W. A. Large

St George's, University of London — United Kingdom

Biochemistry, Genetics and Molecular Biology · Life Sciences

44h-index5.7kcitations127works0.02yr avg
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Research Topics

Ion channel regulation and function(90), Cardiac electrophysiology and arrhythmias(43), Neuroscience and Neuropharmacology Research(40), Ion Channels and Receptors(40), Neuroscience and Neural Engineering(27)

Publications127 total

Obligatory role for PKCδ in PIP<sub>2</sub>‐mediated activation of store‐operated TRPC1 channels in vascular smooth muscle cells
The Journal of Physiology·2020· 13 citedOpen Access
Insights into Activation Mechanisms of Store-Operated TRPC1 Channels in Vascular Smooth Muscle
Cells·2020· 15 citedOpen Access
Evidence that Orai1 does not contribute to store-operated TRPC1 channels in vascular smooth muscle cells
Channels·2017· 23 citedOpen Access
Store‐operated interactions between plasmalemmal STIM1 and TRPC1 proteins stimulate PLCβ1 to induce TRPC1 channel activation in vascular smooth muscle cells
The Journal of Physiology·2016· 36 citedOpen Access
Store depletion induces Gαq‐mediated PLCβ1 activity to stimulate TRPC1 channels in vascular smooth muscle cells
The FASEB Journal·2015· 27 citedOpen Access
Myristoylated alanine‐rich C kinase substrate coordinates native TRPC1 channel activation by phosphatidylinositol 4,5‐bisphosphate and protein kinase C in vascular smooth muscle
The FASEB Journal·2013· 29 citedOpen Access
Differential effects of PI3K isoforms on TRPC channels in vascular smooth muscle: Novel actions of PI(3)P‐containing molecules
The FASEB Journal·2012
TRPC1 proteins confer PKC and phosphoinositol activation on native heteromeric TRPC1/C5 channels in vascular smooth muscle: comparative study of wild‐type and TRPC1 <sup>−/−</sup> mice
The FASEB Journal·2011· 54 citedOpen Access
<i>The Journal of Physiology</i> Annual Report 2010
The Journal of Physiology·2011Open Access
Inhibition of TRPC6 Channels by TRPC1/C5 Channel Activity Through a Ca2+ and Pkc-Dependent Mechanism
Biophysical Journal·2011Open Access
PI3 Kinase-Mediated Pathways Activate TRPC Channels in Vascular Myocytes
Biophysical Journal·2011Open Access
Activation Mechanisms and Molecular Properties of Cyclopiazonic Acid (CPA)-Evoked TRPC Channels in Vascular Myocytes from TRPC1-/- Mice
Biophysical Journal·2011Open Access
TRPC6 channels stimulated by angiotensin II are inhibited by TRPC1/C5 channel activity through a Ca<sup>2+</sup>- and PKC-dependent mechanism in native vascular myocytes
The Journal of Physiology·2010· 37 citedOpen Access
Ins(1,4,5)P<sub>3</sub> interacts with PIP<sub>2</sub> to regulate activation of TRPC6/C7 channels by diacylglycerol in native vascular myocytes
The Journal of Physiology·2010· 54 citedOpen Access
<i>The Journal of Physiology</i>Annual Report 2009
The Journal of Physiology·2010Open Access
Interactions between DAG, IP3 and PIP2 Govern Activation of Heterotetrameric TRPC6/C7 Channel Activity in Rabbit Portal Vein Myocytes
Biophysical Journal·2010Open Access
Activation of native TRPC1/C5/C6 channels by endothelin‐1 is mediated by both PIP<sub>3</sub>and PIP<sub>2</sub>in rabbit coronary artery myocytes
The Journal of Physiology·2009· 76 citedOpen Access
Obligatory role for phosphatidylinositol 4, 5‐bisphosphate (PIP2) in activating native TRPC store‐operated channels (SOCs) in vascular myocytes
The FASEB Journal·2009· 1 cited
Inositol 1,4,5‐trisphosphate (IP3) rescued TRPC channel activity from inhibition by phosphatidylinositol 4,5‐bisphosphate (PIP2) in vascular myocytes
The FASEB Journal·2009
Role of phosphoinositol 4,5-bisphosphate and diacylglycerol in regulating native TRPC channel proteins in vascular smooth muscle
Cell Calcium·2009· 81 cited
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Frequent Co-authors

Anthony P. Albert(18), Sohag Saleh(9), R. C. Hogg(6), Iain A. Greenwood(6), Q. Wang(5), N.G. Byrne(5), Q Wang(5), H P Rang(4), Claire M. Peppiatt‐Wildman(4), A. S. Piper(4), T. B. Bolton(3), R. M. Helliwell(3), Christopher D. Benham(2), Thierry Amédée(2), David N. Criddle(2), Roberto Soares de Moura(2), Min Ju(2), Jian Shi(2), Philippe Ascher(1), David Colquhoun(1)