David Granadier

Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa — South Africa

Immunology and Microbiology · Life Sciences

8h-index335citations29works11.32yr avg
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Research Topics

Immune Cell Function and Interaction(10), T-cell and B-cell Immunology(7), Hematopoietic Stem Cell Transplantation(6), Immunotherapy and Immune Responses(5), CAR-T cell therapy research(5)

Publications29 total

Damage-induced pyroptosis drives endogenous thymic regeneration by activating the purinergic receptor P2Y2
Cell Death and Disease·2026Open Access
Damage-induced IL-18 stimulates thymic NK cells limiting endogenous tissue regeneration
Nature Immunology·2025· 3 citedOpen Access
Endogenous thymic regeneration: restoring T cell production following injury
Nature reviews. Immunology·2025· 14 cited
Damage-induced IL-18 stimulates thymic NK Cells limiting endogenous tissue regeneration
2024· 2 citedOpen Access
Stem-like exhausted CD8 T cells in pleural effusions predict improved survival in non-small cell lung cancer (NSCLC) and mesothelioma
Translational Lung Cancer Research·2024· 4 citedOpen Access
Age-related epithelial defects limit thymic function and regeneration
Nature Immunology·2024· 67 citedOpen Access
Zinc Status Affects T Cell Reconstitution after Transplant in Patients Receiving Naïve-T Cell Depleted Allo-Transplants
Transplantation and Cellular Therapy·2024
Triggered: How Damage Induced IL-18 Suppresses Thymus Regeneration
Transplantation and Cellular Therapy·2024
Testing the Limits of Endogenous Thymic Regeneration after HCT Conditioning
Blood·2023Open Access
Zinc Status Affects T Cell Reconstitution in Patients Receiving Naïve T Cell Depleted Allogeneic HSCT
Blood·2023· 1 cited
Hematopoietic Stem Cell Transplantation (HCT) Conditioning Leads to NK Cell Cytotoxicity Limiting Endogenous Thymus Regeneration
Blood·2023· 1 citedOpen Access
Going oversized: Testing the limits of endogenous thymic regeneration and uncovering the mechanisms of thymic hypertrophy
The Journal of Immunology·2023Open Access
Interleukin 18 (IL-18) Suppresses Thymus Regeneration
The Journal of Immunology·2023Open Access
Damage-induced pyroptosis drives endogenous thymic regeneration via induction of Foxn1 by purinergic receptor activation
2023· 6 citedOpen Access
The Zinc-Sensing Receptor GPR39 Is a Master Regulator of Immune Reconstitution after Bone Marrow Transplant in the Thymus and in the Bone Marrow
Blood·2022
Interleukin 18 Suppresses Regeneration of the Thymus
Blood·2022· 3 cited
Cell autonomous metabolic remodeling governs regeneration of the thymus
The Journal of Immunology·2022
Activation of the zinc-sensing receptor GPR39 promotes T-cell reconstitution after hematopoietic cell transplant in mice
Blood·2022· 36 citedOpen Access
Age-related epithelial defects limit thymic function and regeneration
2021· 8 citedOpen Access
Attenuation of apoptotic cell detection triggers thymic regeneration after damage
Cell Reports·2021· 18 citedOpen Access
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Frequent Co-authors

Jarrod A. Dudakov(22), Kirsten Cooper(19), Lorenzo Iovino(19), Paul deRoos(18), Sinéad Kinsella(13), Cindy Evandy(13), Dante Acenas(9), Vanessa Hernández(8), Kayla Hopwo(7), Colton W Smith(7), Anastasia I. Kousa(5), Andri Leó Lemarquis(4), Marcel R.M. van den Brink(4), Steve Shannon-Sevillano(4), Jooho Chung(3), Eric Perkey(3), Ute Koch(3), Bruce R. Blazar(3), Freddy Radtke(3), Ivan Maillard(3)