Jon M. Askham

University of Leeds — United Kingdom

Biochemistry, Genetics and Molecular Biology · Life Sciences

16h-index1.1kcitations29works0.02yr avg
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Research Topics

Microtubule and mitosis dynamics(11), Wnt/β-catenin signaling in development and cancer(7), Ubiquitin and proteasome pathways(6), Cancer-related Molecular Pathways(4), DNA Repair Mechanisms(3)

Publications29 total

201 RESTORING AKT ACTIVITY IN LATE OUTGROWTH ENDOTHELIAL PROGENITOR CELLS FROM HUMANS AT HIGH CARDIOVASCULAR RISK RESCUES THEIR ANGIOGENIC CAPACITY
Heart·2013Open Access
A Novel p53 Mutant Found in Iatrogenic Urothelial Cancers Is Dysfunctional and Can Be Rescued by a Second-site Global Suppressor Mutation
Journal of Biological Chemistry·2013· 11 citedOpen Access
Restoring Akt1 activity in endothelial progenitors from insulin resistant humans rescues vascular reparative capacity
Proceedings of The Physiological Society·2013
A Gene-based restoration of Akt activity in endothelial progenitor cells from human subjects at high cardiovascular risk rescues vascular reparative capacity
Heart·2012· 1 citedOpen Access
Abstract LB-152: PIK3CA mutation spectrum in urothelial carcinoma reflects cell context-dependent signalling and phenotypic outputs
Cancer Research·2012
PIK3CA mutation spectrum in urothelial carcinoma reflects cell context-dependent signaling and phenotypic outputs
Oncogene·2012· 40 cited
EB1 Is Required for Spindle Symmetry in Mammalian Mitosis
PLoS ONE·2011· 21 citedOpen Access
() Immunoblot showing levels of wild-type and mutant TSC1-FLAG proteins and endogenous TSC2 in 97-1 cell lines
Figshare·2011Open Access
() Immunoblot showing TSC1 and TSC2 in 97-1 Neo control and FLAG-tagged wild-type and mutant TSC1 cell line lysates immunoprecipitated with anti-TSC1 and non-specific mouse IgM antibodies
Figshare·2011Open Access
Semi quantitative RT–PCR analysis of TSC1 RNA in normal urothelial cells and mutant tumour samples, showing increased electrophoretic mobility of RT–PCR products amplified from cDNA from tumours containing 104CG () and 314AG () missense mutations
Figshare·2011Open Access
How to become immortal: let MEFs count the ways
Aging·2010· 45 citedOpen Access
AKT1 mutations in bladder cancer: identification of a novel oncogenic mutation that can co-operate with E17K
Oncogene·2009· 107 cited
Bladder tumour-derived somatic TSC1 missense mutations cause loss of function via distinct mechanisms
Human Molecular Genetics·2008· 55 citedOpen Access
MCAK associates with EB1
Oncogene·2007· 68 cited
Examination of actin and microtubule dependent APC localisations in living mammalian cells
BMC Cell Biology·2006· 44 citedOpen Access
Adenomatous polyposis coli localization is both cell type and cell context dependent
Cell Motility and the Cytoskeleton·2006· 21 cited
Phenotypic changes associated with DYNACTIN‐2 (DCTN2) over expression characterise SJSA‐1 osteosarcoma cells
Molecular Carcinogenesis·2005· 13 cited
Trapping of normal EB1 ligands in aggresomes formed by an EB1 deletion mutant.
BMC Cell Biology·2005· 8 citedOpen Access
Expression of BUB1 protein in gastric cancer correlates with the histological subtype, but not with DNA ploidy or microsatellite instability
The Journal of Pathology·2003· 34 cited
Evidence That an Interaction between EB1 and p150 <sup>Glued</sup> Is Required for the Formation and Maintenance of a Radial Microtubule Array Anchored at the Centrosome
Molecular Biology of the Cell·2002· 188 citedOpen Access
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Frequent Co-authors

Ewan E. Morrison(19), Margaret A. Knowles(7), D M Meredith(5), Alexander F. Markham(5), Fiona M. Platt(5), Kelly Langford(4), Louis S. Pymar(4), Patricia M. Clissold(4), Sreenivasan Ponnambalam(4), Peter Moncur(3), Tracy Lee(3), Hema Viswambharan(3), V. Baliga(3), Nadira Yuldasheva(3), Sam L. Stephen(3), Ben Mercer(3), Mark Rakobowchuk(3), Piruthivi Sukumar(3), Anna Skromna(3), Karen E. Porter(3)