Manchugondanahalli S. Krishna

University of Notre Dame — United States

Materials Science · Physical Sciences

16h-index651citations57works1.52yr avg
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Research Topics

Crystallization and Solubility Studies(17), RNA and protein synthesis mechanisms(16), X-ray Diffraction in Crystallography(16), DNA and Nucleic Acid Chemistry(11), RNA Interference and Gene Delivery(9)

Publications57 total

Eight Triplex-Binding Molecules from Four Chemical Classes Broadly Recognize the MALAT1 Triple Helix
Molecules·2025Open Access
A dual-affinity peptide nucleic acid for targeting miRNA-21 precursor rescues tumor repressor PTEN expression
Cell Reports Physical Science·2025Open Access
A new dual-affinity peptide nucleic acid for targeting miRNA-21 precursor rescues tumor repressor PTEN expression
2025Open Access
Towards the Development of Isoenergetic Peptide Nucleic Acid Based Probes Targeting Double-Stranded RNAs Through Enhancing Sequence-Specific Stacking Interactions
2025Open Access
Best Practices for Variant Calling Using the Genome Analysis Toolkit
2025· 2 cited
Structural Elucidation of an RNA Triple Helix in Complex with a Small Molecule
Structural Dynamics·2025Open Access
A New Dual-Affinity Peptide Nucleic Acid for Targeting miRNA-21 Precursor Rescues Tumor Repressor PTEN Expression
SSRN Electronic Journal·2025Open Access
Towards the Development of Isoenergetic Peptide Nucleic Acid Based Probes Targeting Double-Stranded RNAs Through Enhancing Sequence-Specific Stacking Interactions
SSRN Electronic Journal·2025Open Access
Recognition of RNA secondary structures with a programmable peptide nucleic acid-based platform
Cell Reports Physical Science·2024· 7 citedOpen Access
Enhanced Recognition of a Herbal Compound Epiberberine by a DNA Quadruplex-Duplex Structure
Analytical Chemistry·2024· 4 cited
Recognition of RNA secondary structures with a programmable peptide nucleic acid-based platform
2024· 1 citedOpen Access
Enhanced Recognition of a Herbal Compound Epiberberine by a DNA Quadruplex-Duplex Structure
2024Open Access
Locked Nucleic Acid Oligonucleotides Facilitate RNA•LNA-RNA Triple-Helix Formation and Reduce MALAT1 Levels
International Journal of Molecular Sciences·2024· 6 citedOpen Access
Structural characterization of a small-molecule RNA triple helix complex
Acta Crystallographica Section A Foundations and Advances·2023Open Access
Langlois Reagent Mediated Tandem Cyclization of o-Hydroxyaryl Enaminones for the Synthesis of 3-(Trifluoromethyl)chromones
Synlett·2022· 6 cited
Targeting RNA Editing of Antizyme Inhibitor 1: a Potential Oligonucleotide-Based Antisense Therapy for Cancer.
2021
Targeting RNA editing of antizyme inhibitor 1: A potential oligonucleotide-based antisense therapy for cancer
Molecular Therapy·2021· 33 citedOpen Access
Tertiary Base Triple Formation in the SRV-1 Frameshifting Pseudoknot Stabilizes Secondary Structure Components
Biochemistry·2020· 10 cited
Incorporating G-C Pair-Recognizing Guanidinium into PNAs for Sequence and Structure Specific Recognition of dsRNAs over dsDNAs and ssRNAs
Biochemistry·2019· 21 citedOpen Access
Incorporating 2-Thiouracil into Short Double-Stranded RNA-Binding Peptide Nucleic Acids for Enhanced Recognition of A-U Pairs and for Targeting a MicroRNA Hairpin Precursor
Biochemistry·2019· 22 cited
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Frequent Co-authors

Gang Chen(17), Desiree‐Faye Kaixin Toh(14), Kiran M. Patil(12), Alan Ann Lerk Ong(11), Jarugu Narasimha Moorthy(8), Yun Lian(8), Xuan Zhan(8), Ruiyu Lin(7), Rongguang Lu(7), Palani Natarajan(6), H. Nagarajaiah(6), P. Venugopalan(6), Lixia Yang(5), Zhenyu Meng(5), Yunpeng Lu(5), Xin Ke(5), Hongwei Wang(5), Jean‐Luc Décout(4), Kun Xi(4), Yanyu Chen(4)