Bernárd P. Roques

Centre National de la Recherche Scientifique — France

Neuroscience · Life Sciences

77h-index24.9kcitations463works0.02yr avg
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Research Topics

Neuropeptides and Animal Physiology(194), Receptor Mechanisms and Signaling(96), Peptidase Inhibition and Analysis(82), HIV Research and Treatment(71), Pain Mechanisms and Treatments(54)

Publications463 total

Molecular mechanisms in Alzheimer's disease and related potential treatments such as structural target convergence of antibodies and simple organic molecules
European Journal of Medicinal Chemistry·2022· 36 cited
Aminopeptidase A contributes to biochemical, anatomical and cognitive defects in Alzheimer’s disease (AD) mouse model and is increased at early stage in sporadic AD brain
Acta Neuropathologica·2021· 21 citedOpen Access
Positive allosteric modulation of the mu-opioid receptor produces analgesia with reduced side effects
Proceedings of the National Academy of Sciences·2021· 73 citedOpen Access
BRAIN-PENETRATING AMINOPEPTIDASE A INHIBITORS FOR NEW TREATMENT OF HYPERTENSION AND HEART FAILURE
Journal of Hypertension·2021
Structural insight into the catalytic mechanism and inhibitor binding of aminopeptidase A
Biochemical Journal·2020· 1 citedOpen Access
NI956/QGC006, a Potent Orally Active, Brain-Penetrating Aminopeptidase A Inhibitor for Treating Hypertension
Hypertension·2019· 30 citedOpen Access
Development and Test of a 400-kV PFN Marx With Compactness and Rise Time Optimization
IEEE Transactions on Plasma Science·2018· 35 cited
Obligatory Metabolism of Angiotensin II to Angiotensin III for Zona Glomerulosa Cell–Mediated Relaxations of Bovine Adrenal Cortical Arteries
Endocrinology·2017· 5 citedOpen Access
Substituted α-mercaptoketones, new types of specific neprilysin inhibitors
Bioorganic & Medicinal Chemistry Letters·2017· 3 citedOpen Access
Synergistic combinations of the dual enkephalinase inhibitor PL265 given orally with various analgesic compounds acting on different targets, in a murine model of cancer-induced bone pain
Scandinavian Journal of Pain·2016· 22 citedOpen Access
Preventive and alleviative effects of the dual enkephalinase inhibitor (Denki) PL265 in a murine model of neuropathic pain
European Journal of Pharmacology·2016· 17 cited
Progress in rapid screening o lethal factor activity
2016
Contribution of Delta-Opioid Receptors to Pathophysiological Events Explored by Endogenous Enkephalins
Handbook of experimental pharmacology·2016· 11 cited
Modulation of disulfide dual ENKephalinase inhibitors (DENKIs) activity by a transient N-protection for pain alleviation by oral route
European Journal of Medicinal Chemistry·2015· 4 citedOpen Access
Long‐lasting oral analgesic effects of<i>N</i>‐protected aminophosphinic dual<scp>ENK</scp>ephalinase inhibitors (<scp>DENKI</scp>s) in peripherally controlled pain
Pharmacology Research & Perspectives·2015· 22 citedOpen Access
New Orally Active Dual Enkephalinase Inhibitors (DENKIs) for Central and Peripheral Pain Treatment
Journal of Medicinal Chemistry·2014· 51 citedOpen Access
TGF-β and Opioid Receptor Signaling Crosstalk Results in Improvement of Endogenous and Exogenous Opioid Analgesia under Pathological Pain Conditions
Journal of Neuroscience·2014· 40 citedOpen Access
Cocaine Dysregulates Opioid Gating of GABA Neurotransmission in the Ventral Pallidum
Journal of Neuroscience·2014· 52 citedOpen Access
Randomised, Double-Blind, Placebo-Controlled, Dose-Escalating Phase I Study of QGC001, a Centrally Acting Aminopeptidase A Inhibitor Prodrug
Clinical Pharmacokinetics·2013· 56 cited
A sensitive fluorigenic substrate for selective in vitro and in vivo assay of leukotriene A4 hydrolase activity
Analytical Biochemistry·2013· 13 cited
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Frequent Co-authors

Florence Noble(10), Marie‐Claude Fournié‐Zaluski(10), Olga Valverde(5), Catherine Llorens‐Cortés(5), Rafaël Maldonado(4), Eleni T. Tzavara(4), F. Beslot(3), Jacques Hanoune(3), G. Gacel(3), Cynthia Marie‐Claire(3), Catherine Ledent(2), Marc Parmentier(2), Étienne Jacotot(2), Markus Loeffler(2), Karine F. Ferri(2), Helena L.A. Vieira(2), Naoufal Zamzami(2), Sabine Druillennec(2), Johan Hoebeke(2), Zhi Hua Xie(2)