A. W. DOUGLAS

The University of Sydney — Australia

Chemistry · Physical Sciences

12h-index682citations48works4.32yr avg
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Research Topics

Analytical Chemistry and Chromatography(7), Chemical Synthesis and Analysis(7), Fluorine in Organic Chemistry(7), Synthesis and Biological Evaluation(6), Synthesis and Reactions of Organic Compounds(6)

Publications47 total

Pathway Of Low Anterior Resection syndrome (LARS) relief after Surgery (POLARiS): protocol for an international, open-label, multi-arm, phase 3 randomised superiority trial within a cohort, with economic evaluation, process evaluation and qualitative sub-study, to explore the natural history of LARS and compare transanal irrigation and sacral neuromodulation to optimised conservative management for people with major LARS following a high or low anterior resection for colorectal cancer
BMJ Open·2025· 4 citedOpen Access
Pathway of Low Anterior Resection Syndrome (LARS) Relief After Surgery (POLARiS) Trial Protocol A prospective, international, open-label, multi-arm, phase 3 randomised superiority trial within a cohort, with economic evaluation, process evaluation and qualitative sub-study, to explore the natural history of Low Anterior Resection Syndrome (LARS) and compare trans-anal irrigation and sacral neuromodulation to optimised conservative management for people with major LARS following a high or low anterior resection for colorectal cancer
2024Open Access
(Z)-フルオロ-オレフィンアミド生物同配体置換によるBACE1阻害剤の構造的に異なるシリーズの開発【JST・京大機械翻訳】
Bioorganic & Medicinal Chemistry Letters·2020
ChemInform Abstract: A Highly Efficient Synthesis of Fibrinogen Receptor Antagonist L‐734, 217 via a Novel Chemoselective Silyl‐Mediated Conjugate Addition of . delta.‐Lactams to 4‐Vinylpyridine.
ChemInform·1996
ChemInform Abstract: The Behavior of Indene Oxide in the Ritter Reaction: A Simple Route to cis‐Aminoindanol.
ChemInform·1995· 1 cited
ChemInform Abstract: Intramolecular Aromatic 1,5‐Hydrogen Transfer in Free Radical Reactions. Part 1. Unprecedented Rearrangements in Pschorr Cyclization, Sandmeyer, and Hydro‐, Hydroxy‐, and Iododediazoniation Reactions.
ChemInform·1995
ChemInform Abstract: Synthesis of a New Generation Reverse Transcriptase Inhibitor via the BCl3/GaCl3‐Induced Condensation of Anilines with Nitriles (Sugasawa Reaction).
ChemInform·1995
ChemInform Abstract: An Improved Method for Chiral Oxazaborolidine‐Catalyzed Reduction of 4‐ Chromanone Analogues and MK‐0499.
ChemInform·1995
In situ NMR spectroscopic studies of aniline ortho acylation (“sugasawa reaction”): The nature of reaction intermediates and Lewis acid influence on yield
Tetrahedron Letters·1994· 31 cited
ChemInform Abstract: Effects of Triethylamine in Asymmetric Reduction Using Oxazaborolidine Reagents.
ChemInform·1993
ChemInform Abstract: Iodotrimethylsilane‐Mediated 2‐Monohalogenation of 4‐Aza‐5α‐ androstan‐3‐one Steroids.
ChemInform·1993· 1 cited
ChemInform Abstract: A Practical Process for the Preparation of Tetrahydro‐1‐methyl‐3,3‐ diphenyl‐1H,3H‐pyrrolo(1,2‐c)(1,3,2)oxazaborole‐Bor ane. A Highly Enantioselective Stoichiometric and Catalytic Reducing Agent.
ChemInform·1993
ChemInform Abstract: An Unusual Fischer Indole Synthesis with 4‐Keto Acids: An Indole Incorporating the Terminal Hydrazine Nitrogen.
ChemInform·1990
ChemInform Abstract: Silylation‐Mediated Oxidation of 4‐Aza‐4‐ketosteroids with DDQ Proceeds via DDQ‐Substrate Adducts
ChemInform·1988
ChemInform Abstract: AMMONOLYSIS OF CEPHAMYCINS: CARBON‐13 NMR CHARACTERIZATION OF THE INTERMEDIATES FROM β‐LACTAM RING CLEAVAGE PRIOR TO LOSS OF THE 3′‐GROUP
Chemischer Informationsdienst·1985
Biosynthesis of the beta-lactam antibiotic, thienamycin, by Streptomyces cattleya.
Journal of Biological Chemistry·1985· 73 citedOpen Access
Synthesis of N2-[(S)-1-Carboxy-3-phenylpropyl]-L-lysyl-L-proline (Lisinopril)
Journal of Pharmaceutical Sciences·1985· 30 cited
Ammonolysis of cephamycins: carbon-13 NMR characterization of the intermediates from .beta.-lactam ring cleavage prior to loss of the 3'-group
Journal of the American Chemical Society·1985· 20 cited
ChemInform Abstract: THE MECHANISM OF SERINE FLUORODEHYDROXYLATION: CARBON‐13 AND FLUORINE‐19 NMR STUDIES
Chemischer Informationsdienst·1984
ChemInform Abstract: IMIDAZO(1,2‐A)PYRIDINE ANTHELMINTICS. SYNTHESIS OF 6‐PHENYLAMINOIMIDAZO(1,2‐A)PYRIDINE‐2‐CARBAMATE AND 5‐ACYLAMINOPYRIDINES BY A CHAPMAN REARRANGEMENT
Chemischer Informationsdienst·1981
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Frequent Co-authors

Edward J. J. Grabowski(8), Byron H. Arison(5), N. L. ABRAMSON(5), G. ALBERS‐SCHOENBERG(4), Richard L. Tolman(4), Sandor Karady(4), Paul J. Reider(4), Gordon B. Smith(3), Thomas R. Verhoeven(3), Seemon H. Pines(3), Ulf‐H. Dolling(3), John C. Chabala(2), Philip Eskola(2), M. H. FISHER(2), A Lusi(2), Helmut Mrozik(2), Jack L. Smith(2), Lolita O. Zamir(2), Roy A. Jensen(2), John R. Bowen(2)