Kaoru Saigo

The University of Tokyo — Japan

Biochemistry, Genetics and Molecular Biology · Life Sciences

50h-index6.7kcitations127works0.02yr avg
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Research Topics

Developmental Biology and Gene Regulation(28), RNA Interference and Gene Delivery(24), Neurobiology and Insect Physiology Research(18), Chromosomal and Genetic Variations(18), Advanced biosensing and bioanalysis techniques(17)

Publications127 total

RNAi-mediated knockdown of mouse melanocortin-4 receptor <i>in vitro</i> and <i>in vivo</i>, using an siRNA expression construct based on the mir-187 precursor
EXPERIMENTAL ANIMALS·2016Open Access
Multipotent versus differentiated cell fate selection in the developing Drosophila airways
eLife·2015· 4 citedOpen Access
Author response: Multipotent versus differentiated cell fate selection in the developing Drosophila airways
2015Open Access
The Intersection of the Extrinsic Hedgehog and WNT/Wingless Signals with the Intrinsic Hox Code Underpins Branching Pattern and Tube Shape Diversity in the Drosophila Airways
PLoS Genetics·2015· 11 citedOpen Access
Interactions between the non-seed region of siRNA and RNA-binding RLC/RISC proteins, Ago and TRBP, in mammalian cells
Nucleic Acids Research·2014· 32 citedOpen Access
Enhanced specificity of HPV16 E6E7 siRNA by RNA–DNA chimera modification
Cancer Gene Therapy·2011· 13 cited
Cooperative DNA‐binding and sequence‐recognition mechanism of aristaless and clawless
The EMBO Journal·2010· 45 citedOpen Access
Reduced base-base interactions between the DNA seed and RNA target are the major determinants of a significant reduction in the off-target effect due to DNA-seed-containing siRNA
2009· 2 cited
RNAi-Mediated Knockdown Showing Impaired Cell Survival in <i>Drosophila</i> Wing Imaginal Disc
Gene Regulation and Systems Biology·2009· 17 citedOpen Access
Thermodynamic stability and Watson–Crick base pairing in the seed duplex are major determinants of the efficiency of the siRNA-based off-target effect
Nucleic Acids Research·2008· 179 citedOpen Access
DNA-modified siRNA-dependent gene silencing with reduced off-target effect is induced through a pathway parallel to that for siRNA-mediated RNA interference
2008
RNAi microarray by reverse transfection of siRNA and shRNA for functional genomics
2008· 2 cited
Hox genes regulate the same character by different strategies in each segment
Mechanisms of Development·2008· 8 cited
Expansion of Substrate Specificity and Catalytic Mechanism of Azoreductase by X-ray Crystallography and Site-directed Mutagenesis
Journal of Biological Chemistry·2008· 69 citedOpen Access
Introduction of silencing‐inducing transgene against <i>Fgf19</i> does not affect expression of <i>Tbx5</i> and β3‐tubulin in the developing chicken retina
Development Growth & Differentiation·2008· 2 cited
Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect
Nucleic Acids Research·2008· 180 citedOpen Access
Evaluation of Published Rational siRNA Design Algorithms Using Firefly luciferase Gene as a Reporter
2008· 2 cited
New highly potent and specific E6 and E7 siRNAs for treatment of HPV16 positive cervical cancer
Cancer Gene Therapy·2007· 128 cited
Heparan Sulfate Regulates Self-renewal and Pluripotency of Embryonic Stem Cells
Journal of Biological Chemistry·2007· 109 citedOpen Access
17β-Estradiol at Physiological Concentrations Augments Ca2+-Activated K+ Currents via Estrogen Receptor β in the Gonadotropin-Releasing Hormone Neuronal Cell Line GT1-7
Endocrinology·2007· 45 citedOpen Access
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Frequent Co-authors

Kumiko Ui‐Tei(13), Shuhei Zenno(12), Tetsuya Kojima(8), S Inouye(8), Shunji Yuki(7), Masaru Tanokura(7), Ryu Ueda(4), Yuki Naito(4), Yasufumi Emori(3), Wataru Kugimiya(3), Shoko Nishihara(3), Hiroshi Sasaki(3), Makoto Sato(3), Shin‐ichi Higashijima(2), Tatsuo Michiue(2), Tadayoshi Shiba(2), François Leulier(2), Bruno Lemaître(2), Kenji Nishi(2), Kenji Yamato(2)