Sheng-Chieh Hsu

National Health Research Institutes — Taiwan

Biochemistry, Genetics and Molecular Biology · Life Sciences

17h-index2.3kcitations18works1.02yr avg
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Research Topics

Epigenetics and DNA Methylation(4), Lung Cancer Treatments and Mutations(4), HER2/EGFR in Cancer Research(4), Drug Transport and Resistance Mechanisms(3), Cancer, Hypoxia, and Metabolism(3)

Publications18 total

Identifying Rare Germline Variants Associated with Metastatic Prostate Cancer Through an Extreme Phenotype Study
2025· 1 citedOpen Access
Arginine Signaling and Cancer Metabolism
Cancers·2021· 250 citedOpen Access
Arginine is an epigenetic regulator targeting TEAD4 to modulate OXPHOS in prostate cancer cells
Nature Communications·2021· 121 citedOpen Access
Arginine starvation elicits chromatin leakage and cGAS-STING activation via epigenetic silencing of metabolic and DNA-repair genes
Theranostics·2021· 50 citedOpen Access
Mutations in the PKM2 exon-10 region are associated with reduced allostery and increased nuclear translocation
Communications Biology·2019· 29 citedOpen Access
KDM8/JMJD5 as a dual coactivator of AR and PKM2 integrates AR/EZH2 network and tumor metabolism in CRPC
Oncogene·2018· 95 citedOpen Access
Human ATP-Binding Cassette Transporter ABCB1 Confers Resistance to Volasertib (BI 6727), a Selective Inhibitor of Polo-like Kinase 1
Molecular Pharmaceutics·2015· 30 cited
BCRP/ABCG2 Inhibition Sensitizes Hepatocellular Carcinoma Cells to Sorafenib
PLoS ONE·2013· 74 citedOpen Access
Elevated BCRP/ABCG2 Expression Confers Acquired Resistance to Gefitinib in Wild-Type EGFR-Expressing Cells
PLoS ONE·2011· 78 citedOpen Access
Nuclear Translocation of Epidermal Growth Factor Receptor by Akt-dependent Phosphorylation Enhances Breast Cancer-resistant Protein Expression in Gefitinib-resistant Cells
Journal of Biological Chemistry·2011· 191 citedOpen Access
Identification of the methylation preference region in heterogeneous nuclear ribonucleoprotein K by protein arginine methyltransferase 1 and its implication in regulating nuclear/cytoplasmic distribution
Biochemical and Biophysical Research Communications·2010· 25 cited
Acetylation of EGF receptor contributes to tumor cell resistance to histone deacetylase inhibitors
Biochemical and Biophysical Research Communications·2010· 46 cited
RNA helicase A is a DNA-binding partner for EGFR-mediated transcriptional activation in the nucleus
Proceedings of the National Academy of Sciences·2010· 113 citedOpen Access
Epidermal Growth Factor Receptor Cooperates with Signal Transducer and Activator of Transcription 3 to Induce Epithelial-Mesenchymal Transition in Cancer Cells via Up-regulation of <i>TWIST</i> Gene Expression
Cancer Research·2007· 625 citedOpen Access
Characterization of a Novel Tripartite Nuclear Localization Sequence in the EGFR Family
Journal of Biological Chemistry·2007· 247 citedOpen Access
EGFR signaling pathway in breast cancers: from traditional signal transduction to direct nuclear translocalization
Breast Cancer Research and Treatment·2005· 234 cited
VariedImmunity Generated in Mice by DNA Vaccines with Large and SmallHepatitis DeltaAntigens
Journal of Virology·2003· 21 citedOpen Access
DNA-based immunization produces Th1 immune responses to hepatitis delta virus in a mouse model
Hepatology·2000· 26 cited

Frequent Co-authors

Mien‐Chie Hung(7), Hsing-Jien Kung(5), David K. Ann(4), Chia‐Lin Chen(3), Yun Yen(3), Wei‐Chien Huang(3), Long‐Yuan Li(3), Hui‐Wen Lo(2), Weiya Xia(2), Yun‐Ju Chen(2), Ya-Ling Wei(2), Ying‐Nai Wang(2), Chung‐Hsuan Chen(2), Hung-Jung Wang(2), Shauh-Der Yeh(2), Chang‐Hai Tsai(2), Hung-Jung Wang(2), Cheng-Ying Chu(2), Chien‐Feng Li(2), Wen‐Ching Wang(2)