Michael Schleimer

Basilea Pharmaceutica (Switzerland) — Switzerland

Chemistry · Physical Sciences

14h-index1.0kcitations20works0.02yr avg
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Research Topics

Analytical Chemistry and Chromatography(12), Microfluidic and Capillary Electrophoresis Applications(5), Mass Spectrometry Techniques and Applications(4), Chromatography in Natural Products(4), Pharmacogenetics and Drug Metabolism(3)

Publications20 total

Experiments for a systematic comparison between stable-isotope-(deuterium) labeling and radio-(14C) labeling for the elucidation of the in vitro metabolic pattern of pharmaceutical drugs
Journal of Pharmaceutical and Biomedical Analysis·2013· 6 cited
Preformulation Approaches to Improve the Oral Bioavailability of Two Novel Piperidine Renin Inhibitors in Dog
Arzneimittelforschung·2011· 4 cited
Investigation of the species-dependent in vitro metabolism of BAL30630 by stable isotope labeling and isotope exchange experiments analyzed by capillary liquid chromatography coupled to mass spectrometry
Journal of Chromatography A·2009· 9 cited
Elucidation of the <i>in vitro</i> metabolic profile of stable isotope labeled BAL19403 by accurate mass capillary liquid chromatography/quadrupole time‐of‐flight mass spectrometry and isotope exchange
Rapid Communications in Mass Spectrometry·2007· 16 cited
Investigation of low‐abundant <i>in vitro</i> metabolites of stable isotope‐labelled BAL4815 by accurate mass capillary‐LC‐ESI‐qTof‐MS and MS/MS
Journal of Mass Spectrometry·2006· 7 citedOpen Access
Single-Ascending-Dose Pharmacokinetics and Safety of the Novel Broad-Spectrum Antifungal Triazole BAL4815 after Intravenous Infusions (50, 100, and 200 Milligrams) and Oral Administrations (100, 200, and 400 Milligrams) of Its Prodrug, BAL8557, in Healthy Volunteers
Antimicrobial Agents and Chemotherapy·2005· 169 citedOpen Access
Single-Dose Pharmacokinetics and Safety of a Novel Broad-Spectrum Cephalosporin (BAL5788) in Healthy Volunteers
Antimicrobial Agents and Chemotherapy·2004· 101 citedOpen Access
Multiple-Dose Pharmacokinetics and Safety of a Novel Broad-Spectrum Cephalosporin (BAL5788) in Healthy Volunteers
Antimicrobial Agents and Chemotherapy·2004· 78 cited
Performance and reliability of splitless microliter gradient pumps in a metabolic stability study using cytochrome P450/3A4 and capillary liquid chromatography–mass spectrometry
Journal of Chromatography A·2003· 7 cited
Potential inhibitory effects of formulation ingredients on intestinal cytochrome P450
International Journal of Pharmaceutics·2000· 101 cited
The effect of tolcapone on the pharmacokinetics of benserazide
European Journal of Neurology·1999· 13 citedOpen Access
Enantiomer Separation by Capillary SFC and GC on Chirasil-Nickel: Observation of Unusual Peak Broadening Phenomena
Analytical Chemistry·1994· 27 cited
Enantiomer separation by high-performance liquid chromatography on polysiloxane-based chiral stationary phases
Journal of Chromatography A·1994· 28 cited
Dual chiral recognition system involving cyclodextrin derivatives in capillary electrophoresis
Journal of Microcolumn Separations·1994· 84 cited
Enantiomer separation by complexation gas and supercritical fluid chromatography on immobilized polysiloxane-bonded nickel(II) bis[(3-heptafluorobutanoyl)-10-methylene-(1R)-camphorate] (Chirasil-nickel)
Journal of Chromatography A·1993· 28 cited
Investigation of the Enantiomerization Barrier of Homofuran by Computer Simulation of Interconversion Profiles Obtained by Complexation Gas Chromatography
Chemische Berichte·1992· 52 cited
Enantiomer Separation by Capillary Supercritical Fluid Chromatography
1992· 15 cited
Enantiomer Separation on Immobilized Chirasil‐Metal and Chirasil‐Dex by Gas Chromatography and Supercritical Fluid Chromatography
Angewandte Chemie International Edition in English·1991· 112 cited
Enantiomerentrennung an immobilisiertem Chirasil‐Metall und Chirasil‐Dex durch Gaschromatographie und Chromatographie mit überkritischen Gasen
Angewandte Chemie·1991· 40 cited
Gas chromatographic enantiomer separation on polysiloxane‐anchored permethyl‐β‐cyclodextrin (Chirasil‐Dex)
Journal of High Resolution Chromatography·1990· 143 cited

Frequent Co-authors

Volker Schurig(9), Anne Schmitt‐Hoffmann(7), Mathias Wind(4), Klaus Gebhardt(4), Brigitte Roos(3), E. Weidekamm(3), Dieter Schmalzing(3), Helge Grunwald(3), Jochen Spickermann(3), Pascal Fullhardt(3), Dominique Klauer(3), Martin Jung(2), J. Sauer(2), Anthony Man(2), Norman Nashed(2), Tom Brown(2), Beate Bittner(2), Massimiliano Donzelli(2), M. Heep(1), Thomas A. Brown(1)