Nareshkumar Jain

Global Engineering and Materials (United States) — United States

Medicine · Health Sciences

24h-index2.8kcitations58works0.52yr avg
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Research Topics

Microbial Natural Products and Biosynthesis(17), Synthetic Organic Chemistry Methods(16), Asymmetric Synthesis and Catalysis(14), Chemical Synthesis and Analysis(12), Estrogen and related hormone effects(8)

Publications58 total

Assessment of ADC Higher Order Structure Through 2D NMR Analysis
Molecules·2025· 1 citedOpen Access
Abstract 5741: siteDAR, complete antibody drug conjugate, ADC characterization
Cancer Research·2024
Non-cleavable Linkers: Permanently Linked, for Better or for Worse
2021· 1 cited
Antibody-Oligonucleotide Conjugates: A Twist to Antibody-Drug Conjugates
Journal of Clinical Medicine·2021· 117 citedOpen Access
Design and Synthesis of Isoquinolidinobenzodiazepine Dimers, a Novel Class of Antibody–Drug Conjugate Payload
ACS Medicinal Chemistry Letters·2017· 14 citedOpen Access
Eradication of Tumors through Simultaneous Ablation of CD276/B7-H3-Positive Tumor Cells and Tumor Vasculature
Cancer Cell·2017· 427 cited
Current ADC Linker Chemistry
Pharmaceutical Research·2015· 412 citedOpen Access
ChemInform Abstract: Total Synthesis of Vancomycin.
ChemInform·2010
ChemInform Abstract: Synthesis and SAR Study of Novel Pseudosteroids as Potent and Selective Progesterone Receptor Antagonists.
ChemInform·2009
Identification and Structure−Activity Relationships of Chromene-Derived Selective Estrogen Receptor Modulators for Treatment of Postmenopausal Symptoms
Journal of Medicinal Chemistry·2009· 99 citedOpen Access
Synthesis and SAR study of novel pseudo-steroids as potent and selective progesterone receptor antagonists
Bioorganic & Medicinal Chemistry Letters·2009· 10 citedOpen Access
Synthesis of Tetracyclic Heterocompounds as Selective Estrogen Receptor Modulators. Part 3. Development of an Acid-Catalyzed Racemization Process for (<i>S</i>)-2,8-(Dimethoxy)-5-{4-[2-(1-piperidinyl)ethoxy]phenyl}−11,12-dihydro-<i>5H</i>-6,13-dioxabenzo[3,4]cyclohepta[1,2-<i>a</i>]naphthalene
Organic Process Research & Development·2008· 2 cited
Insight from molecular modeling into different conformation and SAR of natural steroids and unnatural 7-oxa-steroids
Bioorganic & Medicinal Chemistry Letters·2008· 4 cited
Synthesis of Tetracyclic Heterocompounds as Selective Estrogen Receptor Modulators. Part 2. Process Improvement for Scale-Up of 2,5,8-Substituted 11,12-Dihydro-5<i>H</i>-6,13-dioxabenzo[3,4]cyclohepta-[1,2-<i>a</i>]naphthalene Derivatives
Organic Process Research & Development·2007· 7 cited
Synthesis, Structure−Activity Relationship and in Vivo Antiinflammatory Efficacy of Substituted Dipiperidines as CCR2 Antagonists
Journal of Medicinal Chemistry·2007· 25 citedOpen Access
Synthesis of Tetracyclic Heterocompounds as Selective Estrogen Receptor Modulators. Part 2. Process Improvement for Scale-Up Of 2,5,8-Substituted 11,12-Dihydro-5<i>H</i>-6,13-dioxabenzo[3,4]cyclohepta-[1,2-<i>a</i>]naphthalene Derivatives
Organic Process Research & Development·2007· 8 cited
Synthesis of Tetracyclic Heterocompounds as Selective Estrogen Receptor Modulators. Part 1. Process Development for Scale-up of 2,5,8-Substituted 5,11-Dihydrochromeno[4,3-<i>c</i>]chromene Derivatives
Organic Process Research & Development·2007· 11 cited
Parallel synthesis and SAR study of novel oxa-steroids as potent and selective progesterone receptor antagonists
Bioorganic & Medicinal Chemistry Letters·2007· 17 citedOpen Access
Synthesis and identification of novel oxa-steroids as progesterone receptor antagonists
Bioorganic & Medicinal Chemistry Letters·2006· 10 citedOpen Access
Enantioselective synthesis of (8S,13S,14R)-7-oxa-estra-4,9-diene-3,17-dione
Tetrahedron Letters·2006· 10 cited
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Frequent Co-authors

Zhihua Sui(17), James S. Panek(13), Swaminathan Natarajan(11), Robert Hughes(10), Toshikazu Bando(9), Joshi M. Ramanjulu(9), Masaru Takayanagi(8), Alexandros E. Koumbis(8), K. C. Nicolaou(7), Ronald K. Russell(7), Michael E. Solomon(6), George F. Allan(6), Scott G. Lundeen(6), K. C. Nicolaou(5), Michael Reuman(5), Fu‐An Kang(5), Jiayi Xu(5), Christopher N. Boddy(4), Ramesh M. Kanojia(4), Xun Li(4)