C J Homcy

Biochemistry, Genetics and Molecular Biology · Life Sciences

46h-index7.1kcitations133works0.02yr avg
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Research Topics

Receptor Mechanisms and Signaling(63), Neuropeptides and Animal Physiology(23), Pharmacological Effects and Assays(21), Heart Failure Treatment and Management(11), Cardiac electrophysiology and arrhythmias(10)

Publications133 total

β-Adrenergic Receptor Regulation in Cardiac Disease
2020· 1 cited
Metal Coordination-Based Inhibitors of Adenylyl Cyclase:  Novel Potent P-Site Antagonists
Journal of Medicinal Chemistry·2003· 23 citedOpen Access
Accelerated Cardiomyopathy in Mice With Overexpression of Cardiac G <sub>s</sub> α and a Missense Mutation in the α-Myosin Heavy Chain
Circulation·2002· 29 citedOpen Access
Type-specific Regulation of Adenylyl Cyclase
Journal of Biological Chemistry·2001· 113 citedOpen Access
Development of type V adenylyl cyclase-targeted drugs
2001
Determinants of the Cardiomyopathic Phenotype in Chimeric Mice Overexpressing Cardiac Gsα
Circulation Research·2000· 31 citedOpen Access
β-Adrenergic Receptor Signaling: An Acute Compensatory Adjustment—Inappropriate for the Chronic Stress of Heart Failure?
Circulation Research·2000· 53 citedOpen Access
β-Adrenergic receptor blockade arrests myocyte damage and preserves cardiac function in the transgenic Gsα mouse
Journal of Clinical Investigation·1999· 120 citedOpen Access
Beta-adrenergic receptor– G protein–adenylyl cyclase signal transduction in the failing heart
The American Journal of Cardiology·1999· 57 cited
Differential regulation of inotropy and lusitropy in overexpressed Gsα myocytes through cAMP and Ca2+ channel pathways
Journal of Clinical Investigation·1999· 32 citedOpen Access
Apoptosis of Cardiac Myocytes in Gsα Transgenic Mice
Circulation Research·1999· 170 cited
Cardiac G <sub>sα</sub> overexpression enhances L-type calcium channels through an adenylyl cyclase independent pathway
Proceedings of the National Academy of Sciences·1998· 60 citedOpen Access
Comparative efficacy of intravenous eptifibatide, a potent and reversible platelet GP IIb/IIIa receptor antagonist, versus recombinant tissue plasminogen activator for coronary thrombolysis in a canine model
1998· 1 cited
Signaling Hypertrophy
Circulation·1998· 34 citedOpen Access
Overexpression of myocardial Gsalpha prevents full expression of catecholamine desensitization despite increased beta-adrenergic receptor kinase.
Journal of Clinical Investigation·1998· 44 citedOpen Access
Depressed Heart Rate Variability and Arterial Baroreflex in Conscious Transgenic Mice With Overexpression of Cardiac G <sub>sα</sub>
Circulation Research·1998· 152 citedOpen Access
Localisation of Cardiac GSαin Transgenic Mice Overexpressing GSα
Journal of Molecular and Cellular Cardiology·1997· 5 cited
The Adenylyl Cyclases as Integrators of Transmembrane Signal Transduction
Circulation Research·1997· 162 cited
Conformation-dependent activation of type II adenylyl cyclase by protein kinase C
Journal of Cellular Biochemistry·1997· 11 cited
Cardiomyopathy induced by cardiac Gs alpha overexpression
American Journal of Physiology-Heart and Circulatory Physiology·1997· 162 cited
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Frequent Co-authors

Dorothy E. Vatner(22), Stephen F. Vatner(19), Yoshihiro Ishikawa(16), Richard P. Shannon(8), Thomas E. Wagner(7), Robert M. Graham(5), Kuniya Asai(5), Mitsunori Iwase(4), Jun-ichi Kawabe(4), Sanford P. Bishop(3), Masami Uechi(3), David C. Wight(3), Shuichi Katsushika(3), Stephen M. Lanier(3), John T. Fallon(3), E Haber(3), Stanley G. Rockson(3), W T Manders(3), S. F. Vatner(3), Wei Cheng(2)