Pierre‐Alain Carrupt

HES-SO University of Applied Sciences and Arts Western Switzerland — Switzerland

Chemistry · Physical Sciences

66h-index14.5kcitations381works0.02yr avg
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Research Topics

Analytical Chemistry and Chromatography(80), Computational Drug Discovery Methods(60), Free Radicals and Antioxidants(42), Electrochemical Analysis and Applications(25), Chemical and Physical Properties in Aqueous Solutions(23)

Publications381 total

Zebrafish bioassay-guided isolation of antiseizure compounds from the Cameroonian medicinal plant Cyperus articulatus L
Phytomedicine·2020· 28 cited
Establishment of a Human 3D Tissue-Based Assay for Upper Respiratory Tract Absorption
Applied In Vitro Toxicology·2018· 28 citedOpen Access
CCDC 959986: Experimental Crystal Structure Determination
The Cambridge Structural Database·2018Open Access
Passive Intestinal Absorption of Representative Plant Secondary Metabolites: A Physicochemical Study
Planta Medica·2017· 5 cited
HDM-PAMPA to predict gastrointestinal absorption, binding percentage, equilibrium and kinetics constants with human serum albumin and using 2 end-point measurements
European Journal of Pharmaceutical Sciences·2016· 20 cited
Human sirtuins: Structures and flexibility
Journal of Structural Biology·2016· 44 cited
A Rational Approach for the Identification of Non-Hydroxamate HDAC6-Selective Inhibitors
Scientific Reports·2016· 37 citedOpen Access
Normal phase HPLC-based activity profiling of non-polar crude plant extracts – acetylcholinesterase inhibiting guttiferones from <i>Montrouziera cauliflora</i> as a case study
Natural Product Research·2016· 3 citedOpen Access
Limits of rapid log P determination methods for highly lipophilic and flexible compounds
Analytica Chimica Acta·2016· 10 cited
Prediction of the Passive Intestinal Absorption of Medicinal Plant Extract Constituents with the Parallel Artificial Membrane Permeability Assay (PAMPA)
Planta Medica·2016· 42 citedOpen Access
5-Benzylidene-hydantoin is a new scaffold for SIRT inhibition: From virtual screening to activity assays
European Journal of Pharmaceutical Sciences·2016· 17 cited
Molecular dynamics of zinc-finger ubiquitin binding domains: a comparative study of histone deacetylase 6 and ubiquitin-specific protease 5
Journal of Biomolecular Structure and Dynamics·2015· 13 cited
Pharmacophore‐based discovery of inhibitors of a novel drug/proton antiporter in human brain endothelial hCMEC/D3 cell line
British Journal of Pharmacology·2015· 46 citedOpen Access
Modification of a PAMPA model to predict passive gastrointestinal absorption and plasma protein binding
European Journal of Pharmaceutical Sciences·2015· 18 cited
Structure-Based Design and Optimization of Multitarget-Directed 2<i>H</i>-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases
Journal of Medicinal Chemistry·2015· 98 citedOpen Access
Inhibition screening method of microsomal UGTs using the cocktail approach
European Journal of Pharmaceutical Sciences·2015· 21 cited
How the flexibility of human histone deacetylases influences ligand binding: an overview
Drug Discovery Today·2015· 35 cited
Alkaloids from Psychotria Target Sirtuins: In Silico and In Vitro Interaction Studies
Planta Medica·2014· 14 citedOpen Access
Retention time prediction for dereplication of natural products (CxHyOz) in LC–MS metabolite profiling
Phytochemistry·2014· 54 cited
Aurones as histone deacetylase inhibitors: Identification of key features
Bioorganic & Medicinal Chemistry Letters·2014· 38 citedOpen Access
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Frequent Co-authors

Bernard Testa(30), Marianne Reist(9), Hubert H. Girault(8), Angelo Carotti(7), Marco Catto(6), Patrick Gaillard(6), Cosimo Altomare(5), Frédéric Reymond(5), Patrizia Crivori(4), Jean‐Luc Veuthey(4), Sophie Martel(4), Kurt Hostettmann(4), Nabil El Tayar(4), Ruey‐Shiuan Tsai(4), Giulia Caron(4), Géraldine Bouchard(4), Francesco Leonetti(3), Andrew Marston(3), Juan Bravo(3), Françoise Brée(3)