Fumiya Obata

Medicine · Health Sciences

24h-index4.1kcitations98works0.02yr avg
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Research Topics

Parkinson's Disease Mechanisms and Treatments(23), T-cell and B-cell Immunology(19), Immune Cell Function and Interaction(18), Renal Transplantation Outcomes and Treatments(9), Alzheimer's disease research and treatments(7)

Publications98 total

Generation of gene-corrected iPSCs line (KEIUi001-A) from a PARK8 patient iPSCs with familial Parkinson’s disease carrying the I2020T mutation in LRRK2
Stem Cell Research·2020· 8 citedOpen Access
Leucine-Rich Repeat Kinase 2 Controls Inflammatory Cytokines Production through NF-κB Phosphorylation and Antigen Presentation in Bone Marrow-Derived Dendritic Cells
International Journal of Molecular Sciences·2020· 15 citedOpen Access
LRRK2におけるI2020T変異を有する家族性Parkinson病を有するPARK8患者iPSCからの遺伝子補正iPSCs系統(KEIUi001-A)の生成【JST・京大機械翻訳】
Stem Cell Research (Web)·2020
Enhanced activated T�cell subsets in prostate cancer patients receiving iodine-125 low-dose-rate prostate brachytherapy
Oncology Reports·2017· 24 cited
Generation of a mouse model of familial Parkinson’s disease bearing patient iPSC-derived transplanted neurospheres
Journal of the Neurological Sciences·2017
Establishment of DYT5 patient-specific induced pluripotent stem cells with a GCH1 mutation
Stem Cell Research·2017· 1 citedOpen Access
Leucine-rich repeat kinase 2 (LRRK2) regulates α-synuclein clearance in microglia
BMC Neuroscience·2016· 62 citedOpen Access
Instruction and evaluation for children with profound and multiple disabilities who utilized line of sight input device
IEICE Technical Report; IEICE Tech. Rep.·2016
Analysis of possible suppression mechanisms for HIV-1 replication in CD4+ T cells co-cultured with alloantigen-stimulated CD8+ T cells
Kitasato medical journal·2016
Leucine-rich repeat kinase 2 is a regulator of B cell function, affecting homeostasis, BCR signaling, IgA production, and TI antigen responses
Journal of Neuroimmunology·2016· 21 cited
I2020T LRRK2 iPSC-derived neurons in the Sagamihara family exhibit increased Tau phosphorylation through the AKT/GSK-3beta signaling pathway
Parkinsonism & Related Disorders·2015
Effect of LRRK2-mediated phosphorylation on the ability of tau to bind to tubulin.
Figshare·2015Open Access
I2020T mutant LRRK2 iPSC-derived neurons in the Sagamihara family exhibit increased Tau phosphorylation through the AKT/GSK-3β signaling pathway
Human Molecular Genetics·2015· 66 citedOpen Access
Enhanced central memory cluster of differentiation 8+ and tumor antigen-specific T cells in prostate cancer patients receiving repeated in situ adenovirus-mediated suicide gene therapy
Molecular and Clinical Oncology·2015· 9 citedOpen Access
The mouse/human cross-species heterodimer of leucine-rich repeat kinase 2: Possible significance in the transgenic model mouse of Parkinson’s disease
Neuroscience Letters·2015· 3 cited
Allo-Antigen Stimulated CD8+ T-Cells Suppress NF-κB and Ets-1 DNA Binding Activity, and Inhibit Phosphorylated NF-κB p65 Nuclear Localization in CD4+ T-cells
Viral Immunology·2014Open Access
[Pathogenesis of Parkinson's disease through LRRK2 mutation].
PubMed·2014
Dominant-negative effects of LRRK2 heterodimers: A possible mechanism of neurodegeneration in Parkinson’s disease caused by LRRK2 I2020T mutation
Biochemical and Biophysical Research Communications·2012· 15 cited
Broad spectrum of dystonia associated with a novel thanatosis‐associated protein domain‐containing apoptosis‐associated protein 1 mutation in a Japanese family with dystonia 6, torsion
Movement Disorders·2012· 7 cited
The I2020T Leucine-rich repeat kinase 2 transgenic mouse exhibits impaired locomotive ability accompanied by dopaminergic neuron abnormalities
Molecular Neurodegeneration·2012· 42 citedOpen Access
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Frequent Co-authors

Etsuro Ohta(16), Noboru Kashiwagi(10), Tatsunori Maekawa(8), Kazuko Hasegawa(7), Manabu Funayama(6), Makoto Kubo(6), Fumitaka Kawakami(5), Hiroyoshi Komatsu(5), Sadahiro Azuma(4), Shiro Baba(4), Makoto Kubo(4), Ichiro Ito(4), Takehisa Kaneko(4), Hisayuki Kowa(3), Matthew J. Farrer(3), Jack Silver(3), M Ohkubo(3), Yasuo Takeuchi(3), Ryuichi Nagashima(3), Koji Eshima(3)