C. James

Immunology and Microbiology · Life Sciences

26h-index1.9kcitations65works0.02yr avg
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Research Topics

Parasites and Host Interactions(29), Parasite Biology and Host Interactions(27), Cancer therapeutics and mechanisms(17), Synthesis and pharmacology of benzodiazepine derivatives(17), Helminth infection and control(16)

Publications65 total

Refutation of Reverse Derivative Categories
2019
Evaluation of the taste-masking effects of (2-hydroxypropyl)-β-cyclodextrin on ranitidine hydrochloride; a combined biosensor, spectroscopic and molecular modelling assessment
RSC Advances·2018· 44 citedOpen Access
Synthesis, anti-mycobacterial activity and DNA sequence-selectivity of a library of biaryl-motifs containing polyamides
Bioorganic & Medicinal Chemistry·2015· 12 cited
Effect of hairpin loop structure on reactivity, sequence preference and adduct orientation of a DNA-interactive pyrrolo[2,1-c][1,4]benzodiazepine (PBD) antitumour agent
Organic & Biomolecular Chemistry·2015· 8 cited
Computational Studies Support the Role of the C7-Sibirosamine Sugar of the Pyrrolobenzodiazepine (PBD) Sibiromycin in Transcription Factor Inhibition
ACS Chemical Biology·2014· 14 cited
An Extended Pyrrolobenzodiazepine–Polyamide Conjugate with Selectivity for a DNA Sequence Containing the ICB2 Transcription Factor Binding Site
Journal of Medicinal Chemistry·2013· 30 cited
Abstract 1129: GC-t8-linked pyrrolobenzodiazepine (PBD)-biaryl conjugates with femptomolar i<i>n vitro</i> cytotoxicity and <i>in vivo</i> antitumour activity in mouse models of pancreatic and breast cancer.
Cancer Research·2013· 5 cited
GC-Targeted C8-Linked Pyrrolobenzodiazepine–Biaryl Conjugates with Femtomolar in Vitro Cytotoxicity and in Vivo Antitumor Activity in Mouse Models
Journal of Medicinal Chemistry·2013· 63 cited
Antistaphylococcal activity of DNA-interactive pyrrolobenzodiazepine (PBD) dimers and PBD-biaryl conjugates
Journal of Antimicrobial Chemotherapy·2012· 25 citedOpen Access
Observation of a Single-Stranded DNA/Pyrrolobenzodiazepine Adduct
Journal of the American Chemical Society·2011· 27 cited
Novel C8-linked pyrrolobenzodiazepine (PBD)–heterocycle conjugates that recognize DNA sequences containing an inverted CCAAT box
Bioorganic & Medicinal Chemistry Letters·2011· 19 cited
Abstract 2321: Pyrrolobenzodiazepine (PBD) antitumour agents as chemical probes to determine the number of base pairs required for DNA minor groove structure
Cancer Research·2011
Effect of base sequence on the DNA cross-linking properties of pyrrolobenzodiazepine (PBD) dimers
Nucleic Acids Research·2011· 43 citedOpen Access
Observation of the reversibility of a covalent pyrrolobenzodiazepine (PBD) DNA adduct by HPLC/MS and CD spectroscopy
Organic & Biomolecular Chemistry·2011· 28 cited
528 Observation of the reversibility of formation of a pyrrolobenzodiazepine (PBD) covalent DNA adduct using HPLC/MS and CD spectroscopy
European Journal of Cancer Supplements·2010
DNA Sequence Preference and Adduct Orientation of Pyrrolo[2,1-<i>c</i>][1,4]benzodiazepine Antitumor Agents
ACS Medicinal Chemistry Letters·2010· 35 cited
Abstract 3506: Rules of DNA adduct formation for pyrrolobenzodiazepine (PBD) dimers
Cancer Research·2010
Structure−Activity Relationships of Monomeric C2-Aryl Pyrrolo[2,1-<i>c</i>][1,4]benzodiazepine (PBD) Antitumor Agents
Journal of Medicinal Chemistry·2010· 40 cited
The Pyrrolobenzodiazepine Dimer SJG-136 Forms Sequence-Dependent Intrastrand DNA Cross-Links and Monoalkylated Adducts in Addition to Interstrand Cross-Links
Journal of the American Chemical Society·2009· 77 cited
Microtubule plus‐end and minus‐end capture at adherens junctions is involved in the assembly of apico‐basal arrays in polarised epithelial cells
Cell Motility and the Cytoskeleton·2009· 73 cited
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Frequent Co-authors

G. Webbe(19), David E. Thurston(14), Khondaker Miraz Rahman(11), Philip W. Howard(7), John A. Hartley(6), Paul J. Jackson(5), G. S. Nelson(5), Keith R. Fox(4), Terence C. Jenkins(4), María de la Fuente(3), Federico Brucoli(3), Ritika R. Kapoor(2), Khalid Hussain(2), Trevor G. Smart(2), Mathangi Narayanaswamy(2), Bristi Basu(2), Andreas G. Schätzlein(2), Chris Pepper(2), S. K. Prah(2), Higia Vassoler(2)