Michael S. Kilberg

University of Florida — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

51h-index8.4kcitations140works0.02yr avg
OpenAlex↗ORCID↗Google Scholar↗Lab page↗

Accepting Students?

No reports yet. Know if this professor is taking students?

Research Topics

Amino Acid Enzymes and Metabolism(77), Metabolism and Genetic Disorders(47), Drug Transport and Resistance Mechanisms(22), RNA Research and Splicing(18), RNA and protein synthesis mechanisms(15)

Publications140 total

Utility of AlphaMissense predictions in Asparagine Synthetase deficiency variant classification
2023· 9 citedOpen Access
Metabolomic Profiling of Asparagine Deprivation in Asparagine Synthetase Deficiency Patient-Derived Cells
Nutrients·2023· 11 citedOpen Access
Characterizing asparagine synthetase deficiency variants in lymphoblastoid cell lines
JIMD Reports·2023· 10 citedOpen Access
A method for measurement of human asparagine synthetase (ASNS) activity and application to ASNS protein variants associated with ASNS deficiency
Biology Methods and Protocols·2023· 3 citedOpen Access
Analysis of Enzyme Activity and Cellular Function for the N80S and S480F Asparagine Synthetase Variants Expressed in a Child with Asparagine Synthetase Deficiency
International Journal of Molecular Sciences·2022· 4 citedOpen Access
Cellular and molecular characterization of two novel asparagine synthetase gene mutations linked to asparagine synthetase deficiency
Journal of Biological Chemistry·2022· 13 citedOpen Access
Sequencing of Argonaute-bound microRNA/mRNA hybrids reveals regulation of the unfolded protein response by microRNA-320a
PLoS Genetics·2021· 20 citedOpen Access
Myeloma Cells Deplete Bone Marrow Glutamine and Inhibit Osteoblast Differentiation Limiting Asparagine Availability
Cancers·2020· 38 citedOpen Access
PACT-mediated PKR activation acts as a hyperosmotic stress intensity sensor weakening osmoadaptation and enhancing inflammation
eLife·2020· 34 citedOpen Access
Author response: PACT-mediated PKR activation acts as a hyperosmotic stress intensity sensor weakening osmoadaptation and enhancing inflammation
2020· 1 citedOpen Access
Asparagine Synthetase in Cancer: Beyond Acute Lymphoblastic Leukemia
Frontiers in Oncology·2020· 161 citedOpen Access
Asparagine Synthetase Is Highly Expressed at Baseline in the Pancreas Through Heightened PERK Signaling
Cellular and Molecular Gastroenterology and Hepatology·2019· 18 citedOpen Access
Characterization of a novel variant in siblings with Asparagine Synthetase Deficiency
Molecular Genetics and Metabolism·2017· 31 citedOpen Access
Asparagine synthetase: Function, structure, and role in disease
Journal of Biological Chemistry·2017· 295 citedOpen Access
Increased Transcription of the Seryl‐tRNA Synthetase (SARS) Gene in Response to Amino Acid Limitation is Mediated by an Intronic C/EBP‐ATF Response Element (CARE) that Functions as an Distal Enhancer
The FASEB Journal·2017· 1 cited
The C/ebp-Atf response element (CARE) location reveals two distinct Atf4-dependent, elongation-mediated mechanisms for transcriptional induction of aminoacyl-tRNA synthetase genes in response to amino acid limitation
Nucleic Acids Research·2016· 40 citedOpen Access
Influence of Amino Acid Metabolism on Embryonic Stem Cell Function and Differentiation
Advances in Nutrition·2016· 54 citedOpen Access
Tumor suppressor BTG1 promotes PRMT1-mediated ATF4 function in response to cellular stress
Oncotarget·2015· 37 citedOpen Access
Asparagine Synthetase Deficiency causes reduced proliferation of cells under conditions of limited asparagine
Molecular Genetics and Metabolism·2015· 52 citedOpen Access
HIF1α Represses Cell Stress Pathways to Allow Proliferation of Hypoxic Fetal Cardiomyocytes
Developmental Cell·2015· 151 citedOpen Access
page 1 of 7Next →

Frequent Co-authors

Yuan‐Xiang Pan(7), Mary E. Handlogten(6), H N Christensen(5), Marc S. Malandro(5), Mark Beveridge(5), D. Novak(4), Ara M. Aslanian(4), Jixiu Shan(3), Richard G. Hutson(3), Stela S. Palii(3), Can Zhong(3), Nan Su(2), Van Leung‐Pineda(2), Nigel G. J. Richards(2), Balaji Tamarappoo(2), Robert T. Fremeau(2), Bradley S. Fletcher(2), Ellen F. Barber(2), Donald A. Novak(2), Alain Bruhat(2)