Frank Speleman

Ghent University Hospital — Belgium

Medicine · Health Sciences

36h-index24.4kcitations118works1.02yr avg
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Research Topics

Neuroblastoma Research and Treatments(41), Acute Lymphoblastic Leukemia research(14), Genomic variations and chromosomal abnormalities(13), Cancer, Hypoxia, and Metabolism(10), Virus-based gene therapy research(8)

Publications115 total

Synergistic inhibition of CHK1 and MUS81 to combat replication stress resistance in high-risk neuroblastoma
Scientific Reports·2025Open Access
AURKA promotes malignant properties of neuroblastoma and is downregulated by the PP2A pathway
2025Open Access
Accelerating Drug Development for Neuroblastoma: Consensus Statement From the Third Neuroblastoma Drug Development Strategy Forum
Pediatric Blood & Cancer·2025· 3 citedOpen Access
Whole transcriptome profiling of liquid biopsies from tumour xenografted mouse models enables specific monitoring of tumour-derived extracellular RNA
NAR Cancer·2022· 10 citedOpen Access
Abstract 1670: A human pluripotent stem cell derived differentiation model for the study of normal and transformed sympatho-adrenal progenitors
Cancer Research·2022
RRM2 is a target for synthetic lethal interactions with replication stress checkpoint addiction in high-risk neuroblastoma
2020· 5 citedOpen Access
Purification of high-quality RNA from a small number of fluorescence activated cell sorted zebrafish cells for RNA sequencing purposes
BMC Genomics·2019· 13 citedOpen Access
A comprehensive inventory of TLX1 controlled long non-coding RNAs in T-cell acute lymphoblastic leukemia through polyA+ and total RNA sequencing
Haematologica·2018· 25 citedOpen Access
Cell of origin dictates aggression and stem cell number in acute lymphoblastic leukemia
Leukemia·2018· 26 citedOpen Access
Promoter-associated proteins of EPAS1 identified by enChIP-MS – A putative role of HDX as a negative regulator
Biochemical and Biophysical Research Communications·2018· 14 cited
Genomic Amplifications and Distal 6q Loss: Novel Markers for Poor Survival in High-risk Neuroblastoma Patients
JNCI Journal of the National Cancer Institute·2018· 92 citedOpen Access
Shallow Whole Genome Sequencing on Circulating Cell-Free DNA Allows Reliable Noninvasive Copy-Number Profiling in Neuroblastoma Patients
Clinical Cancer Research·2017· 119 cited
Dual targeting of MDM2 and BCL2 as a therapeutic strategy in neuroblastoma
Oncotarget·2017· 33 citedOpen Access
Abstract 5815: The HBP1 tumor suppressor is a negative epigenetic regulator of MYCN driven neuroblastoma through interaction with the PRC2 complex
Cancer Research·2017
Abstract 5506: SOX11 acts as part of the MYCN-WEE1 regulatory protein complex implicated in neuroblastoma
Cancer Research·2017· 1 cited
RPPA-Based Protein Profiling Reveals Enhanced PI3K/AKT/mTOR Signaling in ETV6/RUNX1-Positive Acute Lymphoblastic Leukemia Patients with Low CD200 Expression
Blood·2016· 1 cited
Impact of Age and Treatment Group in Childhood High Hyperdiploid Low Risk B-Cell Acute Lymphoblastic Leukemia (ALL): Results of the CLG-EORTC 58951 Study
Blood·2016
Unique Long Non-Coding RNA Expression Signature in ETV6/RUNX1-Driven B-Cell Precursor Acute Lymphoblastic Leukemia
Blood·2016· 1 cited
Targeting tachykinin receptors in neuroblastoma
Oncotarget·2016· 28 citedOpen Access
Novel biological insights in T-cell acute lymphoblastic leukemia
Experimental Hematology·2015· 106 citedOpen Access
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Frequent Co-authors

Jo Vandesompele(17), Nadine Van Roy(15), Katleen De Preter(13), Geneviève Laureys(11), Yves Benoît(10), Pieter Van Vlierberghe(9), Alexander Schramm(8), Angelika Eggert(8), Anne De Paepe(7), Bruce Poppe(6), Tim Lammens(6), Björn Menten(6), Johannes H. Schulte(6), Tom Taghon(5), Joni Van der Meulen(5), Filip Matthijssens(4), Barbara De Moerloose(4), Kaat Durinck(4), Pieter Rondou(4), Rogier Versteeg(4)