Jun Takayama

Josai University — Japan

Chemistry · Physical Sciences

16h-index1.7kcitations78works0.62yr avg
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Research Topics

Oxidative Organic Chemistry Reactions(12), Organic Chemistry Cycloaddition Reactions(12), Crystallization and Solubility Studies(11), HIV/AIDS drug development and treatment(8), X-ray Diffraction in Crystallography(8)

Publications78 total

Genetic regulation across germline and somatic variation on the Y chromosome contributes to type 2 diabetes
Nature Medicine·2026Open Access
Polyamine metabolism as a regulator of cellular and organismal aging
Amino Acids·2026Open Access
Palette polygenic risk score framework improves risk prediction by capturing clinical heterogeneity of type 2 diabetes
2026Open Access
Design and Synthesis of Ferulic Acid Derivatives with Enhanced Antioxidant and Neuroprotective Activities: Discovery of Dual Antioxidant Agent
AppliedChem·2025Open Access
FAD012, a Ferulic Acid Derivative, Preserves Cerebral Blood Flow and Blood–Brain Barrier Integrity in the Rat Photothrombotic Stroke Model
Biomedicines·2025· 1 citedOpen Access
CUD003, a Novel Curcumin Derivative, Ameliorates LPS-Induced Impairment of Endothelium-Dependent Relaxation and Vascular Inflammation in Mice
International Journal of Molecular Sciences·2025· 2 citedOpen Access
Chronic Administration with FAD012 (3,5-Dimethyl-4-hydroxycinnamic Acid) Maintains Cerebral Blood Flow and Ameliorates Swallowing Dysfunction After Chronic Cerebral Hypoperfusion in Rats
International Journal of Molecular Sciences·2025· 2 citedOpen Access
Prediction of Pharmacological Activity by Machine Learning Using Molecular Orbital Energy as an Explanatory Variable
Journal of Computer Chemistry Japan·2024Open Access
Involvement of the Restoration of Cerebral Blood Flow and Maintenance of eNOS Expression in the Prophylactic Protective Effect of the Novel Ferulic Acid Derivative FAD012 against Ischemia/Reperfusion Injuries in Rats
International Journal of Molecular Sciences·2023· 11 citedOpen Access
FAD012 reduces blood-brain-barrier damage in photothrombotic stroke rats.
Proceedings for Annual Meeting of The Japanese Pharmacological Society·2023Open Access
Repeated prophylactic treatment of a curcumin derivative CUD003 prevents lipopolysaccharide-induced depressive-like behavior by inhibiting excessive inflammation in mice.
Proceedings for Annual Meeting of The Japanese Pharmacological Society·2023Open Access
Anti-amnesic effect of CUD 003, a novel synthetic derivative of curcumin, on scopolamine-induced memory impairment in rats
Proceedings for Annual Meeting of The Japanese Pharmacological Society·2022Open Access
Prediction of molecular properties with machine learning and molecular orbital energies
AIP conference proceedings·2022· 3 cited
Machine Learning Study of Antioxidant Effects with Molecular Orbital Energies as Explanatory Variables
Journal of Computer Chemistry Japan·2022· 2 citedOpen Access
CCDC 2034188: Experimental Crystal Structure Determination
The Cambridge Structural Database·2021Open Access
A study of enantioselective syntheses by Sharpless asymmetric oxidation for aryl sulfoxides containing oxygen groups at the ortho position
Journal of Chemical Sciences·2021· 2 cited
CUD003, a novel synthetic derivative of curcumin, can mitigate middle cerebral artery occlusion (MCAO)-induced ischemic injury by suppressing inflammation in rats
Proceedings for Annual Meeting of The Japanese Pharmacological Society·2021Open Access
Improvement of the Solubility and Evaluation of the Physical Properties of an Inclusion Complex Formed by a New Ferulic Acid Derivative and γ-Cyclodextrin
ACS Omega·2020· 25 citedOpen Access
Prediction of Molecular Properties by Molecular Orbital Calculations and Machine Learning
Journal of Computer Chemistry Japan·2020· 2 citedOpen Access
Involvement of serotonergic system in the antidepressant-like effect of a novel curcumin derivative CUD003 in mice
Proceedings for Annual Meeting of The Japanese Pharmacological Society·2020Open Access
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Frequent Co-authors

Meiyan Xuan(14), Mari Okazaki(13), Arun K. Ghosh(11), Takeshi Sakamoto(11), Juzo Nakayama(7), Yoshiaki Sugihara(7), Akihiko Ishii(7), Toshio Honda(6), Hiroyuki Teramae(6), Hirotake Mizutani(5), Hirokazu Matsuzaki(5), Kiira Ratia(4), Susan C. Baker(4), Andrew D. Mesecar(4), Hiroaki Mitsuya(4), Bo Yuan(4), Takeshi Sakamoto(4), Rima Chaudhuri(3), Michael E. Johnson(3), Yukio Soeda(3)