Denise Howe

Heptares Therapeutics (United Kingdom) — United Kingdom

Medicine · Health Sciences

12h-index1.4kcitations31works3.02yr avg
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Research Topics

Chronic Lymphocytic Leukemia Research(14), Lymphoma Diagnosis and Treatment(12), T-cell and B-cell Immunology(3), Cancer-related Molecular Pathways(3), Viral-associated cancers and disorders(3)

Publications31 total

679TiP Cancer Research UK phase I/IIa trial of the prostaglandin E2 (PGE2) receptor 4 (EP4) antagonist HTL0039732 as monotherapy and in combination with immunotherapy in patients (pts) with advanced solid tumors
Annals of Oncology·2024· 3 cited
037 – The Magnetic Resonance Imaging Adventure
Journal of Pediatric Nursing·2009Open Access
Simultaneous analysis of cell surface antigens and DNA content by flow cytometry
Clinical & Laboratory Haematology·2008
Analysis of ZAP-70 Expression in Chronic Lymphocytic Leukemia (CLL) Using Kolmogorov-Smirnov (KS) Statistics.
Blood·2007
Spectrum of p53 mutations in low-grade B-cell malignancies
Leukemia·2007· 2 cited
Expression of ZAP‐70 in patients with chronic lymphocytic leukemia may change significantly during the course of the disease: response to <i>Smolej et al.</i>
International Journal of Laboratory Hematology·2007
Letter to the Editor
International Journal of Laboratory Hematology·2007· 5 citedOpen Access
Letter to the Editor
Clinical & Laboratory Haematology·2007
Variation of LEF-1 mRNA expression in low-grade B-cell non-Hodgkin's lymphoma
Leukemia Research·2005· 24 cited
Comparison of flow cytometric methods for the measurement of ZAP-70 expression in a routine diagnostic laboratory
Clinical & Laboratory Haematology·2005· 53 cited
The cyclin D1 alternative transcripts [a] and [b] are expressed in normal and malignant lymphocytes and their relative levels are influenced by the polymorphism at codon 241.
PubMed·2001· 65 cited
Benign monoclonal expansion of CD8+ lymphocytes in HIV infection
Journal of Clinical Pathology·2000· 72 citedOpen Access
Simple, reliable detection of T cell clones by PCR-LIS-SSCP analysis of TCRγ rearrangement
Molecular and Cellular Probes·1998· 12 cited
Heterogeneity of clonal lymphocytes with regard to bcl-2 protein concentration and cell size.
Molecular Pathology·1997Open Access
Additional TCRV beta primers and minor method modifications improve detection of clonal T-cell populations by RT-PCR.
Molecular Pathology·1997· 8 citedOpen Access
Trisomy 12 is a Rare Event in Cases of CLL with Typical Immunophenotype and Morphology
Hematology·1997· 7 citedOpen Access
Further improvement of t(8;21) detection by RT-PCR.
PubMed·1996
t(8;21) detection by RT‐PCR: an improved primer set convenient for the routine laboratory
British Journal of Haematology·1995· 5 cited
Adaptation of the TdT assay for semi‐quantitative flow cytometric detection of DNA strand breaks
Cytometry·1995· 28 citedOpen Access
Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism.
Proceedings of the National Academy of Sciences·1995· 938 citedOpen Access
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Frequent Co-authors

Stephen A. Johnson(11), Teresa Bromidge(10), M. J. Phillips(7), Caroline Lynas(6), Graham Gibbs(5), Julie Clements(4), J. A. Hopkins(3), Deborah Richardson(2), John A. Hopkins(2), Marion Sweeney(2), Jody Clements(2), David S. Quinn(2), Michael Datto(1), Y Li(1), Joanne Fanelli Panus(1), Yin Xiong(1), X F Wang(1), H. Frei(1), F.E. Würgler(1), Penelope R Smith(1)