Kashi Javaherian

Tufts University — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

26h-index5.1kcitations47works0.02yr avg
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Research Topics

Angiogenesis and VEGF in Cancer(19), HIV Research and Treatment(14), Cell Adhesion Molecules Research(9), Monoclonal and Polyclonal Antibodies Research(9), Glycosylation and Glycoproteins Research(8)

Publications47 total

SIV Neutralization Epitopes
Chemical immunology/Fortschritte der Allergielehre/Progress in allergy/Chemical immunology and allergy·2015
Inhibition of Corneal Neovascularization by Subconjunctival Injection of Fc-Endostatin, a Novel Inhibitor of Angiogenesis
Journal of Ophthalmology·2015· 10 citedOpen Access
Beneficial Effects of Combined Antiangiogenesis and Heavy Ion Radiation Therapy
International Journal of Radiation Oncology*Biology*Physics·2012
Endostatin lowers blood pressure via nitric oxide and prevents hypertension associated with VEGF inhibition
Proceedings of the National Academy of Sciences·2012· 49 citedOpen Access
Improvement in the standard treatment for experimental glioma by fusing antibody Fc domain to endostatin
Journal of neurosurgery·2011· 11 cited
Inhibition Of Angiogenesis By Fc-endostatin
2011
Two Endogenous Antiangiogenic Inhibitors, Endostatin and Angiostatin, Demonstrate Biphasic Curves in their Antitumor Profiles
Dose-Response·2010· 26 citedOpen Access
HSPG-Binding Peptide Corresponding to the Exon 6a-Encoded Domain of VEGF Inhibits Tumor Growth by Blocking Angiogenesis in Murine Model
PLoS ONE·2010· 35 citedOpen Access
Angiostatin regulates the expression of antiangiogenic and proapoptotic pathways via targeted inhibition of mitochondrial proteins
Blood·2009· 44 citedOpen Access
Identification of novel Angiostatin binding partners using a protein array (27K) based high-throughput protein-protein-interaction screen
Cancer Research·2008· 1 cited
Linking Antibody Fc Domain to Endostatin Significantly Improves Endostatin Half-life and Efficacy
Clinical Cancer Research·2008· 52 citedOpen Access
Improved pharmacokinetics and efficacy of endostatin by fusion with IgG Fc domain
2007· 1 cited
The Morphogenic Properties of Oligomeric Endostatin Are Dependent on Cell Surface Heparan Sulfate
Journal of Biological Chemistry·2006· 9 citedOpen Access
Endostatin therapy reveals a U-shaped curve for antitumor activity
Cancer Gene Therapy·2006· 61 cited
Short synthetic endostatin peptides inhibit endothelial migration in vitro and endometriosis in a mouse model
Fertility and Sterility·2006· 59 cited
Endostatin binds biglycan and LDL and interferes with LDL retention to the subendothelial matrix during atherosclerosis
Journal of Lipid Research·2005· 57 citedOpen Access
A 27-Amino-Acid Synthetic Peptide Corresponding to the NH2-Terminal Zinc-Binding Domain of Endostatin Is Responsible for Its Antitumor Activity
Cancer Research·2005· 106 cited
Oligomeric collagen XVIII‐derived endostatin requires cell surface heparan sulfate in order to induce morphological changes in endothelial and epithelial cell lines <i>in vitro</i>
International Journal of Experimental Pathology·2004Open Access
Binding of endostatin to endothelial heparan sulphate shows a differential requirement for specific sulphates
Biochemical Journal·2003· 40 citedOpen Access
Inhibition of plaque neovascularization reduces macrophage accumulation and progression of advanced atherosclerosis
Proceedings of the National Academy of Sciences·2003· 650 citedOpen Access
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Frequent Co-authors

Judah Folkman(14), A J Langlois(10), Kin-Ming Lo(8), Stephen D. Gillies(6), Scott D. Putney(6), Thomas J. Matthews(6), Dani P. Bolognesi(5), Robert M. Tjin Tham Sjin(4), Gordon C. Jayson(4), David Zurakowski(3), J R Rusche(3), Charlene McDanal(3), Amy E. Birsner(3), Tong-Young Lee(3), James R. Rusche(3), Amir Abdollahi(3), Fiona Blackhall(3), Catherine L.R. Merry(3), Gregory J. LaRosa(3), Betty Tyler(3)