Tracy J. Jenkins

Chemistry · Physical Sciences

12h-index592citations16works0.02yr avg
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Research Topics

Asymmetric Synthesis and Catalysis(4), Chronic Lymphocytic Leukemia Research(4), Synthetic Organic Chemistry Methods(4), Chemokine receptors and signaling(3), Lymphoma Diagnosis and Treatment(2)

Publications16 total

Discovery of structural diverse reversible BTK inhibitors utilized to develop a novel in vivo CD69 and CD86 PK/PD mouse model
Bioorganic & Medicinal Chemistry Letters·2022· 2 citedOpen Access
Utilizing structure based drug design and metabolic soft spot identification to optimize the in vitro potency and in vivo pharmacokinetic properties leading to the discovery of novel reversible Bruton’s tyrosine kinase inhibitors
Bioorganic & Medicinal Chemistry·2021· 11 citedOpen Access
Optimization of novel reversible Bruton’s tyrosine kinase inhibitors identified using Tethering-fragment-based screens
Bioorganic & Medicinal Chemistry·2019· 15 citedOpen Access
CDK12-mediated transcriptional regulation of noncanonical NF-κB components is essential for signaling
Science Signaling·2018· 38 cited
Antagonism of chemokine receptor CCR8 is ineffective in a primate model of asthma
Thorax·2013· 17 citedOpen Access
Structures of human Bruton's tyrosine kinase in active and inactive conformations suggest a mechanism of activation for TEC family kinases
Protein Science·2010· 148 citedOpen Access
Design, Synthesis, and Evaluation of Naphthalene-Sulfonamide Antagonists of Human CCR8
Journal of Medicinal Chemistry·2007· 37 citedOpen Access
Identification and characterization of 4-aryl-3,4-dihydropyrimidin-2(1H)-ones as inhibitors of the fatty acid transporter FATP4
Bioorganic & Medicinal Chemistry Letters·2006· 73 citedOpen Access
Design, Synthesis, and Progress toward Optimization of Potent Small Molecule Antagonists of CC Chemokine Receptor 8 (CCR8)
Journal of Medicinal Chemistry·2006· 37 citedOpen Access
Structure−Activity Relationships of a Series of Pyrrolo[3,2-<i>d</i>]pyrimidine Derivatives and Related Compounds as Neuropeptide Y5 Receptor Antagonists
Journal of Medicinal Chemistry·2000· 84 citedOpen Access
Geminal Acylation with Methyl-Substituted Analogues of 1,2-Bis[(trimethylsilyl)oxy]cyclobutene
The Journal of Organic Chemistry·1997· 16 cited
The kinetic mechanism of the interaction of p21ras with neurofibromin
UCL Discovery (University College London)·1997
Synthesis, X-ray Structure, and Properties of Fluorocyclopropane Analogs of the Duocarmycins Incorporating the 9,9-Difluoro-1,2,9,9a-tetrahydrocyclopropa[<i>c</i>]benzo[<i>e</i>]indol-4-one (F<sub>2</sub>CBI) Alkylation Subunit
Journal of the American Chemical Society·1996· 62 cited
Lewis Acid Catalyzed Geminal Acylation Reaction of Ketones with 1,2-Bis[(trimethylsilyl)oxy]cyclobutene: Direct Formation of 2,2-Disubstituted 1,3-Cyclopentanediones
The Journal of Organic Chemistry·1994· 35 cited
Geminal acylation of ketones, methodology, and applications to natural product syntheses
Memorial University Research Repository (Memorial University)·1994
Formation of 2,2-disubstituted 1,3-cyclopentanediones from ketals with 1,2-bis(trimethylsilyloxy)cyclobutene
Canadian Journal of Chemistry·1993· 17 citedOpen Access

Frequent Co-authors

Brian T. Hopkins(5), D.J. Marcotte(4), Patrick Cullen(4), Elisabeth Mertsching(4), Laura Silvian(4), Bing Guan(4), M.J. Romanowski(3), Roland Kolbeck(3), D. Jean Burnell(3), Tonika Bohnert(3), Jon K. Bowden-Verhoek(3), Patrick R. Conlon(3), Ella Negrou(3), Yuting Liu(2), Robert M. Arduini(2), Darren P. Baker(2), Christopher Blackburn(2), Shomir Ghosh(2), Robert A. Bennett(2), Sean M. Smith(2)