Jun’ichi Kobayashi

Otsuka (Japan) — Japan

Biochemistry, Genetics and Molecular Biology · Life Sciences

59h-index13.0kcitations490works0.02yr avg
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Research Topics

Marine Sponges and Natural Products(333), Synthetic Organic Chemistry Methods(163), Synthesis and Biological Activity(137), Microbial Natural Products and Biosynthesis(99), Marine Toxins and Detection Methods(87)

Publications490 total

Effect of an Enteral Formula Enriched With ω-3 Fatty Acids, Carnitine, and Vitamin D on Body Weight, Heart Weight, and Blood Biochemical Parameters in a Dahl Rat Heart Failure Model
Journal of Cardiovascular Pharmacology·2024Open Access
Efficacy of KPR‐5714, a selective transient receptor potential melastatin 8 antagonist, on chronic psychological stress‐induced bladder overactivity in male rats
Neurourology and Urodynamics·2023Open Access
Zamamiphidins B and C, Manzamine-Related Alkaloids from an <i>Amphimedon</i> sp. Marine Sponge Collected in Okinawa
Journal of Natural Products·2022· 4 citedOpen Access
Ma'edamines E and F, rare bromotyrosine alkaloids possessing a 1,2,3,5-tetrasubstituted pyridinium moiety from an Okinawan marine sponge Suberea sp.
Tetrahedron Letters·2022· 6 cited
KPR‐5714, a selective transient receptor potential melastatin 8 antagonist, improves voiding dysfunction in rats with bladder overactivity but does not affect voiding behavior in normal rats
Neurourology and Urodynamics·2022· 4 cited
KPR-5714, a novel TRPM8 antagonist, improves frequent urination in a model with enhanced bladder afferent nerve activity
Proceedings for Annual Meeting of The Japanese Pharmacological Society·2022Open Access
Efficacy of the combination of KPR-5714, a novel transient receptor potential melastatin 8 (TRPM8) antagonist, and β3-adrenoceptor agonist or anticholinergic agent on bladder dysfunction in rats with bladder overactivity
European Journal of Pharmacology·2021· 13 cited
Identification of N-acyl-N-indanyl-α-phenylglycinamides as selective TRPM8 antagonists designed to mitigate the risk of adverse effects
Bioorganic & Medicinal Chemistry·2020· 7 citedOpen Access
Agesasines A and B, Bromopyrrole Alkaloids from Marine Sponges Agelas spp
Marine Drugs·2020· 15 citedOpen Access
KPR-5714, a Novel Transient Receptor Potential Melastatin 8 Antagonist, Improves Overactive Bladder via Inhibition of Bladder Afferent Hyperactivity in Rats
Journal of Pharmacology and Experimental Therapeutics·2020· 28 citedOpen Access
The manzamine alkaloids
˜The œAlkaloids. Chemistry and biology/˜The œalkaloids. Chemistry and biology·2020· 30 cited
Additional file 3 of Integrated omics unveil the secondary metabolic landscape of a basal dinoflagellate
Figshare·2020Open Access
Ma’edamines C and D, New Bromotyrosine Alkaloids Possessing a Unique Tetrasubstituted Pyridinium Moiety from an Okinawan Marine Sponge <i>Suberea</i> sp.
Organic Letters·2019· 18 cited
Ceratinadins E and F, New Bromotyrosine Alkaloids from an Okinawan Marine Sponge Pseudoceratina sp.
Marine Drugs·2018· 32 citedOpen Access
Ishigadine A, a new canthin-6-one alkaloid from an Okinawan marine sponge Hyrtios sp.
Tetrahedron Letters·2018· 9 cited
Symbiodinolactone A, a new 12-membered macrolide from symbiotic marine dinoflagellate Symbiodinium sp.
Tetrahedron Letters·2018· 4 cited
KPR‐2579, a novel TRPM8 antagonist, inhibits acetic acid‐induced bladder afferent hyperactivity in rats
Neurourology and Urodynamics·2018· 25 cited
Agelamasines A and B, diterpene alkaloids from an Okinawan marine sponge Agelas sp.
Journal of Natural Medicines·2017· 10 cited
Association of tongue brushing with the number of fungiform taste buds and taste perception: A preliminary study using confocal laser scanning microscopy in combination with a filter-paper disc method
Archives of Oral Biology·2017· 7 cited
New merosesquiterpenes from a Vietnamese marine sponge of Spongia sp. and their biological activities
Bioorganic & Medicinal Chemistry Letters·2017· 28 cited
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Frequent Co-authors

Yasushi Ohizumi(23), Hideshi Nakamura(16), Yoshimasa Hiratå(16), Masami Ishibashi(14), Takuma Sasaki(12), Masashi Tsuda(11), Hideyuki Shigemori(9), Jie‐Fei Cheng(5), Hou‐Ming Wu(5), Kenneth L. Rinehart(4), Takaaki Kubota(4), Markus Wälchli(4), Tomihisa Ohta(4), Gary C. Harbour(3), Jeremy Gilmore(3), Yuzuru Mikami(3), Takuma Sasaki(3), Tetsuya Murayama(3), Hiroshi Nakamura(3), Masaki Kobayashi(3)