Keiichi Higuchi

Shinshu University — Japan

Biochemistry, Genetics and Molecular Biology · Life Sciences

45h-index8.2kcitations234works5.32yr avg
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Research Topics

Amyloidosis: Diagnosis, Treatment, Outcomes(92), Alzheimer's disease research and treatments(61), Prion Diseases and Protein Misfolding(34), Genetics, Aging, and Longevity in Model Organisms(22), Trace Elements in Health(22)

Publications231 total

Effects of lifetime supplementation with ubiquinol 10 on the lifespan and progression of aging in female C57BL/6 mice
Experimental Gerontology·2025Open Access
Cryo-EM Observation of AA Amyloid Fibrils in Mouse Model of Systemic AApoAII Amyloidosis
Journal of Molecular Biology·2025Open Access
Classification of amyloidosis and protein misfolding disorders in animals 2024: A review on pathology and diagnosis
Veterinary Pathology·2024· 14 cited
Insights into the Structural Basis of Amyloid Resistance Provided by Cryo-EM Structures of AApoAII Amyloid Fibrils
Journal of Molecular Biology·2024· 7 citedOpen Access
Renal Function in Aged C57BL/6J Mice Is Impaired by Deposition of Age-Related Apolipoprotein A-II Amyloid Independent of Kidney Aging
American Journal Of Pathology·2023· 9 citedOpen Access
BALB.NCT-Cpox is a unique mouse model of hereditary coproporphyria
Molecular Genetics and Metabolism Reports·2023Open Access
Macrophages in the reticuloendothelial system inhibit early induction stages of mouse apolipoprotein A-II amyloidosis
Amyloid·2022· 1 cited
Exercise suppresses mouse systemic AApoAII amyloidosis through enhancement of the p38 MAPK signaling pathway
Disease Models & Mechanisms·2022· 9 citedOpen Access
Polygenic control of the wavy coat of the NCT mouse: involvement of an intracisternal A particle insertional mutation of the protease, serine 53 (Prss53) gene, and a modifier gene
Mammalian Genome·2022
Macrophages in the reticuloendothelial system inhibit early induction stages of mouse apolipoprotein A-II amyloidosis
Figshare·2022Open Access
Involvement of increased endoplasmic reticulum stress in the development of cataracts in BALB.NCT-Cpox mice
Experimental Eye Research·2021· 5 citedOpen Access
Macrophages in the reticuloendothelial system inhibit the propagation phase of mouse apolipoprotein A-II amyloidosis
2021Open Access
Glavonoid-rich oil supplementation reduces stearoyl-coenzyme A desaturase 1 expression and improves systemic metabolism in diabetic, obese KK-A mice
Biomedicine & Pharmacotherapy·2021· 7 citedOpen Access
Development of diagnostic antibodies against immunoglobulin heavy chain variable region for heavy chain amyloidosis (AH amyloidosis)
Pathology International·2021· 2 cited
Curcumin promotes AApoAII amyloidosis and peroxisome proliferation in mice by activating the PPARα signaling pathway
eLife·2021· 22 citedOpen Access
Author response: Curcumin promotes AApoAII amyloidosis and peroxisome proliferation in mice by activating the PPARα signaling pathway
2021Open Access
Curcumin promotes progression of AApoAII amyloidosis and peroxisome proliferation in mice by activating the PPARα signaling pathway
2020Open Access
Dialysis-related amyloidosis associated with a novel β<sub>2</sub>-microglobulin variant
Amyloid·2020· 21 citedOpen Access
Dialysis-related amyloidosis associated with a novel β<sub>2</sub>-microglobulin variant
Figshare·2020Open Access
Reduced Coenzyme Q10 Decelerates Senescence and Age-Related Hearing Loss in Senescence-Accelerated Mice by Activating Mitochondrial Functions.
2020· 1 cited
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Frequent Co-authors

Masanori Hosokawa(20), Toshio Takeda(15), Masayuki Mori(13), Hironobu Naiki(10), Jinko Sawashita(8), T. Takeda(8), Takatoshi Matsushita(7), Xiaoying Fu(6), Kaori Kitagawa(6), Kazunori Hosoe(5), Kumiko Kogishi(5), Masakiyo Hosokawa(5), Yanming Xing(5), Mutsumi Matsushita(4), Atsuko Matsumura(4), Fuyuki Kametani(4), Junjie Yao(4), Hiroshi Kubo(4), N Meglin(4), H. Bryan Brewer(4)