Takeshi Matsuzaki

Yakult Central Institute — Japan

Agricultural and Biological Sciences · Life Sciences

31h-index4.0kcitations87works0.02yr avg
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Research Topics

Probiotics and Fermented Foods(19), Cancer Research and Treatments(11), Gut microbiota and health(9), Cancer therapeutics and mechanisms(9), Synthesis and biological activity(6)

Publications87 total

Semisynthesis of Antitrypanosomal <i>p</i>-Quinone Analog Possesing the Komaroviquinone Pharmacophore
Chemical and Pharmaceutical Bulletin·2022· 1 citedOpen Access
Novel Pan-Pim Kinase Inhibitors With Imidazopyridazine and Thiazolidinedione Structure Exert Potent Antitumor Activities
Frontiers in Pharmacology·2021· 19 citedOpen Access
Semisynthesis of Triptolide Analogues Part IV: Effects of C-14 Carbamothioate Substituents on Cytotoxic Activities
Heterocycles·2019Open Access
Rational Design of a Potent Pan-Pim Kinases Inhibitor with a Rhodanine–Benzoimidazole Structure
Anticancer Research·2017· 18 citedOpen Access
YPC‐21661 and YPC‐22026, novel small molecules, inhibit ZNF143 activity <i>in vitro</i> and <i>in vivo</i>
Cancer Science·2017· 21 citedOpen Access
Establishment of a Novel In Vitro Model for Predicting Incidence and Severity of Microtubule-targeting Agent-induced Peripheral Neuropathy.
PubMed·2015· 5 cited
Abstract 5534: A novel and oral histone deacetylase inhibitor, resminostat, effectively suppresses the growth of non-small cell lung cancer in a xenograft mouse model
Cancer Research·2014· 1 cited
Antitumor effect of a novel phenanthroindolizidine alkaloid derivative through inhibition of protein synthesis.
PubMed·2014· 14 cited
Wasabi-Derived 6-(Methylsulfinyl)Hexyl Isothiocyanate Induces Apoptosis in Human Breast Cancer by Possible Involvement of the NF-κB Pathways
Nutrition and Cancer·2014· 26 cited
4-Chlorocolchicine derivatives bearing a thiourea side chain at the C-7 position as potent anticancer agents
MedChemComm·2014· 14 cited
Abstract 3994: Perifosine, an AKT inhibitor, downregulates mTOR function and suppresses the growth of human gastric cancer cells in mice.
Cancer Research·2013
ABCG2 inhibitor YHO-13351 sensitizes cancer stem/initiating-like side population cells to irinotecan.
PubMed·2013· 23 cited
PEGylated liposome IHL-305 markedly improved the survival of ovarian cancer peritoneal metastasis in mouse
BMC Cancer·2012· 9 citedOpen Access
Comparative studies of irinotecan-loaded polyethylene glycol-modified liposomes prepared using different PEG-modification methods
Biochimica et Biophysica Acta (BBA) - Biomembranes·2012· 34 cited
Synthesis of Phenanthroindolizidine Alkaloids with an Acyloxy Group at the C3 Position and their Antitumor Activities and Toxicities
Letters in Drug Design & Discovery·2012· 3 cited
Synthesis and biological evaluation of 4-chlorocolchicine derivatives as potent anticancer agents with broad effective dosage ranges
MedChemComm·2012· 9 cited
Bacterial Production of the Tunicate-Derived Antitumor Cyclic Depsipeptide Didemnin B
Journal of Natural Products·2011· 113 cited
Synthesis of phenanthroindolizidine alkaloids and evaluation of their antitumor activities and toxicities
Bioorganic & Medicinal Chemistry Letters·2011· 18 cited
Novel Acrylonitrile Derivatives, YHO-13177 and YHO-13351, Reverse BCRP/ABCG2-Mediated Drug Resistance<i>In Vitro</i>and<i>In Vivo</i>
Molecular Cancer Therapeutics·2011· 45 citedOpen Access
ChemInform Abstract: Asymmetric Synthesis of Phenanthroindolizidine Alkaloids with Hydroxyl Group at the C14 Position and Evaluation of Their Antitumor Activities.
ChemInform·2011
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Frequent Co-authors

Teruo Yokokura(21), Shusuke Hashimoto(13), Ryuta Yamazaki(12), Akimitsu Takagi(8), Ritsuo Aiyama(7), Masato Nagaoka(5), Yutaka Aoyagi(5), Shinichi Kawai(4), Haruhiko Fukaya(4), S Hashimoto(3), Natsuko Kusunoki(3), Masatoshi Watanabe(3), Yoshifumi Hirokawa(3), Taizo Shiraishi(3), Yoshiyuki Shishido(3), Fukiko Nishisaka(3), Masahiko Mutai(3), Yoshinao Takahashi(3), Koichi Takeya(3), Teruo Kurihara(3)