Shigeru Sakiyama

Immunology and Microbiology · Life Sciences

34h-index4.3kcitations133works0.02yr avg
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Research Topics

Immunotherapy and Immune Responses(20), Virus-based gene therapy research(20), Cancer-related Molecular Pathways(19), Neuroblastoma Research and Treatments(16), Immune Cell Function and Interaction(11)

Publications133 total

Elevated expression of DNA polymerase κ in human lung cancer is associated with p53 inactivation: Negative regulation of POLK promoter activity by p53
International Journal of Oncology·2004· 37 cited
Midkine Promoter Can Mediate Transcriptional Activation of a Fused Suicide Gene in a Broader Range of Human Breast Cancer Compared with c-erbB-2 Promoter
Oncology·2004· 14 cited
DNA polymerase θ is preferentially expressed in lymphoid tissues and upregulated in human cancers
International Journal of Cancer·2003· 141 cited
Transduction of the IL-21 and IL-23 genes in human pancreatic carcinoma cells produces natural killer cell-dependent and -independent antitumor effects
Cancer Gene Therapy·2003· 72 cited
Cell growth- and P53-dependent transcriptional activity of the midkine promoter confers suicide gene expression in tumor cells
Oncology Reports·2003· 14 cited
Expression profiling and characterization of 4200 genes cloned from primary neuroblastomas: identification of 305 genes differentially expressed between favorable and unfavorable subsets
Oncogene·2003· 78 cited
Glioma-specific cytotoxic T cells can be effectively induced by subcutaneous vaccination of irradiated wild-type tumor cells without artificial cytokine production
International Journal of Oncology·2003· 7 cited
Inhibition of metastatic brain tumor growth by intramuscular administration of the endostatin gene
International Journal of Oncology·2003· 19 cited
Accumulation of p27KIP1 is associated with BMP2-induced growth arrest and neuronal differentiation of human neuroblastoma-derived cell lines
Biochemical and Biophysical Research Communications·2003· 50 cited
T-cell-dependent antitumor effects produced by CD40 ligand expressed on mouse lung carcinoma cells are linked with the maturation of dendritic cells and secretion of a variety of cytokines
Cancer Gene Therapy·2003· 16 citedOpen Access
Utilization of the promoter region of the midkine gene as a tool to drive therapeutic genes in a tumor specific manner
Advances in Enzyme Regulation·2003· 7 cited
Expression of the interleukin-21 gene in murine colon carcinoma cells generates systemic immunity in the inoculated hosts
Cancer Gene Therapy·2003· 80 cited
Fas ligand-expressing tumors induce tumor-specific protective immunity in the inoculated hosts but vaccination with the apoptotic tumors suppresses antitumor immunity
Cancer Gene Therapy·2003· 6 citedOpen Access
Interleukin-12-mediated induction of systemic immunity in the periphery and recruitment of activated T cells into the brain produce limited antitumor effects compared with interleukin-2
International Journal of Molecular Medicine·2002· 4 cited
Cutting Edge: A Novel Role for Fas Ligand in Facilitating Antigen Acquisition by Dendritic Cells
The Journal of Immunology·2002· 26 cited
p73-dependent expression of DAN during cisplatin-induced cell death and osteoblast differentiation
Biochemical and Biophysical Research Communications·2002· 10 cited
A promoter region of midkine gene can activate transcription of an exogenous suicide gene in human pancreatic cancer.
PubMed·2002· 12 cited
Identification of the small interstitial deletion at chromosome band 1p34–p35 and its association with poor outcome in oligodendroglial tumors
Genes Chromosomes and Cancer·2002· 38 cited
Secretion of interleukin-10 from murine colon carcinoma cells suppresses systemic antitumor immunity and impairs protective immunity induced against the tumors
Cancer Gene Therapy·2002· 6 cited
DAN Gene
Elsevier eBooks·2002
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Frequent Co-authors

Masatoshi Tagawa(16), Yohko Nakamura(10), Akira Nakagawara(10), Keizo Takenaga(9), Kiyoko Kawamura(8), Hajime Kageyama(6), Toshinori Ozaki(6), Hiroki Namba(6), Yasuo Iwadate(6), Tomotane Shishikura(5), Miki Ohira(5), Takaki Hiwasa(5), Shingo Ichimiya(4), Naohiko Seki(4), Hiromitsu Saisho(4), Motohiro Miyauchi(4), Rumana Bahar(3), Jiyang O‐Wang(3), Shigeyuki Yokoyama(3), Taketo Yamaguchi(3)