Sharron H. Francis

Cape Fear Valley Medical Center — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

56h-index12.2kcitations168works0.02yr avg
OpenAlex↗Google Scholar↗Lab page↗

Accepting Students?

No reports yet. Know if this professor is taking students?

Research Topics

Phosphodiesterase function and regulation(116), Nitric Oxide and Endothelin Effects(38), Cholinesterase and Neurodegenerative Diseases(27), Sexual function and dysfunction studies(25), Receptor Mechanisms and Signaling(23)

Publications167 total

272: APATHETIC THYROID STORM WITH THYROTOXICOSIS-INDUCED CARDIOMYOPATHY
Critical Care Medicine·2025
Crystal Structures of Phosphodiesterases 4 and 5 in Complex with Inhibitor 3-Isobutyl-1-methylxanthine Suggest a Conformation Determinant of Inhibitor Selectivity
UNC Libraries·2021Open Access
Multiple Conformations of Phosphodiesterase-5: IMPLICATIONS FOR ENZYME FUNCTION AND DRUG DEVELOPMENT
UNC Libraries·2021· 6 citedOpen Access
Amino-Acid Sequence of the Variable Rep of a Mouse Myeloma Protein with Anti-H-
2016
The design and construction of a prototype lateral-transfer retro-reflector for inter-satellite laser ranging
Classical and Quantum Gravity·2014· 16 cited
Second Messengers | Cyclic Nucleotide-Dependent Protein Kinases
Elsevier eBooks·2013
Second Messengers | Cyclic GMP Phosphodiesterases
Elsevier eBooks·2013
Calcineurin Regulates Homologous Desensitization of Natriuretic Peptide Receptor-A and Inhibits ANP-Induced Testosterone Production in MA-10 Cells
PLoS ONE·2012· 9 citedOpen Access
PDE5 inhibitors: targeting erectile dysfunction in diabetics
Current Opinion in Pharmacology·2011· 43 cited
Conformational conversion of PDE5 by incubation with sildenafil or metal ion is accompanied by stimulation of allosteric cGMP binding
Cellular Signalling·2011· 6 cited
Mammalian Cyclic Nucleotide Phosphodiesterases: Molecular Mechanisms and Physiological Functions
Physiological Reviews·2011· 626 cited
Phosphodiesterases as Drug Targets
Handbook of experimental pharmacology·2011· 43 cited
Phosphodiesterase Inhibitors: Factors That Influence Potency, Selectivity, and Action
Handbook of experimental pharmacology·2011· 58 cited
Metal ion stimulators of PDE5 cause similar conformational changes in the enzyme as does cGMP or sildenafil
Cellular Signalling·2010· 4 cited
Use of a Schizosaccharomyces pombe PKA-repressible reporter to study cGMP metabolising phosphodiesterases
Cellular Signalling·2010· 18 cited
The Role of cGMP-Dependent Protein Kinase in Controlling Cardiomyocyte cGMP
Circulation Research·2010· 22 citedOpen Access
Inhibition of Cyclic Nucleotide Phosphodiesterases by Methylxanthines and Related Compounds
Handbook of experimental pharmacology·2010· 66 cited
cGMP-Dependent Protein Kinases and cGMP Phosphodiesterases in Nitric Oxide and cGMP Action
Pharmacological Reviews·2010· 990 citedOpen Access
Phosphodiesterase-5
Elsevier eBooks·2010· 2 cited
Regulation of Cyclic Nucleotide Levels by Sequestration
Elsevier eBooks·2010· 6 cited
page 1 of 9Next →

Frequent Co-authors

Jackie D. Corbin(49), Alfreda Beasley(8), Illarion V. Turko(6), Mitsi A. Blount(5), Janet L. Colbran(5), Linda M. McAllister‐Lucas(5), Roya Zoraghi(5), Melissa K. Thomas(4), Konjeti R. Sekhar(4), Kennard A. Grimes(4), Emmanuel P. Bessay(3), Hengming Ke(3), Jun Kotera(3), Hang Jiang(2), Jack N. Wells(2), Vincent A. Florio(2), William K. Sonnenburg(2), Dalia Seger(2), Kenneth A. Walsh(2), Yudong Liu(2)