Xiaoguang Chen

Dalian Ocean University — China

Biochemistry, Genetics and Molecular Biology · Life Sciences

46h-index10.0kcitations355works2.92yr avg
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Research Topics

Natural product bioactivities and synthesis(34), Cancer therapeutics and mechanisms(22), Synthesis and biological activity(18), Cancer Treatment and Pharmacology(18), Crystallization and Solubility Studies(17)

Publications355 total

S1PR3 Inhibition in alveolar epithelial cells alleviates pulmonary fibrosis by enhancing alveolar barrier function
Respiratory Research·2025Open Access
Structure-enabled discovery of carboxylate esters prodrugs as potential potent inhibitors targeting Glutaminase C
Bioorganic Chemistry·2025
Protective effect of selenomethionine on spleen and sacculus rotundus injury induced by aflatoxin B1 in reserve male rabbits
Veterinary Research Communications·2025
Microbiome and Metabolomics Analysis Reveal the Interaction between Microbial Community and Metabolic Profiles in the Rhizosphere Soil of Invasive Amaranthus Palmeri
Journal of soil science and plant nutrition·2025· 1 cited
Discovery of bromobenzyl phenyl ether derivative YPD-29B: a novel pre-clinical compound targeting the programmed cell death-1/programmed cell death-ligand 1 (PD-1/PD-L1) interaction
Bioorganic & Medicinal Chemistry·2025
Deep Learning-Based Automated Body Composition Analysis Predicts Mortality in Peritoneal Dialysis Patients: A Retrospective Cohort Study
2025Open Access
Abstract 239: RCZY-690 and RCZY-680: Novel, highly potent, and orally bioavailable, tri-complex pan RAS-MULTI(ON) inhibitors with distinctive oral pharmacokinetic profiles, exhibiting broad anti-tumor activities in CDX models
Cancer Research·2025· 1 cited
Thermal proteome profiling (TPP) reveals NAMPT as the anti-glioma target of phenanthroindolizidine alkaloid PF403
Acta Pharmaceutica Sinica B·2025· 5 citedOpen Access
Tuning the Framework Al Distribution of ZSM-5 by Sn(IV) to Enhance the Catalytic Performance in 1-Hexene Cracking
Industrial & Engineering Chemistry Research·2025· 1 cited
Selenomethionine Attenuates Aflatoxin B<sub>1</sub>-induced Liver Injury by Modulating the Gut Microbiota and Metabolites in Rabbits
Journal of Agricultural and Food Chemistry·2025· 4 cited
Impact of biomechanical properties of tongue muscles on accuracy of English vowel pronunciation
Molecular & cellular biomechanics·2025Open Access
Discovery of Bromobenzyl Phenyl Ether Derivative Ypd-29b: A Novel Pre-Clinical Compound Targeting the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 (Pd-1/Pd-L1) Interaction
SSRN Electronic Journal·2025Open Access
Corrigendum to “Novel Nitric oxide-releasing derivatives of pyranocarbazole as antitumor agents: Design, synthesis, biological evaluation, and nitric oxide release studies” [Eur. J. Med. Chem. 244 (2022) 114832 / EJMECH-D-22-01635R2]
European Journal of Medicinal Chemistry·2024Open Access
Synthesis and Biological Evaluation of Novel <i>Psidium</i> Meroterpenoid Derivatives against Cisplatin-Induced Acute Kidney Injury
Journal of Medicinal Chemistry·2024· 7 citedOpen Access
Target fishing and mechanistic insights of the natural anticancer drug candidate chlorogenic acid
Acta Pharmaceutica Sinica B·2024· 24 citedOpen Access
Design, Synthesis, and Bioevaluation of Novel Reversibly Photoswitchable PI3K Inhibitors Based on Phenylazopyridine Derivatives toward Light-Controlled Cancer Treatment
Journal of Medicinal Chemistry·2024· 5 citedOpen Access
YPD-29B is an oral Small Molecular Targeting PD-L1 for Treating Human Cancers
2024Open Access
Discovery of Natural Ah Receptor Antagonists from <i>Salvia miltiorrhiza</i> Bunge and Synthesis of Analogs for Tumor Immunotherapy
Journal of Medicinal Chemistry·2024· 5 citedOpen Access
Dynamic gut microbiome-metabolome in cationic bovine serum albumin induced experimental immune-complex glomerulonephritis and effect of losartan and mycophenolate mofetil on microbiota modulation
Journal of Pharmaceutical Analysis·2023· 8 citedOpen Access
Rational design and optimization of novel 4-methyl quinazoline derivatives as PI3K/HDAC dual inhibitors with benzamide as zinc binding moiety for the treatment of acute myeloid leukemia
European Journal of Medicinal Chemistry·2023· 14 citedOpen Access
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Frequent Co-authors

Sen Zhang(8), Michael Chopp(7), Yi Li(6), Shuang‐Gang Ma(6), Jian‐Gong Shi(5), Jieli Chen(4), Subhash C. Gautam(4), Yongchun Yang(4), Shi‐Shan Yu(4), Jing Qu(4), Sheng Li(4), Dongming Zhang(4), Jingzhi Yang(4), Mark Katakowski(3), Lei Wang(3), Yongxian Xu(3), Nina Xue(3), Ming Ji(3), Sujuan Wang(3), Jiuming He(3)