Congxin Liang

nLIGHT (United States) — United States

Physics and Astronomy · Physical Sciences

23h-index2.6kcitations32works1.02yr avg
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Research Topics

Advanced Chemical Physics Studies(6), PI3K/AKT/mTOR signaling in cancer(4), Spectroscopy and Quantum Chemical Studies(4), Angiogenesis and VEGF in Cancer(3), Crystallography and molecular interactions(3)

Publications32 total

Phosphorylation of c-Myc at Ser62 via the protein kinase activity of acetaldehyde dehydrogenase 18A1 promotes tumor growth
Molecular Therapy·2025
Safety and efficacy of the selective tyrosine kinase 2/Janus kinase 1 inhibitor TLL-018 in moderate-to-severe plaque psoriasis: a phase Ib, randomized, double-blind, placebo-controlled study
British Journal of Dermatology·2025· 3 cited
Triptolide inhibits migration and viability, and promotes apoptosis by targeting the PI3K/Akt signaling pathway via upregulation of miR‑125a‑5p in SW1353 human chondrosarcoma cells
Molecular Medicine Reports·2025
PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments
Cancer Biology & Therapy·2010· 159 citedOpen Access
The Met kinase inhibitor SU11274 exhibits a selective inhibition pattern toward different receptor mutated variants
Oncogene·2004· 178 cited
Potent and selective inhibitors of the Met [hepatocyte growth factor/scatter factor (HGF/SF) receptor] tyrosine kinase block HGF/SF-induced tumor cell growth and invasion.
PubMed·2003· 114 cited
Structure-Based design and discovery of novel inhibitors of protein tyrosine phosphatases
Bioorganic & Medicinal Chemistry·2003· 56 cited
ChemInform Abstract: Rational Design of 4,5‐Disubstituted‐5,7‐dihydro‐pyrrolo[2,3‐d]pyrimidin‐6‐ones as a Novel Class of Inhibitors of Epidermal Growth Factor Receptor (EGF‐R) and Her2(p185<sup>erbB</sup>) Tyrosine Kinases.
ChemInform·2002· 1 cited
Rational design of 4,5-disubstituted-5,7-dihydro-pyrrolo[2,3-d]pyrimidin-6-ones as a novel class of inhibitors of epidermal growth factor receptor (EGF-R) and Her2(p185erbB) tyrosine kinases
Bioorganic & Medicinal Chemistry Letters·2002· 29 citedOpen Access
A novel cdk2-selective inhibitor, SU9516, induces apoptosis in colon carcinoma cells.
PubMed·2001· 146 cited
Indolinone tyrosine kinase inhibitors block Kit activation and growth of small cell lung cancer cells.
PubMed·2001· 98 cited
Inhibition Of Vascular Endothelial Growth Factor ( Vegf) And Stem- Cell Factor ( Scf) Receptor Kinases As Therapeutic Targets For The Treatment Of Human Diseases
2000
SU6668 is a potent antiangiogenic and antitumor agent that induces regression of established tumors.
PubMed·2000· 497 cited
Design, Synthesis, and Evaluations of Substituted 3-[(3- or 4-Carboxyethylpyrrol-2-yl)methylidenyl]indolin-2-ones as Inhibitors of VEGF, FGF, and PDGF Receptor Tyrosine Kinases
Journal of Medicinal Chemistry·1999· 271 citedOpen Access
Density functional study of model species for nucleic acids and lipids
Berichte der Bunsengesellschaft für physikalische Chemie·1997· 2 cited
Force field studies of cholesterol and cholesteryl acetate crystals and cholesterol–cholesterol intermolecular interactions
Journal of Computational Chemistry·1995· 22 cited
Ab initio studies of lipid model species. 2. Conformational analysis of inositols
Journal of the American Chemical Society·1994· 28 cited
The tetramer of borane and its heavier valence-isoelectronic analogs: M4H12 with M = B, Al, and Ga
Chemical Physics·1993· 18 cited
Ab initio studies of electron transfer. 2. Pathway analysis for homologous organic spacers
The Journal of Physical Chemistry·1993· 170 cited
Ab initio studies of lipid model species. 1. Dimethyl phosphate and methyl propyl phosphate anions
Journal of the American Chemical Society·1993· 65 cited
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Frequent Co-authors

Gerald McMahon(8), Henry F. Schaefer(7), Li Sun(6), Cho Tang(5), Kenneth E. Lipson(5), Leland C. Allen(5), Audie Rice(3), Carl S. Ewig(3), Terry R. Stouch(3), A. T. Hagler(3), James Cheng‐Chung Wei(3), Laura K. Shawver(2), Robert A. Blake(2), Flora Tang(2), Marshall D. Newton(2), Anthony R. Howlett(2), David Kiewlich(2), Stefan Vasile(2), Jean Cui(2), Yong Zhou(2)