Michèl R. Klein

Leiden University Medical Center — Netherlands

Medicine · Health Sciences

45h-index7.7kcitations102works0.02yr avg
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Research Topics

Tuberculosis Research and Epidemiology(32), HIV Research and Treatment(31), Immune Cell Function and Interaction(28), Mycobacterium research and diagnosis(23), T-cell and B-cell Immunology(12)

Publications102 total

T cell receptor repertoires associated with control and disease progression following Mycobacterium tuberculosis infection
Nature Medicine·2023· 92 citedOpen Access
RISK6, a 6-gene transcriptomic signature of TB disease risk, diagnosis and treatment response
Scientific Reports·2020· 157 citedOpen Access
Metabolite changes in blood predict the onset of tuberculosis
Nature Communications·2018· 154 citedOpen Access
Four-Gene Pan-African Blood Signature Predicts Progression to Tuberculosis
American Journal of Respiratory and Critical Care Medicine·2018· 261 citedOpen Access
Analysis of Host Responses to Mycobacterium tuberculosis Antigens in a Multi-Site Study of Subjects with Different TB and HIV Infection States in Sub-Saharan Africa
PLoS ONE·2013· 56 citedOpen Access
Correction: Potential of Host Markers Produced by Infection Phase-Dependent Antigen-Stimulated Cells for the Diagnosis of Tuberculosis in a Highly Endemic Area
PLoS ONE·2012· 6 citedOpen Access
Potential of Host Markers Produced by Infection Phase-Dependent Antigen-Stimulated Cells for the Diagnosis of Tuberculosis in a Highly Endemic Area
PLoS ONE·2012· 61 citedOpen Access
Potential of novel Mycobacterium tuberculosis infection phase-dependent antigens in the diagnosis of TB disease in a high burden setting
BMC Infectious Diseases·2012· 74 citedOpen Access
Knowledge Based DSS
IGI Global eBooks·2011
Genome-Based In Silico Identification of New <i>Mycobacterium tuberculosis</i> Antigens Activating Polyfunctional CD8+ T Cells in Human Tuberculosis
The Journal of Immunology·2010· 52 cited
Ag85B–ESAT-6 adjuvanted with IC31® promotes strong and long-lived Mycobacterium tuberculosis specific T cell responses in naïve human volunteers
Vaccine·2010· 201 cited
Mycobacterium tuberculosis Peptides Presented by HLA-E Molecules Are Targets for Human CD8+ T-Cells with Cytotoxic as well as Regulatory Activity
PLoS Pathogens·2010· 170 citedOpen Access
Cross-Reactive Immunity to <i>Mycobacterium tuberculosis</i> DosR Regulon-Encoded Antigens in Individuals Infected with Environmental, Nontuberculous Mycobacteria
Infection and Immunity·2009· 53 citedOpen Access
The DosR regulon of M. tuberculosis and antibacterial tolerance
Tuberculosis·2009· 71 cited
Immunogenicity of Novel DosR Regulon-Encoded Candidate Antigens of <i>Mycobacterium tuberculosis</i> in Three High-Burden Populations in Africa
Clinical and Vaccine Immunology·2009· 153 citedOpen Access
Analysis of Mycobacterium tuberculosis-Specific CD8 T-Cells in Patients with Active Tuberculosis and in Individuals with Latent Infection
PLoS ONE·2009· 94 citedOpen Access
Pulmonary delivery of DNA encoding Mycobacterium tuberculosis latency antigen Rv1733c associated to PLGA–PEI nanoparticles enhances T cell responses in a DNA prime/protein boost vaccination regimen in mice
Vaccine·2009· 115 cited
Evidence-Based Biosafety: a Review of the Principles and Effectiveness of Microbiological Containment Measures
Clinical Microbiology Reviews·2008· 139 citedOpen Access
<i>Mycobacterium bovis</i> BCG Vaccine Strains Lack <i>narK2</i> and <i>narX</i> Induction and Exhibit Altered Phenotypes during Dormancy
Infection and Immunity·2008· 40 citedOpen Access
Mycobacterial T Cell Responses in HIV‐Infected Patients with Advanced Immunosuppression
The Journal of Infectious Diseases·2008· 31 citedOpen Access
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Frequent Co-authors

Tom H. M. Ottenhoff(23), Kees L. M. C. Franken(17), Krista E. van Meijgaarden(15), Frank Miedema(13), Hazel M. Dockrell(11), Stefan H. E. Kaufmann(10), Gerhard Walzl(10), Shreemanta K. Parida(9), Annemieke Geluk(9), Gillian F. Black(8), Bonnie Thiel(7), Harriet Mayanja‐Kizza(7), W. Henry Boom(7), Willem A. Hanekom(7), Thomas J. Scriba(7), André G. Loxton(7), Novel N. Chegou(7), May Young Lin(6), Steven G. Smith(6), E. Jane Hughes(6)