Armin Giese

General Motors (Germany) — Germany

Medicine · Health Sciences

4h-index180citations14works4.02yr avg
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Research Topics

Parkinson's Disease Mechanisms and Treatments(5), Alzheimer's disease research and treatments(5), Medical Imaging Techniques and Applications(3), Neurological disorders and treatments(3), Genetic Neurodegenerative Diseases(2)

Publications14 total

[11C]MODAG 005 – a PET tracer targeting alpha-synuclein aggregates in the brain
2025Open Access
Anle138b binds predominantly to the central cavity in lipidic Aβ₄₀ fibrils and modulates fibril formation
Nature Communications·2025· 1 citedOpen Access
Co-occurrence of multiple pathologies in a case of frontotemporal dementia with TBK1 mutation: first in vivo detection of alpha-synuclein and tau co-pathology.
PubMed·2025Open Access
The clinical drug candidate anle138b binds predominantly to the central cavity in lipidic Aβ₄₀ fibrils and modulates fibril formation
2025Open Access
Alpha‐synuclein co‐pathology in Down syndrome‐associated Alzheimer's disease
Alzheimer s & Dementia·2025· 3 citedOpen Access
Structural insight into binding of novel PET tracer MODAG-005 to lipidic <i>α</i> -Synuclein fibrils
2025Open Access
A quantitative Lewy-fold-specific alpha-synuclein seed amplification assay as a progression marker for Parkinson’s disease
Acta Neuropathologica·2025· 25 citedOpen Access
The amyloid oligomer modulator anle138b has disease modifying effects in a human IAPP transgenic mouse model of type 2 diabetes mellitus (hIAPP Ob/Ob mice)
2024· 1 citedOpen Access
[11C]MODAG 005 – a novel PET tracer targeting alpha-synuclein aggregates in the brain
2024· 6 citedOpen Access
Development and Radiosynthesis of [11C]MODAG-005 for in vivo Imaging of alpha-synuclein Pathology
Nuclear Medicine and Biology·2023· 1 cited
[C-11]MODAG-001-towards a PET tracer targeting alpha-synuclein aggregates
European Journal of Nuclear Medicine and Molecular Imaging·2021· 3 cited
[11C]MODAG-001—towards a PET tracer targeting α-synuclein aggregates
European Journal of Nuclear Medicine and Molecular Imaging·2020· 90 citedOpen Access
<sup>11</sup>C Radiolabeling of anle253b: a Putative PET Tracer for Parkinson's Disease That Binds to α‐Synuclein Fibrils in vitro and Crosses the Blood‐Brain Barrier
ChemMedChem·2019· 50 citedOpen Access
Multivariate MRI atlas of Basal Ganglia for comparative studies and treatment planning in neurodegenerative movement disorders
Basal Ganglia·2017

Frequent Co-authors

Andrei Leonov(10), Sergey Ryazanov(10), Christian Griesinger(10), Kristina Herfert(7), Laura Kuebler(6), Sabrina Buss(6), Andreas Maurer(6), Daniel Bleher(6), Felix Schmidt(5), Bernd J. Pichler(5), Viktoria Ruf(5), Johannes Levin(5), Daniel Weckbecker(4), Ran Sing Saw(4), Alexander Bernhardt(3), Sebastian Longen(3), Svenja V. Trossbach(3), Federica Bonanno(3), Ann-Kathrin Grotegerd(3), Bernadette Dahl(3)