K.R. Harrap

The University of Melbourne — Australia

Biochemistry, Genetics and Molecular Biology · Life Sciences

21h-index2.0kcitations49works18.02yr avg
OpenAlex↗Google Scholar↗Lab page↗

Accepting Students?

No reports yet. Know if this professor is taking students?

Research Topics

Biochemical and Molecular Research(17), Cancer therapeutics and mechanisms(8), Quinazolinone synthesis and applications(7), Metal complexes synthesis and properties(5), Ovarian cancer diagnosis and treatment(5)

Publications48 total

BRCA1 secondary splice-site mutations drive exon-skipping and PARP inhibitor resistance
Molecular Cancer·2024· 23 citedOpen Access
Timing of whole genome duplication is associated with tumor-specific MHC-II depletion in serous ovarian cancer
Nature Communications·2024· 13 citedOpen Access
Small-scale mutations are infrequent as mechanisms of resistance in post-PARP inhibitor tumour samples in high grade serous ovarian cancer
Scientific Reports·2023· 5 citedOpen Access
Refined cut-off for TP53 immunohistochemistry improves prediction of TP53 mutation status in ovarian mucinous tumors: implications for outcome analyses
Modern Pathology·2020· 38 citedOpen Access
Methylation of all BRCA1 copies predicts response to the PARP inhibitor rucaparib in ovarian carcinoma
Nature Communications·2018· 278 citedOpen Access
MyD88 and TLR4 Expression in Epithelial Ovarian Cancer
Mayo Clinic Proceedings·2018· 30 citedOpen Access
Biochemical Mechanisms of Resistance to Antimetabolites
Antibiotics and chemotherapy/Antibiotica et chemotherapia·2015· 17 cited
Phase I trial of ZD1694, a new folate-based thymidylate synthase inhibitor, in patients with solid tumors.
Journal of Clinical Oncology·1996· 74 cited
Initiatives with platinum- and quinazoline-based antitumor molecules--Fourteenth Bruce F. Cain Memorial Award Lecture.
PubMed·1995· 50 cited
Evaluation of novel ammine/amine platinum (IV) dicarboxylates in L1210 murine leukaemia cells sensitive and resistant to cisplatin, tetraplatin or carboplatin
British Journal of Cancer·1994· 19 citedOpen Access
Cisplatin Induces Apoptosis in a Human Ovarian Carcinoma Cell Line without Concomitant Internucleosomal Degradation of DNA
Experimental Cell Research·1994· 120 cited
New Approaches in Cancer Pharmacology: Drug Design and Development
British Journal of Cancer·1994Open Access
Lack of neurotoxicity of oral bisacetatoamminedichlorocyclohexylamine-platinum(IV) in comparison to cisplatin and tetraplatin in the rat.
PubMed·1994· 42 cited
Mechanism of action of an orally administered platinum complex [ammine bis butyrato cyclohexylamine dichloroplatinum (IV) (JM221)] in intrinsically cisplatin-resistant human ovarian carcinoma in vitro
British Journal of Cancer·1994· 17 citedOpen Access
Evaluation of novel platinum (II), and platinum (IV) ammine/amine complexes in L1210 murine leukaemia cell lines sensitive and resistant to cisplatin and tetraplatin
1993· 4 cited
Historical aspects of glutathione and cancer chemotherapy
Pharmacology & Therapeutics·1991· 39 cited
Thymidylate synthase: A target for anticancer drug design
Advances in Enzyme Regulation·1989· 51 cited
Drug Resistance as a Focus for New Drug Design
Elsevier eBooks·1988· 5 cited
ChemInform Abstract: Quinazoline Antifolates Inhibiting Thymidylate Synthase: Benzoyl Ring Modifications.
Chemischer Informationsdienst·1986
ChemInform Abstract: Quinazoline Antifolates Inhibiting Thymidylate Synthase: Variation of the Amino Acid.
Chemischer Informationsdienst·1986
page 1 of 3Next →

Frequent Co-authors

Nadia Traficante(8), Sián Fereday(8), David R. Newell(8), Georgia Chenevix‐Trench(7), Jillian A. Hung(7), G. A. Taylor(7), Penelope M. Webb(6), Dorota M. Gertig(6), T. Sadkowsky(6), Nirmala Pandeya(6), M. Malt(6), A. Mellon(6), R. Paul Robertson(6), T. Vanden Bergh(6), Terence R. Jones(6), David D.L. Bowtell(6), P. Mackenzie(5), J. Maidens(5), K. Nattress(5), Yoke-Eng Chiew(5)