David Flowers

Medicine · Health Sciences

21h-index4.4kcitations71works0.92yr avg
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Research Topics

Monoclonal and Polyclonal Antibodies Research(19), Cancer Immunotherapy and Biomarkers(17), CAR-T cell therapy research(16), Cardiac electrophysiology and arrhythmias(14), Cardiac Arrhythmias and Treatments(10)

Publications71 total

Anti‐ <scp>PD</scp> ‐(L)1 Antibodies: Insights From <scp>QSP</scp> ‐Based Meta‐Analysis
CPT Pharmacometrics & Systems Pharmacology·2026Open Access
A Tutorial on the Development of a Physiologically Inspired <scp>PKRO</scp> Model for Monoclonal Antibodies
CPT Pharmacometrics & Systems Pharmacology·2025Open Access
Comparison of dose selection based on target engagement versus inhibition of receptor–ligand interaction for checkpoint inhibitors
CPT Pharmacometrics & Systems Pharmacology·2024· 1 citedOpen Access
Supplementary Table S3 from ATG-101 Is a Tetravalent PD-L1×4-1BB Bispecific Antibody That Stimulates Antitumor Immunity through PD-L1 Blockade and PD-L1–Directed 4-1BB Activation
2024Open Access
Supplementary Table S6 from ATG-101 Is a Tetravalent PD-L1×4-1BB Bispecific Antibody That Stimulates Antitumor Immunity through PD-L1 Blockade and PD-L1–Directed 4-1BB Activation
2024Open Access
Supplementary Table S6 from ATG-101 Is a Tetravalent PD-L1×4-1BB Bispecific Antibody That Stimulates Antitumor Immunity through PD-L1 Blockade and PD-L1–Directed 4-1BB Activation
2024Open Access
Data from ATG-101 Is a Tetravalent PD-L1×4-1BB Bispecific Antibody That Stimulates Antitumor Immunity through PD-L1 Blockade and PD-L1–Directed 4-1BB Activation
2024Open Access
Supplementary Data from ATG-101 Is a Tetravalent PD-L1×4-1BB Bispecific Antibody That Stimulates Antitumor Immunity through PD-L1 Blockade and PD-L1–Directed 4-1BB Activation
2024Open Access
Supplementary Data from ATG-101 Is a Tetravalent PD-L1×4-1BB Bispecific Antibody That Stimulates Antitumor Immunity through PD-L1 Blockade and PD-L1–Directed 4-1BB Activation
2024Open Access
Data from ATG-101 Is a Tetravalent PD-L1×4-1BB Bispecific Antibody That Stimulates Antitumor Immunity through PD-L1 Blockade and PD-L1–Directed 4-1BB Activation
2024Open Access
Supplementary Table S3 from ATG-101 Is a Tetravalent PD-L1×4-1BB Bispecific Antibody That Stimulates Antitumor Immunity through PD-L1 Blockade and PD-L1–Directed 4-1BB Activation
2024Open Access
Supplementary Table S5 from ATG-101 Is a Tetravalent PD-L1×4-1BB Bispecific Antibody That Stimulates Antitumor Immunity through PD-L1 Blockade and PD-L1–Directed 4-1BB Activation
2024Open Access
Supplementary Table S4 from ATG-101 Is a Tetravalent PD-L1×4-1BB Bispecific Antibody That Stimulates Antitumor Immunity through PD-L1 Blockade and PD-L1–Directed 4-1BB Activation
2024Open Access
Supplementary Table S5 from ATG-101 Is a Tetravalent PD-L1×4-1BB Bispecific Antibody That Stimulates Antitumor Immunity through PD-L1 Blockade and PD-L1–Directed 4-1BB Activation
2024Open Access
Supplementary Table S4 from ATG-101 Is a Tetravalent PD-L1×4-1BB Bispecific Antibody That Stimulates Antitumor Immunity through PD-L1 Blockade and PD-L1–Directed 4-1BB Activation
2024Open Access
Respiratory Syncytial Virus in a Child With Dravet Syndrome: A Case Report
Cureus·2024· 1 citedOpen Access
ATG-101 Is a Tetravalent PD-L1×4-1BB Bispecific Antibody That Stimulates Antitumor Immunity through PD-L1 Blockade and PD-L1–Directed 4-1BB Activation
Cancer Research·2024· 16 citedOpen Access
Blinatumomab Trimer Formation: Insights From A Mechanistic PKPD Model Into The Implications For Switching From Infusion To Subcutaneous Dosing Regimen
2024Open Access
Impact of PD-L2 on Relative Efficacy of Anti-PD-1 and Anti-PD-L1 Antibodies: Insights From QSP-Based Meta-Analysis
2024Open Access
A next generation mathematical model for the in vitro to clinical translation of T-cell engagers
Journal of Pharmacokinetics and Pharmacodynamics·2023· 16 cited
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Frequent Co-authors

Irwin D. Bernstein(19), John C. Somberg(14), Vilma Torres(13), Dennis S. Miura(11), Barbara Varnum‐Finney(7), Deborah Keefe(7), Brenda Butler(6), Carolyn Brashem‐Stein(5), Cynthia Nourigat(5), David Tepper(4), Jonathan Wynn(4), Hui Yuwen(4), Huajing Wang(4), Tengteng Li(4), Yijing Ren(4), Yun-kai Zhang(4), Peng Chen(4), Ao Sun(4), Gang Bian(4), Bohua Li(4)