Yoshiaki Isobe

Sumitomo Dainippon Pharma (Japan) — Japan

Neuroscience · Life Sciences

29h-index2.6kcitations163works0.02yr avg
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Research Topics

Circadian rhythm and melatonin(30), Neuroendocrine regulation and behavior(17), Quinazolinone synthesis and applications(15), Photoreceptor and optogenetics research(9), Stress Responses and Cortisol(8)

Publications162 total

Discovery of N-(6-(5-fluoro-2-(piperidin-1-yl)phenyl)pyridazin-3-yl)-1-(tetrahydro-2H-pyran-4-yl)methanesulfonamide as a brain-permeable and metabolically stable kynurenine monooxygenase inhibitor
Bioorganic & Medicinal Chemistry Letters·2021· 7 citedOpen Access
Identification of 2-fluoro-8-methyl-11-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-5H-dibenzo[b,e][1,4]diazepine with clozapine-like mixed activities at muscarinic acetylcholine, dopamine, and serotonin receptors
Bioorganic & Medicinal Chemistry Letters·2021Open Access
N-(6-phenylpyridazin-3-yl)benzenesulfonamides as highly potent, brain-permeable, and orally active kynurenine monooxygenase inhibitors
Bioorganic & Medicinal Chemistry Letters·2020· 13 citedOpen Access
Structural analysis reveals TLR7 dynamics underlying antagonism
Nature Communications·2020· 62 citedOpen Access
Synthesis and pharmacological evaluation of 11-(1,6-dimethyl-1,2,3,6-tetrahydropyridin-4-yl)-5H-dibenzo[b,e][1,4]diazepines with clozapine-like receptor occupancy at dopamine D1/D2 receptor
Bioorganic & Medicinal Chemistry Letters·2020· 1 citedOpen Access
Numerical fluid dynamics on the effects of morphology and kinematics of fish on the propulsion performance
The Proceedings of Conference of Kansai Branch·2019
Synthesis and biological evaluation of novel orally available 1-phenyl-6-aminouracils containing dimethyldihydrobenzofuranol structure for the treatment of allergic skin diseases
Bioorganic & Medicinal Chemistry Letters·2016· 3 cited
Dihydropyrrolo[2,3-<i>d</i>]pyrimidines: Selective Toll-Like Receptor 9 Antagonists from Scaffold Morphing Efforts
ACS Medicinal Chemistry Letters·2014· 28 citedOpen Access
Crystal Structures and Structure–Activity Relationships of Imidazothiazole Derivatives as IDO1 Inhibitors
ACS Medicinal Chemistry Letters·2014· 141 citedOpen Access
Synthesis of Novel Benzo-Fused Heteroaryl Derivatives as Ca&lt;sup&gt;2+&lt;/sup&gt;/Calmodulin-Dependent Protein Kinase II Inhibitors
Chemical and Pharmaceutical Bulletin·2013· 10 citedOpen Access
Synthesis and evaluation of 8-oxoadenine derivatives as potent Toll-like receptor 7 agonists with high water solubility
Bioorganic & Medicinal Chemistry Letters·2012· 33 citedOpen Access
Synthesis and structure based optimization of 2-(4-phenoxybenzoyl)-5-hydroxyindole as a novel CaMKII inhibitor
Bioorganic & Medicinal Chemistry·2012· 10 cited
ChemInform Abstract: Suzuki—Miyaura Cross‐Coupling Reaction of Aryl and Heteroaryl Pinacol Boronates for the Synthesis of 2‐Substituted Pyrimidines.
ChemInform·2012
Suzuki–Miyaura cross-coupling reaction of aryl and heteroaryl pinacol boronates for the synthesis of 2-substituted pyrimidines
Tetrahedron·2011· 21 cited
Circadian rhythm of metabolic oscillation in suprachiasmatic nucleus depends on the mitochondrial oxidation state, reflected by cytochrome C oxidase and lactate dehydrogenase
Journal of Neuroscience Research·2011· 37 cited
Circadian rhythm of enolase in suprachiasmatic nucleus depends on mitochondrial function
Journal of Neuroscience Research·2011· 8 citedOpen Access
Synthesis and structure–activity relationship of tricyclic carboxylic acids as novel anti-histamines
Bioorganic & Medicinal Chemistry·2011· 32 citedOpen Access
Structure and activity relationship of 2-(substituted benzoyl)-hydroxyindoles as novel CaMKII inhibitors
Bioorganic & Medicinal Chemistry Letters·2011· 4 cited
5,6,7,8-Tetrahydropyrido[4,3-d]pyrimidines as novel class of potent and highly selective CaMKII inhibitors
Bioorganic & Medicinal Chemistry Letters·2010· 13 citedOpen Access
Synthesis and Biological Evaluation of 8-Oxoadenine Derivatives as Toll-like Receptor 7 Agonists Introducing the Antedrug Concept
Journal of Medicinal Chemistry·2010· 49 citedOpen Access
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Frequent Co-authors

Masanori Tobe(13), Kosaku Hirota(9), Hideya Hayashi(8), Hitoo Nishino(8), Haruo Takaku(7), Haruhisa Ogita(7), Ayumu Kurimoto(6), Fujiya Furuyama(6), Hideyuki Tomizawa(5), Takahiro Nagasaki(4), Hironao Sajiki(4), Tetsuhiro Ogino(4), Hajime Kawakami(4), Hideki Hida(4), Yoshifumi Maki(4), Hitoo Nishino(4), Shigehiro Asano(3), Shinji Ichii(3), Tadashi Masuda(3), Sachiyo Misumi(3)