Paul F. Worley

University of Arizona — United States

Neuroscience · Life Sciences

20h-index5.0kcitations37works2.32yr avg
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Research Topics

Ion Channels and Receptors(22), Phytochemicals and Antioxidant Activities(6), Neurobiology and Insect Physiology Research(6), Ion channel regulation and function(4), Neuroinflammation and Neurodegeneration Mechanisms(4)

Publications36 total

Transcriptomic profiling of the middle temporal gyrus reveals differential glial/neuronal dysregulation across Alzheimer’s disease and aging
2025Open Access
Transcriptomic and protein analysis of human cortex reveals genes and pathways linked to NPTX2 disruption in Alzheimer’s disease
2025Open Access
CSF Levels of NPTX2 Are Associated With Less Brain Atrophy Over Time in Cognitively Unimpaired Individuals
Annals of Clinical and Translational Neurology·2025· 1 citedOpen Access
Cognitive resilience in preclinical Alzheimer’s disease: Higher NPTX2 and VGF levels are associated with reduced cognitive decline
Neurobiology of Aging·2025· 3 citedOpen Access
CSF Levels of NPTX2 are Associated With Decreased Rate of Brain Atrophy Over Time in Cognitively Unimpaired Individuals (P7-3.014)
Neurology·2025
Cognitive Resilience in Preclinical Alzheimer's Disease: Higher Nptx2 and Vgf Levels are Associated with Reduced Cognitive Decline
SSRN Electronic Journal·2025· 1 citedOpen Access
The synaptic marker NPTX2 and longitudinal brain atrophy among cognitively unimpaired adults
Alzheimer s & Dementia·2024Open Access
The calcium channel Orai1 is required for osteoblast development: Studies in a chimeric mouse with variable in vivo Runx-cre deletion of Orai-1
PLoS ONE·2023· 4 citedOpen Access
Orai1 channels in platelets contribute to Ca2+ entry and aggregation evoked by depletion of IP3- and NAADP-sensitive Ca2+ stores
Journal of Molecular and Cellular Cardiology·2022
Reduction in SOCE and Associated Aggregation in Platelets from Mice with Platelet-Specific Deletion of Orai1
Cells·2022· 7 citedOpen Access
Neuronal pentraxin 2 is required for facilitating excitatory synaptic inputs onto spinal neurons involved in pruriceptive transmission in a model of chronic itch
Nature Communications·2022· 19 citedOpen Access
The calcium channel Orai1 is required for osteoblast development: studies in a chimeric mouse with variable <i>in vivo</i> Runx-cre deletion of Orai-1
2022Open Access
Resolving macrophage polarization through distinct Ca2+ entry channel that maintains intracellular signaling and mitochondrial bioenergetics
iScience·2021· 43 citedOpen Access
Cardiomyocyte-Specific Deletion of Orai1 Reveals Its Protective Role in Angiotensin-II-Induced Pathological Cardiac Remodeling
Cells·2020· 19 citedOpen Access
FRMPD4 mutations cause X-linked intellectual disability and disrupt dendritic spine morphogenesis
Human Molecular Genetics·2017· 34 citedOpen Access
Orai1-Mediated Antimicrobial Secretion from Pancreatic Acini Shapes the Gut Microbiome and Regulates Gut Innate Immunity
Cell Metabolism·2017· 185 citedOpen Access
RETRACTED: Enhanced Polyubiquitination of Shank3 and NMDA Receptor in a Mouse Model of Autism
Cell·2011· 115 citedOpen Access
STIM1-dependent and STIM1-independent Function of Transient Receptor Potential Canonical (TRPC) Channels Tunes Their Store-operated Mode
Journal of Biological Chemistry·2010· 77 citedOpen Access
An endoplasmic reticulum/plasma membrane junction: STIM1/Orai1/TRPCs
FEBS Letters·2009· 138 cited
Molecular determinants of fast Ca <sup>2+</sup> -dependent inactivation and gating of the Orai channels
Proceedings of the National Academy of Sciences·2009· 132 citedOpen Access
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Frequent Co-authors

Shmuel Muallem(15), Joseph P. Yuan(14), Weizhong Zeng(8), Guo N. Huang(5), Corinne Pettigrew(5), Abhay Moghekar(5), Chan Hyun Na(5), Anja Soldan(5), Joo Young Kim(4), Kirill Kiselyov(4), Dong Min Shin(4), Marlin H. Dehoff(4), Sungtaek Oh(4), Min Seuk Kim(3), Kyu Pil Lee(3), Insuk So(3), Marc Freichel(3), Juan E. Camacho Londoño(3), Claire Anderson(3), Juan P. Vazquez(3)