Kohtaro Minami

Medicine · Health Sciences

28h-index4.0kcitations100works2.62yr avg
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Research Topics

Pancreatic function and diabetes(43), Lysosomal Storage Disorders Research(26), Glycogen Storage Diseases and Myoclonus(20), Diabetes and associated disorders(16), Diabetes Management and Research(13)

Publications100 total

A transferrin receptor-targeted α-L-fucosidase, JR-471, reduced core-fucosylated glycoasparagine in the brain and preserved motor function in a murine model of fucosidosis
Molecular Genetics and Metabolism·2026
PARTICLE-BASED SIMULATION ON SCOURING PROCESS OF SAND AND GRAVEL LAYERS DUE TO VERTICAL JET USING DEM AND ELASTOPLASTIC MODEL
Japanese Journal of JSCE·2025
Recovery of retinal function in MPS II mice by treatment with pabinafusp alfa
Molecular Genetics and Metabolism·2024
Enzyme replacement therapy with a blood brain barrier-penetrating antibody-fused alpha-L-iduronidase prevents bone deformities in a mouse model of mucopolysaccharidosis type I
Molecular Genetics and Metabolism·2024
α-L-iduronidase fused with humanized anti-human transferrin receptor antibody (lepunafusp alfa) for mucopolysaccharidosis type I: A phase 1/2 trial
Molecular Therapy·2024· 13 citedOpen Access
Transferrin Receptor-Targeted Iduronate-2-sulfatase Penetrates the Blood-Retinal Barrier and Improves Retinopathy in Mucopolysaccharidosis II Mice
Molecular Pharmaceutics·2023· 6 citedOpen Access
Enzyme replacement with transferrin receptor-targeted α-L-iduronidase rescues brain pathology in mucopolysaccharidosis I mice
Molecular Therapy — Methods & Clinical Development·2023· 23 citedOpen Access
Life-span extension in Krabbe disease mice by treatment with a transferrin receptor-targeted galactocerebrosidase
Molecular Genetics and Metabolism·2023
A fusion protein of anti-human transferrin receptor antibody and alfa-L-fucosidase 1 is a prospective candidate for the treatment of the symptoms in CNS and visceral tissues of fucosidosis
Molecular Genetics and Metabolism·2023
Intravenous treatment with pabinafusp alfa dose-dependently prevents neurological impairment and bone deformities in a mouse model of mucopolysaccharidosis type II
Molecular Genetics and Metabolism·2023
Nonclinical pharmacodynamics, pharmacokinetics and safety profiles of anti-human transferrin receptor antibody-fused N-sulfoglucosamine sulfohydrolase for mucopolysaccharidosis type IIIA
Molecular Genetics and Metabolism·2023
IZCARGO<sup>Ⓡ</sup>: the world's first biological drug applied with brain drug delivery technology
Drug Delivery System·2023· 2 citedOpen Access
Pathogenic Roles of Heparan Sulfate and Its Use as a Biomarker in Mucopolysaccharidoses
International Journal of Molecular Sciences·2022· 16 citedOpen Access
Pharmacokinetics and pharmacodynamics of once-weekly administration of JR-142, a long-acting albumin-fused human growth hormone: A rondemized, placebo-controlled phase 1 study
Growth Hormone & IGF Research·2022· 2 citedOpen Access
Treatment of Neuronopathic Mucopolysaccharidoses with Blood–Brain Barrier-Crossing Enzymes: Clinical Application of Receptor-Mediated Transcytosis
Pharmaceutics·2022· 25 citedOpen Access
Dose-dependent effects of a brain-penetrating iduronate-2-sulfatase on neurobehavioral impairments in mucopolysaccharidosis II mice
Molecular Therapy — Methods & Clinical Development·2022· 12 citedOpen Access
Efficacy of an anti-human transferrin receptor antibody-fused N-sulfoglucosamine sulfohydrolase in mucopolysaccharidosis type IIIA mice
Molecular Genetics and Metabolism·2022
Enzyme replacement with a blood-brain barrier-penetrating antibody-fused alfa-L-iduronidase prevents neurobehavioral performance of mucopolysaccharidosis type I mice
Molecular Genetics and Metabolism·2022
Drug delivery for neuronopathic lysosomal storage diseases: evolving roles of the blood brain barrier and cerebrospinal fluid
Metabolic Brain Disease·2022· 20 citedOpen Access
Enzyme Replacement Therapy with Pabinafusp Alfa for Neuronopathic Mucopolysaccharidosis II: An Integrated Analysis of Preclinical and Clinical Data
International Journal of Molecular Sciences·2021· 39 citedOpen Access
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Frequent Co-authors

Susumu Seino(26), Takashi Miki(13), Hiroyuki Sonoda(10), Norihide Yokoi(8), Tohru Hirato(8), Harumi Takahashi(7), Tadao Shibasaki(6), Hideto Morimoto(6), Ryûji Yamamoto(6), Yuji Sato(5), Masahiro Iwasaki(4), Eiji Yoden(4), Masafumi Kinoshita(4), Akira Mizoguchi(4), Kenichi Takahashi(4), Kazunori Tanizawa(4), Mathias Schmidt(4), Atsushi Imakiire(4), Atsunori Saraya(3), Akinori Okumachi(3)