John Hines

University College Hospital at Westmoreland Street — United Kingdom

Biochemistry, Genetics and Molecular Biology · Life Sciences

27h-index6.0kcitations57works17.82yr avg
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Research Topics

Protein Degradation and Inhibitors(25), Ubiquitin and proteasome pathways(21), Multiple Myeloma Research and Treatments(12), Peptidase Inhibition and Analysis(6), Marine Sponges and Natural Products(5)

Publications57 total

Bidirectional Crosstalk Between Bladder Cancer Cells and Normal Fibroblasts Drives Phenotypic Reprogramming and Modulates Chemosensitivity
2025Open Access
Regulated induced proximity targeting chimeras—RIPTACs—A heterobifunctional small molecule strategy for cancer selective therapies
Cell chemical biology·2024· 52 citedOpen Access
EGFR targeting PhosTACs as a dual inhibitory approach reveals differential downstream signaling
Science Advances·2024· 31 citedOpen Access
Development of a Small Molecule Downmodulator for the Transcription Factor Brachyury
Angewandte Chemie·2024· 1 cited
Development of a Small Molecule Downmodulator for the Transcription Factor Brachyury
Angewandte Chemie International Edition·2024· 5 citedOpen Access
Targeted Dephosphorylation of Tau by Phosphorylation Targeting Chimeras (PhosTACs) as a Therapeutic Modality
Journal of the American Chemical Society·2023· 72 citedOpen Access
Regulated Induced Proximity Targeting Chimeras (RIPTACs): a Novel Heterobifunctional Small Molecule Therapeutic Strategy for Killing Cancer Cells Selectively
2023· 33 citedOpen Access
Hijacking Methyl Reader Proteins for Nuclear-Specific Protein Degradation
Journal of the American Chemical Society·2022· 33 citedOpen Access
Hijacking Methyl Reader Proteins for Nuclear-Specific Protein Degradation
2022Open Access
Mutant-selective degradation by BRAF-targeting PROTACs
Nature Communications·2021· 131 citedOpen Access
Peer Review #1 of "Expression of the neurotrophic tyrosine kinase receptors, ntrk1 and ntrk2a, precedes expression of other ntrk genes in embryonic zebrafish (v0.2)"
2020Open Access
Peer Review #1 of "Expression of the neurotrophic tyrosine kinase receptors, ntrk1 and ntrk2a, precedes expression of other ntrk genes in embryonic zebrafish (v0.1)"
2020Open Access
Mutant-selective Degradation by BRAF-targeting PROTACs
2020· 14 citedOpen Access
Design, synthesis and biological evaluation of Proteolysis Targeting Chimeras (PROTACs) as a BTK degraders with improved pharmacokinetic properties
Bioorganic & Medicinal Chemistry Letters·2019· 87 citedOpen Access
Addressing Kinase-Independent Functions of Fak via PROTAC-Mediated Degradation
Journal of the American Chemical Society·2018· 276 cited
Enhancing Antiproliferative Activity and Selectivity of a FLT-3 Inhibitor by Proteolysis Targeting Chimera Conversion
Journal of the American Chemical Society·2018· 168 cited
MDM2-Recruiting PROTAC Offers Superior, Synergistic Antiproliferative Activity via Simultaneous Degradation of BRD4 and Stabilization of p53
Cancer Research·2018· 326 cited
Lessons in PROTAC Design from Selective Degradation with a Promiscuous Warhead
Cell chemical biology·2017· 871 citedOpen Access
The Advantages of Targeted Protein Degradation Over Inhibition: An RTK Case Study
Cell chemical biology·2017· 643 citedOpen Access
Modular PROTAC Design for the Degradation of Oncogenic BCR‐ABL
Angewandte Chemie International Edition·2015· 607 citedOpen Access
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Frequent Co-authors

Craig M. Crews(35), Saul Jaime‐Figueroa(9), Kanak Raina(5), Yimin Qian(4), Hanqing Dong(4), Jing Wang(4), Momar Toure(4), Hyun Seop Tae(4), Andrew P. Crew(3), George M. Burslem(3), Ashton C. Lai(3), Dennis L. Buckley(3), Jeffrey L. Gustafson(3), Kusal T. G. Samarasinghe(3), John S. Schneekloth(3), J.R. Lott(3), Jing Lü(2), Martha Altieri(2), Kevin Coleman(2), Daniel P. Bondeson(2)