Jielin Xu

Cleveland Clinic — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

16h-index1.2kcitations71works4.02yr avg
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Research Topics

Bioinformatics and Genomic Networks(24), Neuroinflammation and Neurodegeneration Mechanisms(22), Alzheimer's disease research and treatments(12), Single-cell and spatial transcriptomics(11), Long-Term Effects of COVID-19(9)

Publications71 total

Combining xQTL and genome-wide association studies from diverse populations improves druggable gene discovery
Nature Communications·2026Open Access
The Alzheimer's Cell Atlas: A comprehensive brain single‐cell transcriptomic atlas using a generative AI foundation model
Alzheimer s & Dementia·2025Open Access
Single‐cell transcriptomics analysis identifies oligodendrocyte‐microglia crosstalk modulated by TREM2‐R47H and exacerbated by APOE4 in Alzheimer's disease
Alzheimer s & Dementia·2025Open Access
Combining xQTL and genome‐wide association studies from ethnically diverse populations improves druggable gene discovery
Alzheimer s & Dementia·2025Open Access
Abstract 4367051: A novel deep learning framework identified associated genes and Interpretable deep learning translation of GWAS findings for drug repurposing in Atrial Fibrillation
Circulation·2025
Dysregulation of innate immunity and cellular metabolism through virus-induced deISGylation
2025· 1 citedOpen Access
A Scalable Human Brain Cell Atlas Foundation Model Dissects the Cellular Immune Codes and Cognitive Resilience
2025Open Access
Combining xQTL and genome-wide association studies from ethnically diverse populations improves druggable gene discovery
2025Open Access
The condensed-state structure and evolution mechanism of Poly(butylene-succinate) (PBS) multi-filaments in the complex stress and thermal fields of the melt-spinning process
Polymer·2025· 1 cited
CE-499645-002 SODIUM-GLUCOSE COTRANSPORTER2 INHIBITORS AND GLUCAGON-LIKE PEPTIDE 1 RECEPTOR AGONISTS: ASSOCIATION WITH ATRIAL FIBRILLATION INCIDENCE AND MECHANISTIC INSIGHTS
Heart Rhythm·2025
Genomic and epigenomic insights into purkinje and granule neurons in Alzheimer’s disease and related dementia using single-nucleus multiome analysis
2025· 3 citedOpen Access
A network-based systems genetics framework identifies pathobiology and drug repurposing in Parkinson’s disease
npj Parkinson s Disease·2025· 5 citedOpen Access
Combining genetics with real-world patient data enables ancestry-specific target identification and drug discovery in Alzheimer’s disease
2025· 1 citedOpen Access
The Condensed-State Structure and Evolution Mechanism of Poly(Butylene-Succinate) (Pbs) Multi-Filaments in the Complex Stress and Thermal Fields of the Melt - Spinning Process
SSRN Electronic Journal·2025Open Access
Combining xQTL and Genome-Wide Association Studies from Ethnically Diverse Populations Improves Druggable Gene Discovery
SSRN Electronic Journal·2025· 1 citedOpen Access
Single‐microglia transcriptomic transition network‐based prediction and real‐world patient data validation identifies ketorolac as a repurposable drug for Alzheimer's disease
Alzheimer s & Dementia·2024· 10 citedOpen Access
snRNA‐seq analysis of human brains suggests cell type‐specific synergistic effects of APOE4 and TREM2‐R47H and potential drug targets in Alzheimer’s Disease
Alzheimer s & Dementia·2024· 1 citedOpen Access
Cross‐species protein interactome network‐based analysis of GWAS and human brain quantitative trait loci (x‐QTL) data identifies risk genes and drug targets for Alzheimer’s disease
Alzheimer s & Dementia·2024Open Access
Single‐Microglia Transcriptomic Transition Network‐based Prediction and Real‐world Patient Data Validation Identifies Ketorolac as a Repurposable Drug for Alzheimer’s Disease
Alzheimer s & Dementia·2024Open Access
A deep learning‐based deconvolution framework identifies human brain cell‐type specific expression quantitative trait loci (eQTLs) and pathobiology in Alzheimer’s disease
Alzheimer s & Dementia·2024Open Access
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Frequent Co-authors

Feixiong Cheng(34), Andrew A. Pieper(22), James B. Leverenz(19), Yadi Zhou(14), Jeffrey L. Cummings(14), Yuan Hou(10), Yuan Hou(8), Lynn M. Bekris(7), Fuhai Li(5), Yunlong Liu(4), Haiyuan Yu(4), Lang Li(4), Chang Su(4), Zhenxing Xu(4), Wenqiang Song(4), Lijun Dou(4), William R. Martin(4), Asha Kallianpur(3), Reena Mehra(3), Lara Jehi(3)