Hiroyuki Sakagami

Kitasato University — Japan

Biochemistry, Genetics and Molecular Biology · Life Sciences

42h-index6.2kcitations229works1.02yr avg
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Research Topics

Cellular transport and secretion(65), Neuroscience and Neuropharmacology Research(55), Protein Kinase Regulation and GTPase Signaling(27), Ion channel regulation and function(26), Calcium signaling and nucleotide metabolism(19)

Publications229 total

Characterization of Autonomous and Ca<sup>2<b>+</b></sup>/Calmodulin-Dependent Activities of CaMKK Isoforms In Vitro and in Mouse Tissues
Biochemistry·2025
EFA6A, a Guanine Nucleotide Exchange Factor for Arf6, Regulates Developmental Stage-Dependent Spine Morphogenesis, Synaptic Plasticity, and Long-Term Memory in the Hippocampus
Molecular Neurobiology·2025
Disruption of <i>Iqsec1</i> in mice leads to embryonic lethality with reduced large apical vacuoles in the visceral endoderm
FEBS Letters·2024
Author response for "Disruption of &lt;i&gt;Iqsec1&lt;/i&gt; in mice leads to embryonic lethality with reduced large apical vacuoles in the visceral endoderm"
2024
Localization of EFA6A, an exchange factor for Arf6, in Z-lines and sarcoplasmic reticulum membranes in addition to myofilaments in I-domains of skeletal myofibers of peri-natal mice
Acta Histochemica·2024· 1 cited
Temporal involvement of phosphatidylinositol 4‐phosphate 5‐kinase γ in differentiation of Z‐bands and myofilament bundles as well as intercalated discs in mouse heart at mid‐gestation
Journal of Anatomy·2024· 2 citedOpen Access
C-terminal truncations in IQSEC2: implications for synaptic localization, guanine nucleotide exchange factor activity, and neurological manifestations
Journal of Human Genetics·2024· 4 cited
Author response for "&lt;scp&gt;EFA6A&lt;/scp&gt;, an Exchange Factor for Arf6, Regulates &lt;scp&gt;NGF&lt;/scp&gt;‐Dependent &lt;scp&gt;TrkA&lt;/scp&gt; Recycling From Early Endosomes and Neurite Outgrowth in &lt;scp&gt;PC12&lt;/scp&gt; Cells"
2023
Transcriptional, biochemical, and immunohistochemical analyses of CaMKKβ/2 splice variants that co-localize with CaMKIV in spermatids
Cell Calcium·2023· 3 cited
Author response for "&lt;scp&gt;EFA6A&lt;/scp&gt;, an Exchange Factor for Arf6, Regulates &lt;scp&gt;NGF&lt;/scp&gt;‐Dependent &lt;scp&gt;TrkA&lt;/scp&gt; Recycling From Early Endosomes and Neurite Outgrowth in &lt;scp&gt;PC12&lt;/scp&gt; Cells"
2023
ADP Ribosylation Factor 4 (Arf4) Regulates Radial Migration through N-Cadherin Trafficking during Cerebral Cortical Development
eNeuro·2023· 4 citedOpen Access
Discrete localization patterns of <scp>PIP5Kγ</scp> and <scp>PLCβ3</scp> working sequentially in phosphoinositide‐cycle within mouse sensory neuron somata
Microscopy Research and Technique·2022· 1 cited
Molecular Mechanisms Underlying Ca2+/Calmodulin-Dependent Protein Kinase Kinase Signal Transduction
International Journal of Molecular Sciences·2022· 117 citedOpen Access
Localization of phosphatidylinositol phosphate 5 kinase γ, phospholipase β3 and diacylglycerol kinase ζ in corneal epithelium in comparison with conjunctival epithelium of mice
Experimental Eye Research·2022· 3 cited
Brain Dp140 alters glutamatergic transmission and social behaviour in the mdx52 mouse model of Duchenne muscular dystrophy
Progress in Neurobiology·2022· 40 citedOpen Access
Physiological and Pathological Roles of the Cytohesin Family in Neurons
International Journal of Molecular Sciences·2022· 9 citedOpen Access
Substrate recognition by Arg/Pro‐rich insert domain in calcium/calmodulin‐dependent protein kinase kinase for target protein kinases
FEBS Journal·2022· 7 cited
Author response for "Substrate recognition by Arg/Pro-rich insert domain in calcium/calmodulin-dependent protein kinase kinase for target protein kinases"
2022· 1 cited
Conformation-Dependent Reversible Interaction of Ca<sup>2+</sup>/Calmodulin-Dependent Protein Kinase Kinase with an Inhibitor, TIM-063
Biochemistry·2022· 3 cited
IQSEC3 Deletion Impairs Fear Memory Through Upregulation of Ribosomal S6K1 Signaling in the Hippocampus
Biological Psychiatry·2021· 10 cited
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Frequent Co-authors

Hisatake Kondo(26), Masahiro Fukaya(8), Kohji Fukunaga(8), Kazuki Nakao(5), Motoya Katsuki(5), Hideaki Tamaki(5), Masahiko Watanabe(5), Atsu Aiba(4), Yuji Owada(4), Kanako Hosono(4), Masataka Majima(4), Miyuki Nishi(4), Hiroshi Takeshima(4), Taisuke Miyazaki(4), Tatsuo Suzuki(4), Hiromu Yawo(3), Zhengui Xia(3), Toshiya Manabe(3), Yoshiya Ito(3), Tatsunori Suzuki(3)