John Byon

ARC Centre of Excellence in Synthetic Biology — Australia

Biochemistry, Genetics and Molecular Biology · Life Sciences

13h-index738citations26works0.82yr avg
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Research Topics

Protein Tyrosine Phosphatases(6), MicroRNA in disease regulation(4), Virus-based gene therapy research(4), Acute Myeloid Leukemia Research(3), Immunotherapy and Immune Responses(3)

Publications26 total

Azer-cel, an allogeneic (allo) CD19 CAR T, in combination with low-dose interleukin-2 (IL-2) demonstrates clinical activity in patients with large B-cell lymphoma (LBCL) who relapsed after autologous (auto) CAR T
Blood·2025Open Access
Administration of Low-Dose, Subcutaneous (SC) Interleukin-2 (IL-2) Markedly Enhances the Pharmacokinetic (PK) Profile of Azercabtagene Zapreleucel (azer-cel), an Allogeneic Anti-CD19 Chimeric Antigen Receptor (CAR) T-Cell Therapy, without Compromising Safety and Early Evidence of Clinical Activity in Patients with Diffuse Large B-Cell Lymphoma (DLBCL) Who Have Relapsed after Prior CD19-Directed CAR T-Cell Products
Transplantation and Cellular Therapy·2025
Combination therapy with the oncolytic virus CF33-CD19 and blinatumomab for the treatment of advanced solid tumors.
Journal of Clinical Oncology·2024· 3 cited
Abstract CT182: Oncolytic virus CF33-hNIS for the treatment of advanced cancer
Cancer Research·2024
Oncolytic virus CF33-hNIS monotherapy for the treatment of gastrointestinal (GI) malignancies.
Journal of Clinical Oncology·2024· 1 cited
JCARH125, Anti-BCMA CAR T-cell Therapy for Relapsed/Refractory Multiple Myeloma: Initial Proof of Concept Results from a Phase 1/2 Multicenter Study (EVOLVE)
Blood·2018· 124 cited
Evidence of Targetable Immune Dysfunction in the Bone Marrow of Patients with Intermediate/High-Risk Myelodysplastic Syndrome Refractory to Hypomethylating Agents
Blood·2017· 1 cited
Tigit, CD226 and PD-L1/PD-1 Are Highly Expressed By Marrow-Infiltrating T Cells in Patients with Multiple Myeloma
Blood·2016· 17 cited
Distinct Patterns of PD-L1 and PD-L2 Expression By Tumor and Non-Tumor Cells in Patients with MM, MDS and AML
Blood·2016· 13 cited
Safety and Clinical Activity of Atezolizumab (Anti-PDL1) in Combination with Obinutuzumab in Patients with Relapsed or Refractory Non-Hodgkin Lymphoma
Blood·2015· 19 cited
The KDM2B- Let-7b -EZH2 Axis in Myelodysplastic Syndromes as a Target for Combined Epigenetic Therapy
PLoS ONE·2014· 32 citedOpen Access
Deletion of Dicer in late erythroid cells results in impaired stress erythropoiesis in mice
Experimental Hematology·2014· 12 citedOpen Access
The Jumanjii Histone Demethylase KDM2B controls EZH2 Expression In Myelodysplastic Syndromes (MDS) Via Mir Let-7b (let7b), a Pathway That Is Bypassed By The Histone Methylation Inhibitor DZNep
Blood·2013
FLVCR is necessary for erythroid maturation, may contribute to platelet maturation, but is dispensable for normal hematopoietic stem cell function
Blood·2013· 17 citedOpen Access
Transcriptional regulation of miR-10a/b by TWIST-1 in myelodysplastic syndromes
Haematologica·2012· 50 citedOpen Access
Why Do Erythroid Cells Need to Export Heme?
Blood·2011
FLVCR Deletion Does Not Impact Normal Hematopoietic Stem Cell Function but Is Necessary for Erythroid and T-Cell Maturation and Enhances Platelet Formation
Blood·2011
MicroRNAs: Allies or Foes in erythropoiesis?
Journal of Cellular Physiology·2011· 34 citedOpen Access
The Emerging Role of Prostaglandin E2 in Regulating Stem Cell Function
The Hematologist·2009
Insulin regulates MAP kinase phosphatase-1 induction in Hirc B cells via activation of both extracellular signal-regulated kinase (ERK) and c-Jun-N-terminal kinase (JNK)
Molecular and Cellular Biochemistry·2001· 15 cited
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Frequent Co-authors

Anasua B. Kusari(6), Jyotirmoy Kusari(6), Jeffrey M. Venstrom(4), Sharon Yavrom(4), H. Joachim Deeg(3), A. Mario Marcondes(3), Paul Woodard(3), Connie Ma(3), Alberto Robert(3), Joanne I. Adamkewicz(3), Raymond T. Doty(3), Janis L. Abkowitz(3), Daneng Li(3), Amanda Seiz(3), Grey Wilkinson(3), Kathleen A. Kenner(2), Thalia Papayannopoulou(2), Ekapun Karoopongse(2), Cecilia C.S. Yeung(2), Joseph Woodard(2)