J. Scott Sawyer

Eli Lilly (United States) — United States

Chemistry · Physical Sciences

27h-index3.3kcitations62works0.02yr avg
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Research Topics

Chemical Synthesis and Reactions(11), Asthma and respiratory diseases(8), TGF-β signaling in diseases(8), Chemical Synthesis and Analysis(6), Asymmetric Synthesis and Catalysis(5)

Publications62 total

Preclinical assessment of galunisertib (LY2157299 monohydrate), a first-in-class transforming growth factor-β receptor type I inhibitor
Oncotarget·2017· 168 citedOpen Access
High-throughput ectopic expression screen for tamoxifen resistance identifies an atypical kinase that blocks autophagy
Proceedings of the National Academy of Sciences·2011· 107 citedOpen Access
Kinase requirements in human cells: V. Synthetic lethal interactions between p53 and the protein kinases SGK2 and PAK3
Proceedings of the National Academy of Sciences·2010· 90 citedOpen Access
Kinase requirements in human cells: IV. Differential kinase requirements in cervical and renal human tumor cell lines
Proceedings of the National Academy of Sciences·2008· 32 citedOpen Access
Kinase requirements in human cells: III. Altered kinase requirements in<i>VHL</i>−/− cancer cells detected in a pilot synthetic lethal screen
Proceedings of the National Academy of Sciences·2008· 140 citedOpen Access
Kinase requirements in human cells: I. Comparing kinase requirements across various cell types
Proceedings of the National Academy of Sciences·2008· 93 citedOpen Access
Optimization of a Dihydropyrrolopyrazole Series of Transforming Growth Factor-β Type I Receptor Kinase Domain Inhibitors: Discovery of an Orally Bioavailable Transforming Growth Factor-β Receptor Type I Inhibitor as Antitumor Agent
Journal of Medicinal Chemistry·2008· 66 citedOpen Access
ChemInform Abstract: A Concise Synthesis of Quinazolinone TGF‐β RI Inhibitor Through One‐Pot Three‐Component Suzuki—Miyaura/Etherification and Imidate—Amide Rearrangement Reactions.
ChemInform·2008
A concise synthesis of quinazolinone TGF-β RI inhibitor through one-pot three-component Suzuki–Miyaura/etherification and imidate–amide rearrangement reactions
Tetrahedron·2007· 17 cited
Kinetic Characterization of Novel Pyrazole TGF-β Receptor I Kinase Inhibitors and Their Blockade of the Epithelial−Mesenchymal Transition
Biochemistry·2005· 99 cited
Carbocyclic[<i>g</i>]indole Inhibitors of Human Nonpancreatic s-PLA<sub>2</sub>
Journal of Medicinal Chemistry·2005· 17 citedOpen Access
Development of TGF-β signalling inhibitors for cancer therapy
Nature Reviews Drug Discovery·2004· 543 cited
Synthesis and Activity of New Aryl‐ and Heteroaryl‐Substituted 5,6‐Dihydro‐4H‐pyrrolo[1,2‐b]pyrazole Inhibitors of the Transforming Growth Factor‐β Type I Receptor Kinase Domain.
ChemInform·2004· 2 cited
318 Dihydropyrrolopyrazoles as TGF-beta receptor kinase inhibitors for cancer therapy
European Journal of Cancer Supplements·2004· 1 cited
Synthesis and activity of new aryl- and heteroaryl-substituted 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole inhibitors of the transforming growth factor-β type I receptor kinase domain
Bioorganic & Medicinal Chemistry Letters·2004· 161 cited
Crystal Structure of TGF-beta receptor I kinase with ATP site inhibitor
2003
Synthesis and Activity of New Aryl- and Heteroaryl-Substituted Pyrazole Inhibitors of the Transforming Growth Factor-β Type I Receptor Kinase Domain
Journal of Medicinal Chemistry·2003· 237 citedOpen Access
COMBINING MEDICINAL CHEMISTRY WITH CHEMOGENOMIC AND COMPUTER-AIDED STRUCTURE-BASED DESIGN IN DEVELOPMENT OF NOVEL KINASE INHIBITORS
2003· 4 cited
ChemInform Abstract: Recent Advances in Diaryl Ether Synthesis
ChemInform·2000
Recent Advances in Diaryl Ether Synthesis
Tetrahedron·2000· 305 cited
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Frequent Co-authors

Larry L. Froelich(12), William T. Jackson(8), Ronald F. Baldwin(8), Jonathan M. Yingling(7), Douglas W. Beight(7), David K. Herron(7), William T. McMillen(7), Elisabeth A. Schmittling(7), Timothy L. Macdonald(6), Lei Yan(5), Ed Harlow(5), David L. Saussy(5), Michael J. Sofia(5), Stephen M. Spaethe(5), Philip Marder(5), Sandra L. Cockerham(5), Steven A. Silbaugh(5), Peter W. Stengel(5), Bryan D. Anderson(4), Theodore Goodson(4)