Hong-Bing Shu

Wuhan University — China

Immunology and Microbiology · Life Sciences

16h-index9.1kcitations22works5.42yr avg
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Research Topics

interferon and immune responses(12), NF-κB Signaling Pathways(9), Cell death mechanisms and regulation(6), Immune Response and Inflammation(6), Viral Infections and Vectors(5)

Publications21 total

Physalin F Promotes AFG3L2-Mediated Degradation of VISA/MAVS to Suppress Innate Immune Response to RNA Virus
Pathogens·2026Open Access
Intercepting the Downstream of the Estrogen Receptor Signaling Pathway: Discovery of a Potent and Efficient SRC-3 PROTAC Degrader for Overcoming Endocrine Resistance Breast Cancer
Journal of Medicinal Chemistry·2025· 5 cited
MARCH8 Mediates K27-Linked Polyubiquitination of IL-7 Receptor α to Negatively Regulate IL-7–Triggered T Cell Homeostasis
The Journal of Immunology·2024· 3 cited
PLK2-mediated phosphorylation of SQSTM1 S349 promotes aggregation of polyubiquitinated proteins upon proteasomal dysfunction
Autophagy·2024· 6 citedOpen Access
Viral infection and spread are inhibited by the polyubiquitination and downregulation of TRPV2 channel by the interferon-stimulated gene TRIM21
Cell Reports·2024· 13 citedOpen Access
Human Cytomegalovirus Tegument Protein UL82 Inhibits STING-Mediated Signaling to Evade Antiviral Immunity
Cell Host & Microbe·2017· 190 citedOpen Access
The ER-Associated Protein ZDHHC1 Is a Positive Regulator of DNA Virus-Triggered, MITA/STING-Dependent Innate Immune Signaling
Cell Host & Microbe·2014· 147 citedOpen Access
NLRC3, a Member of the NLR Family of Proteins, Is a Negative Regulator of Innate Immune Signaling Induced by the DNA Sensor STING
Immunity·2014· 264 citedOpen Access
Hepatitis C virus NS4B blocks the interaction of STING and TBK1 to evade host innate immunity
Journal of Hepatology·2013· 184 cited
USP2a positively regulates TCR-induced NF-κB activation by bridging MALT1-TRAF6
Protein & Cell·2012· 28 citedOpen Access
LSm14A is a processing body-associated sensor of viral nucleic acids that initiates cellular antiviral response in the early phase of viral infection
Proceedings of the National Academy of Sciences·2012· 151 citedOpen Access
Protein Kinase C-δ Negatively Regulates T Cell Receptor-induced NF-κB Activation by Inhibiting the Assembly of CARMA1 Signalosome
Journal of Biological Chemistry·2012· 16 citedOpen Access
Resistance to Inhibitors of Cholinesterase-8A (Ric-8A) Is Critical for Growth Factor Receptor-induced Actin Cytoskeletal Reorganization
Journal of Biological Chemistry·2011· 33 citedOpen Access
Glycogen Synthase Kinase 3β Regulates IRF3 Transcription Factor-Mediated Antiviral Response via Activation of the Kinase TBK1
Immunity·2010· 176 citedOpen Access
The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3 Transcription Factor Activation
Immunity·2008· 1.5k citedOpen Access
Syntenin negatively regulates TRAF6-mediated IL-1R/TLR4 signaling
Cellular Signalling·2007· 26 cited
A20 is a potent inhibitor of TLR3‐ and Sendai virus‐induced activation of NF‐κB and ISRE and IFN‐β promoter
FEBS Letters·2004· 120 cited
Crystal Structure of sTALL-1 Reveals a Virus-like Assembly of TNF Family Ligands
Cell·2002· 197 citedOpen Access
The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex
Proceedings of the National Academy of Sciences·1996· 420 citedOpen Access
TNF-Dependent Recruitment of the Protein Kinase RIP to the TNF Receptor-1 Signaling Complex
Immunity·1996· 1.2k citedOpen Access
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Frequent Co-authors

Shuai Wang(5), Bo Zhong(4), Shu Li(4), Yanyi Wang(4), David V. Goeddel(3), Hailing Hsu(2), Xiao He(2), Lu Zhang(2), Qian Zhou(2), Zhonghe Zhai(2), Yi Li(2), Xuemei Yi(2), Ming-Gui Pan(1), Yan Yang(1), Ying Li(1), Feici Diao(1), Cao‐Qi Lei(1), Po Tien(1), Jianing Huang(1), Vijay Baichwal(1)