Tzyh‐Chang Hwang

Medicine · Health Sciences

34h-index3.1kcitations87works0.02yr avg
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Research Topics

Cystic Fibrosis Research Advances(64), Advanced biosensing and bioanalysis techniques(44), Ion channel regulation and function(21), Neonatal Respiratory Health Research(19), Drug Transport and Resistance Mechanisms(13)

Publications87 total

Cystic Fibrosis and the CFTR Anion Channels
2023
Decision letter: Molecular pathology of the R117H cystic fibrosis mutation is explained by loss of a hydrogen bond
2021Open Access
Positional effects of premature termination codons on the biochemical and biophysical properties of CFTR
The Journal of Physiology·2019· 23 citedOpen Access
Identifying the molecular target sites for CFTR potentiators GLPG1837 and VX-770
The Journal of General Physiology·2019· 70 citedOpen Access
Functional characterization reveals that zebrafish CFTR prefers to occupy closed channel conformations
PLoS ONE·2018· 16 citedOpen Access
Structural mechanisms for defective CFTR gating caused by the Q1412X mutation, a severe Class VI pathogenic mutation in cystic fibrosis
The Journal of Physiology·2018· 15 citedOpen Access
Characterization of Δ(G970-T1122)-CFTR, the most frequent CFTR mutant identified in Japanese cystic fibrosis patients
The Journal of Physiological Sciences·2018· 7 citedOpen Access
Physiological and pharmacological characterization of the N1303K mutant CFTR
Journal of Cystic Fibrosis·2018· 37 citedOpen Access
Structural mechanisms of CFTR function and dysfunction
The Journal of General Physiology·2018· 130 citedOpen Access
A common mechanism for CFTR potentiators
The Journal of General Physiology·2017· 61 citedOpen Access
CFTR potentiators: from bench to bedside
Current Opinion in Pharmacology·2017· 39 citedOpen Access
Electrostatic tuning of the pre- and post-hydrolytic open states in CFTR
The Journal of General Physiology·2017· 13 citedOpen Access
Synergistic Potentiation of Cystic Fibrosis Transmembrane Conductance Regulator Gating by Two Chemically Distinct Potentiators, Ivacaftor (VX-770) and 5-Nitro-2-(3-Phenylpropylamino) Benzoate
Molecular Pharmacology·2016· 33 citedOpen Access
Spatial positioning of CFTR’s pore-lining residues affirms an asymmetrical contribution of transmembrane segments to the anion permeation pathway
The Journal of General Physiology·2016· 13 citedOpen Access
On the mechanism of gating defects caused by the R117H mutation in cystic fibrosis transmembrane conductance regulator
The Journal of Physiology·2016· 41 citedOpen Access
The Fifth Transmembrane Segment of Cystic Fibrosis Transmembrane Conductance Regulator Contributes to Its Anion Permeation Pathway
Biochemistry·2015· 20 cited
Cystic brosis and the CFTR anion channel
2015
Localizing a gate in CFTR
Proceedings of the National Academy of Sciences·2015· 48 citedOpen Access
Cystic Fibrosis and the CFTR Anion Channel
2015· 7 cited
Potentiation of CFTR Gating by an Energetically Additive Mechanism
Biophysical Journal·2015Open Access
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Frequent Co-authors

Yoshiro Sohma(18), Min Li(11), Silvia G. Bompadre(9), Kang‐Yang Jih(6), Xiaoqin Zou(6), Jiunn‐Tyng Yeh(5), Zhen Zhou(5), Jingyao Zhang(4), Han‐I Yeh(4), David N. Sheppard(3), Xiaohui Wang(3), Yonghong Bai(3), Shenghui Hu(3), Tomohiko Ai(3), Xiaolong Gao(3), Yingchun Yu(3), Wen‐Ying Lin(3), Fei Wang(2), Shawn Zeltwanger(2), Ying-Chun Yu(2)