Hyuk Lee

Korea Research Institute of Chemical Technology — South Korea

Biochemistry, Genetics and Molecular Biology · Life Sciences

24h-index2.2kcitations58works2.82yr avg
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Research Topics

Enzyme Catalysis and Immobilization(15), Catalytic C–H Functionalization Methods(12), Microbial Metabolic Engineering and Bioproduction(11), biodegradable polymer synthesis and properties(10), Asymmetric Hydrogenation and Catalysis(6)

Publications58 total

Targeting iron regulatory protein 2 (IRP2) to disrupt iron metabolism enhances radiosensitivity through mitochondrial dysfunction in breast cancer cells
Cell Death Discovery·2025Open Access
Discovery of a selective dual-specificity tyrosine phosphorylation-regulated kinase 1B inhibitor with anti-adipogenic and anti-diabetic activities
Frontiers in Pharmacology·2025Open Access
Correction: Inhibition of IRP2-dependent reprogramming of iron metabolism suppresses tumor growth in colorectal cancer
Cell Communication and Signaling·2024Open Access
Inhibition of IRP2-dependent reprogramming of iron metabolism suppresses tumor growth in colorectal cancer
Cell Communication and Signaling·2024· 14 citedOpen Access
Abstract 5937: KS20226, a first-in-class IRP2 inhibitor, preferentially induces reprogramming of iron metabolism and suppresses tumor growth in colorectal cancer
Cancer Research·2024
Radical hydrodifluoromethylation of unsaturated C−C bonds via an electroreductively triggered two-pronged approach
Communications Chemistry·2022· 24 citedOpen Access
KS10076, a chelator for redox-active metal ions, induces ROS-mediated STAT3 degradation in autophagic cell death and eliminates ALDH1+ stem cells
Cell Reports·2022· 12 citedOpen Access
Radical Hydrodifluoromethylation of Unsaturated C-C Bonds via an Electroreductively Triggered Two-pronged Approach
2022Open Access
Development of in vitro three-dimensional drug screening system for obesity-related metabolic syndrome
Journal of Pharmacological Sciences·2022· 7 citedOpen Access
Synthesis of novel 1H-Pyrazolo[3,4-b]pyridine derivatives as DYRK 1A/1B inhibitors
Bioorganic & Medicinal Chemistry Letters·2021· 15 citedOpen Access
Synthesis of 1<i>H</i>-Indazoles via Silver(I)-Mediated Intramolecular Oxidative C–H Bond Amination
ACS Omega·2021· 13 citedOpen Access
707 Discovery of a novel EP2 and EP4 dual antagonist
Regular and Young Investigator Award Abstracts·2020· 1 citedOpen Access
Copper‐Catalyzed 1,2‐Bistrifluoromethylation of Terminal Alkenes
Advanced Synthesis & Catalysis·2019· 17 cited
Structural and Experimental Evidence for the Enantiomeric Recognition toward a Bulky <i>sec</i>-Alcohol by <i>Candida antarctica</i> Lipase B
ACS Catalysis·2016· 29 cited
Biosynthesis of poly(2‐hydroxyisovalerate‐co‐lactate) by metabolically engineered <i>Escherichia coli</i>
Biotechnology Journal·2016· 28 cited
The discovery and the structural basis of an imidazo[4,5-b]pyridine-based p21-activated kinase 4 inhibitor
Bioorganic & Medicinal Chemistry Letters·2016· 21 citedOpen Access
One-step fermentative production of poly(lactate-co-glycolate) from carbohydrates in Escherichia coli
Nature Biotechnology·2016· 227 cited
Small molecule inhibitors of the Dishevelled‐ <scp>CXXC</scp> 5 interaction are new drug candidates for bone anabolic osteoporosis therapy
EMBO Molecular Medicine·2016· 45 citedOpen Access
Biosynthesis of poly(2-hydroxybutyrate-co-lactate) in metabolically engineered Escherichia coli
Biotechnology and Bioprocess Engineering·2016· 28 cited
Discovery of Tyk2 inhibitors via the virtual site-directed fragment-based drug design
Bioorganic & Medicinal Chemistry Letters·2015· 14 citedOpen Access
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Frequent Co-authors

Si Jae Park(9), Chul‐Ho Jun(8), Sang Yup Lee(8), Jung Eun Yang(7), Bong Keun Song(7), Bum‐Tae Kim(7), Young Hoon Oh(7), Seung Hwan Lee(6), Areum Park(6), Jung‐Nyoung Heo(5), Kyu‐Sung Jeong(5), Jihoon Shin(4), Jun‐Bae Hong(4), Keehoon Won(4), A‐Reum Park(4), SangYoun Park(4), Seongsoon Park(4), Ki Young Kim(4), Sang Joon Shin(4), So Young Choi(3)