Funian Lu

Tongji Hospital — China

Biochemistry, Genetics and Molecular Biology · Life Sciences

21h-index1.3kcitations56works7.52yr avg
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Research Topics

Cancer Genomics and Diagnostics(14), PARP inhibition in cancer therapy(10), Ovarian cancer diagnosis and treatment(9), Endometrial and Cervical Cancer Treatments(8), Cancer Immunotherapy and Biomarkers(6)

Publications56 total

The low-dose CHK1 inhibitor prexasertib triggers VDAC1 dephosphorylation to activate mtDNA-STING signaling and synergize immunotherapy
Cell Reports·2025· 5 citedOpen Access
Heterogeneous cellular responses to hyperthermia support combined intraperitoneal hyperthermic immunotherapy for ovarian cancer mouse models
Science Translational Medicine·2025· 5 cited
Genomic profiling of a multi-lineage and multi-passage patient-derived xenograft biobank reflects heterogeneity of ovarian cancer
Cell Reports Medicine·2024· 2 citedOpen Access
Proteogenomic insights into early-onset endometrioid endometrial carcinoma: predictors for fertility-sparing therapy response
Nature Genetics·2024· 18 cited
Comprehensive multi-omics analysis reveals WEE1 as a synergistic lethal target with hyperthermia through CDK1 super-activation
Nature Communications·2024· 15 citedOpen Access
344 A genomically and clinically annotated patient-derived xenograft library for ovarian cancer research
2024
Multiomic analysis of cervical squamous cell carcinoma identifies cellular ecosystems with biological and clinical relevance
Nature Genetics·2023· 54 cited
MRE11:p.K464R mutation mediates olaparib resistance by enhancing DNA damage repair in HGSOC
Cell & Bioscience·2023· 4 citedOpen Access
<i>STAT4</i>, a potential predictor of prognosis, promotes CD8 T‑cell infiltration in ovarian serous carcinoma by inducing CCL5 secretion
Oncology Reports·2023· 11 citedOpen Access
Large language models completely understand molecular characteristics of squamous cervical cancer
2023· 1 citedOpen Access
Multidimensional Molecular Characteristics of Early-Onset Endometrioid Endometrial Carcinoma, And Potential Predictors Of Response To Fertility Sparing Therapy
2023Open Access
Multi-omics characterization of cellular state diversity and bidirectional tumor-stroma/immune interactions in cervical squamous cell carcinoma
2023· 1 citedOpen Access
BRD4 inhibition impairs DNA mismatch repair, induces mismatch repair mutation signatures and creates therapeutic vulnerability to immune checkpoint blockade in MMR-proficient tumors
Journal for ImmunoTherapy of Cancer·2023· 16 citedOpen Access
Supplementary Data from MEK Inhibition Remodels the Immune Landscape of Mutant &lt;i&gt;KRAS&lt;/i&gt; Tumors to Overcome Resistance to PARP and Immune Checkpoint Inhibitors
2023Open Access
Supplementary Data from MEK Inhibition Remodels the Immune Landscape of Mutant &lt;i&gt;KRAS&lt;/i&gt; Tumors to Overcome Resistance to PARP and Immune Checkpoint Inhibitors
2023Open Access
Data from MEK Inhibition Remodels the Immune Landscape of Mutant &lt;i&gt;KRAS&lt;/i&gt; Tumors to Overcome Resistance to PARP and Immune Checkpoint Inhibitors
2023Open Access
Data from MEK Inhibition Remodels the Immune Landscape of Mutant &lt;i&gt;KRAS&lt;/i&gt; Tumors to Overcome Resistance to PARP and Immune Checkpoint Inhibitors
2023Open Access
Additional file 6 of MRE11:p.K464R mutation mediates olaparib resistance by enhancing DNA damage repair in HGSOC
Figshare·2023Open Access
Additional file 7 of MRE11:p.K464R mutation mediates olaparib resistance by enhancing DNA damage repair in HGSOC
Figshare·2023Open Access
Additional file 8 of MRE11:p.K464R mutation mediates olaparib resistance by enhancing DNA damage repair in HGSOC
Figshare·2023Open Access
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Frequent Co-authors

Gang Chen(40), Chaoyang Sun(36), Rourou Xiao(35), Tianyu Qin(32), Bin Yang(29), Yu Fu(28), Junpeng Fan(26), Ensong Guo(22), Chen Liu(19), Zizhuo Wang(17), Xi Li(17), Dianxing Hu(17), Fuxia Li(15), Lixin You(15), Si Liu(15), Gordon B. Mills(15), Xiaohang Yang(13), Xucui Zhuang(13), Jingjing Yin(12), Wenting Li(11)