Philippe Champeil

Université Paris-Sud — France

Biochemistry, Genetics and Molecular Biology · Life Sciences

38h-index4.8kcitations101works0.02yr avg
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Research Topics

Ion channel regulation and function(44), ATP Synthase and ATPases Research(31), Lipid Membrane Structure and Behavior(28), Ion Transport and Channel Regulation(28), Cardiac electrophysiology and arrhythmias(14)

Publications101 total

Interaction of detergents with biological membranes: Comparison of fluorescence assays with filtration protocols and implications for the rates of detergent association, dissociation and flip-flop
PLoS ONE·2019· 5 citedOpen Access
High phosphatidylinositol 4-phosphate (PI4P)-dependent ATPase activity for the Drs2p-Cdc50p flippase after removal of its N- and C-terminal extensions
Journal of Biological Chemistry·2017· 35 citedOpen Access
Slow Phospholipid Exchange between a Detergent-Solubilized Membrane Protein and Lipid-Detergent Mixed Micelles: Brominated Phospholipids as Tools to Follow Its Kinetics
PLoS ONE·2017· 9 citedOpen Access
A robust method to screen detergents for membrane protein stabilization, revisited
Analytical Biochemistry·2016· 19 cited
On the molecular mechanism of flippase- and scramblase-mediated phospholipid transport
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids·2015· 100 cited
Coordinated Overexpression in Yeast of a P4-ATPase and Its Associated Cdc50 Subunit: The Case of the Drs2p/Cdc50p Lipid Flippase Complex
Methods in molecular biology·2015· 13 cited
ATPase activities of various streptavidin-purified samples.
Figshare·2015Open Access
A High-Yield Co-Expression System for the Purification of an Intact Drs2p-Cdc50p Lipid Flippase Complex, Critically Dependent on and Stabilized by Phosphatidylinositol-4-Phosphate
PLoS ONE·2014· 29 citedOpen Access
Overexpression of Membrane Proteins in Saccharomyces cerevisiae for Structural and Functional Studies: A Focus on the Rabbit Ca2+-ATPase Serca1a and on the Yeast Lipid “Flippase” Complex Drs2p/Cdc50p
2014· 7 citedOpen Access
Phosphatidylserine stimulation of Drs2p·Cdc50p lipid translocase dephosphorylation is controlled by phosphatidylinositol-4-phosphate.
Journal of Biological Chemistry·2012· 1 citedOpen Access
Phosphatidylserine Stimulation of Drs2p·Cdc50p Lipid Translocase Dephosphorylation Is Controlled by Phosphatidylinositol-4-phosphate
Journal of Biological Chemistry·2012· 58 citedOpen Access
Amphipols From A to Z
Annual Review of Biophysics·2011· 243 citedOpen Access
Inhibition by 4-hydroxynonenal (HNE) of Ca2+ transport by SERCA1a: Low concentrations of HNE open protein-mediated leaks in the membrane
Free Radical Biology and Medicine·2011· 2 cited
Erratum to “Inhibition by 4-hydroxynonenal (HNE) of Ca2+ transport by SERCA1a: Low concentrations of HNE open protein-mediated leaks in the membrane” [Free Radic. Biol. Med. 50 (2011) 323–336]
Free Radical Biology and Medicine·2011· 2 cited
Inhibition by 4-hydroxynonenal (HNE) of Ca2+ transport by SERCA1a: Low concentrations of HNE open protein-mediated leaks in the membrane
Free Radical Biology and Medicine·2010· 11 cited
Glycyl betaine is effective in slowing down the irreversible denaturation of a detergent-solubilized membrane protein, sarcoplasmic reticulum Ca2+-ATPase (SERCA1a)
Biochemical and Biophysical Research Communications·2009· 6 cited
Use of Glycerol-Containing Media To Study the Intrinsic Fluorescence Properties of Detergent-Solubilized Native or Expressed SERCA1a
Biochemistry·2008· 15 cited
Unexpected Phosphoryl Transfer from Asp<sup>351</sup> to Fluorescein Attached to Lys515 in Sarcoplasmic Reticulum Ca<sup>2+</sup>-ATPase
Biochemistry·2008· 5 cited
Crystal Structure of D351A and P312A Mutant Forms of the Mammalian Sarcoplasmic Reticulum Ca2+-ATPase Reveals Key Events in Phosphorylation and Ca2+ Release
Journal of Biological Chemistry·2008· 35 citedOpen Access
Crystal structure of D351A mutant forms of the mammalian sarcoplasmic reticulum CA2+-ATPase reveals key events in phosphorylation and CA2+ release
HAL (Le Centre pour la Communication Scientifique Directe)·2008
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Frequent Co-authors

Marc le Maire(17), Jesper V. Møller(11), Florent Guillain(11), Laurent Combettes(9), Stéphane Orlowski(7), Cédric Montigny(7), M.P. Gingold(6), Sten Lund(5), M Claret(5), Guillaume Lenoir(5), Béatrice de Foresta(4), Poul Nissen(4), Martin Picard(3), Francesco Michelangeli(3), S. Swillens(3), Manuel Garrigos(3), Jens Peter Andersen(3), Birte Juul(3), Adrienne Gomez de Gracia(3), Aurore Jacquot(3)