Glucan Synthesis Inhibitor, in Murine Models of Disseminated Candidiasis
Antimicrobial Agents and Chemotherapy·2017· 92 citedOpen Access
Novel orally active inhibitors of β-1,3-glucan synthesis derived from enfumafungin
Bioorganic & Medicinal Chemistry Letters·2015· 33 citedOpen Access
Synthesis and antifungal evaluation of pentyloxyl-diphenylisoxazoloyl pneumocandins and echinocandins
Bioorganic & Medicinal Chemistry Letters·2013· 14 citedOpen Access
Isolation, Structure, and Biological Activity of Phaeofungin, a Cyclic Lipodepsipeptide from a <i>Phaeosphaeria</i> sp. Using the Genome-Wide <i>Candida albicans</i> Fitness Test
Journal of Natural Products·2012· 24 cited
Antifungal Spectrum, In Vivo Efficacy, and Structure–Activity Relationship of Ilicicolin H
ACS Medicinal Chemistry Letters·2012· 62 cited
Structure and biological activity of a cyclic lipodepsipeptide phaeofungin discovered with the Candida albicans fitness test
Planta Medica·2012
Efficacy of Caspofungin in a Juvenile Mouse Model of Central Nervous System Candidiasis
Antimicrobial Agents and Chemotherapy·2011· 20 cited
Isolation, Structure Elucidation, and Biological Activity of Virgineone from <i>Lachnum virgineum</i> Using the Genome-Wide <i>Candida albicans</i> Fitness Test
Journal of Natural Products·2008· 47 cited
Isolation, structure and biological activity of phomafungin, a cyclic lipodepsipeptide from a widespread tropical Phoma sp.
Bioorganic & Medicinal Chemistry·2008· 44 cited
PAP Inhibitor with In Vivo Efficacy Identified by Candida albicans Genetic Profiling of Natural Products
Chemistry & Biology·2008· 82 cited
In Vivo Efficacy of a Novel Oxazolidinone Compound in Two Mouse Models of Infection
Antimicrobial Agents and Chemotherapy·2007· 15 citedOpen Access
Efficacy of Caspofungin against <i>Aspergillus flavus</i> , <i>Aspergillus terreus</i> , and <i>Aspergillus nidulans</i>
Antimicrobial Agents and Chemotherapy·2006· 36 citedOpen Access
Specific Substitutions in the Echinocandin Target Fks1p Account for Reduced Susceptibility of Rare Laboratory and Clinical <i>Candida</i> sp. Isolates
Antimicrobial Agents and Chemotherapy·2005· 426 citedOpen Access
Caspofungin versus amphotericin B treatment of<i>Aspergillus fumigatus</i>in kidneys of chronically immunosuppressed infected mice
Therapy·2005· 2 cited
Caspofungin versus amphotericin B treatment of Aspergillus fumigatus in kidneys of chronically immunosuppressed infected mice
Therapy·2005
A New Ene-triyne Antibiotic from the Fungus <i>Baeospora </i><i>m</i><i>yosura</i>
Journal of Natural Products·2004· 20 cited
Inactivation of Kex2p Diminishes the Virulence of Candida albicans
Journal of Biological Chemistry·2003· 78 citedOpen Access
Quantitative PCR Assay To Measure <i>Aspergillus fumigatus</i> Burden in a Murine Model of Disseminated Aspergillosis: Demonstration of Efficacy of Caspofungin Acetate
Antimicrobial Agents and Chemotherapy·2001· 208 citedOpen Access
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Frequent Co-authors

Amy Flattery(25), Ken Bartizal(14), Charles Gill(11), Christopher Gill(10), R.A. Giacobbe(10), James M. Balkovec(10), Robert A. Fromtling(10), Jennifer Nielsen Kahn(9), Gerald F. Bills(8), Cameron Douglas(7), Janet C. Onishi(7), L. Kong(7), Francisca Vicente(7), Jeffrey G. Smith(7), Paul Liberator(7), Gonzalo Platas(7), Martha Kurtz(6), Guy H. Harris(6), Myra B. Kurtz(6), Sarah Dreikorn(5)