Daniel E. Koshland

Biochemistry, Genetics and Molecular Biology · Life Sciences

101h-index40.9kcitations653works0.02yr avg
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Research Topics

Protein Structure and Dynamics(70), Enzyme Structure and Function(61), Hemoglobin structure and function(45), Bacterial Genetics and Biotechnology(30), Photoreceptor and optogenetics research(29)

Publications653 total

Habituation in the single cell: Diminished secretion of norepinephrine with repetitive depolarization of PC12 cells (memory/protein phosphorylation/protein kinase C/phorbol esters/calcium)
2016
The Contribution of Orientation to the Catalytic Power of Enzymes
2015· 3 cited
The seven pillars of life
Cambridge University Press eBooks·2010
The Cha-Cha-Cha Theory of Scientific Discovery
Science·2007· 59 cited
Frank H. Westheimer (1912–2007)
ACS Chemical Biology·2007
Insights into the serine protease mechanism from atomic resolution structures of trypsin reaction intermediates
Proceedings of the National Academy of Sciences·2006· 146 citedOpen Access
guanidinobenzoyl-trypsin acyl-enzyme at 1.13 A resolution
2005
The leupeptin-trypsin covalent complex at 1.14 A resolution
2005
Role of the Intramolecular Hydrogen Bond Network in the Inhibitory Power of Chymotrypsin Inhibitor 2<sup>,</sup>
Biochemistry·2005· 39 cited
Stolen Slides
IUBMB Life·2005Open Access
Crystal structure of the complex of subtilisin BPN' with chymotrypsin inhibitor 2 R67A mutant
2004
Crazy, but correct
Nature·2004· 18 citedOpen Access
Crystal structure of the complex of subtilisin BPN' with chymotrypsin inhibitor 2 E60A mutant
2004
Crystal structure of the complex of subtilisin BPN' with chymotrypsin inhibitor 2 T58P mutant
2004
Crystal structure of the complex of subtilisin BPN' with chymotrypsin inhibitor 2 T58A mutant
2004
Binding, Proteolytic, and Crystallographic Analyses of Mutations at the Protease−Inhibitor Interface of the Subtilisin BPN‘/Chymotrypsin Inhibitor 2 Complex<sup>,</sup>
Biochemistry·2004· 46 cited
crystal structure of the complex of subtilisin BPN' with chymotrypsin inhibitor 2 Y61A mutant
2004
crystal structure of the complex of subtilisin BPN' with chymotrypsin inhibitor 2 M59K, in pH 9 cryosoak
2004
crystal structure of the complex of subtilisin BPN' with chymotrypsin inhibitor 2 M59A mutant
2004
crystal structure of the complex of subtilisin BPN' with chymotrypsin inhibitor 2 M59k mutant
2004
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Frequent Co-authors

Albert Goldbeter(3), D C LaPorte(3), Robert M. Macnab(2), Kenneth Neet(2), Jeffry B. Stock(2), Daniel L. Milligan(2), Alexander Levitzki(2), Kermit L. Carraway(2), James H. Hurley(2), Antony M. Dean(2), Robert M. Stroud(2), William J. Ray(2), Kenneth A. Walsh(2), George Némethy(1), D. Filmer(1), D. G. Hoare(1), Elizabeth Culotta(1), John L. Spudich(1), Ruth Levy Guyer(1), Abby. Conway(1)